SCIENCE@home

The Role of the Vitreous Zonule in Preoperative Diagnosis of Zonular Laxity in Primary Angle-Closure Disease

Zhi-qiao Liang,Yijia Wang,Kun Lv,Yao Ma,Ye Lu,Kuankuan Wu,Huijuan Wu

Published 2025 in Clinical Ophthalmology

ABSTRACT

Purpose This study aimed to evaluate the diagnostic value of the number of visible vitreous zonule (VZ) quadrants in predicting zonular laxity in patients with primary angle-closure disease (PACD). Patients and Methods This prospective cohort study collected data between the period of November 2021 and February 2024. PACD patients were enrolled, with one eye selected randomly for analysis. The main outcome was the association between the presence/number of quadrants with visible VZ and the presence of zonular laxity. The diagnostic capability of the number of quadrants with VZ in determining zonular laxity was evaluated. Results A total of 50 patients were enrolled in the study. Compared with the VZ group, the no VZ group was more likely to manifest zonula laxity (14 of 14 [100%] vs 19 of 36 [53%], P = 0.002). The zonular laxity group had fewer quadrants with visible VZ (1.18 ± 0.22 vs 2.93 ± 0.22, P < 0.001) than the normal group. The number of quadrants for zonular laxity detection achieved an area under the curve of 0.855 (P < 0.001). The highest Youden Index was observed when the number of quadrants was less than 3, indicating superior diagnostic capability for zonular laxity, with a sensitivity of 84.9% and specificity of 70.6%. The highest sensitivity (93.9%) was achieved when the number of quadrants was less than 4. Conclusion The study found a link between VZ lack and zonular laxity in PACD, enhancing diagnosis with fewer VZ quadrants, and highlighted VZ’s diagnostic value.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-30 of 30 references · Page 1 of 1

CITED BY