The dual role of SLC7A11 in tumor drug resistance: mechanisms, challenges, and therapeutic potential.

Tumor drug resistance is a major factor in cancer treatment failure. SLC7A11 is characterized as a light-chain subunit antiporter of the Xc- system, responsible for exchanging extracellular cystine with intracellular glutamate. SLC7A11 has been shown to critically modulate tumor progression through regulation of intracellular cysteine homeostasis and redox balance, thereby governing ferroptosis and disulfidptosis. Ferroptosis and disulfidptosis are closely associated with tumor drug resistance, and SLC7A11 demonstrates a dual regulatory role in this process. This review summarized the structure and function of SLC7A11 and the mechanisms underlying tumor drug resistance. It then analyzed the potential regulatory effects of SLC7A11 on ferroptosis, disulfidptosis, and autophagy in the context of tumor chemotherapy, targeted therapy, immunotherapy resistance, and prognosis. Finally, this review delineated the therapeutic opportunities and translational challenges in targeting SLC7A11 to overcome tumor drug resistance, serving as a foundation for future mechanistic exploration and clinical development.

• Publication year

  2025

• Venue

  American Journal of Cancer Research

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.62347/gsbb1090PMID 41244134PMCID PMC12616170
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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