Knockdown of prolyl‐4‐hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA‐MB‐231 cells by affecting TGF‐β1 processing

No abstract is available for this paper.

• Publication year

  2013

• Venue

  International Journal of Cancer

• Publication date

  2013-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ijc.27982PMID 23225569
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ.

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• Disruption of Kv1.3 Channel Forward Vesicular Trafficking by Hypoxia in Human T Lymphocytes*

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  2011influential reference
• TGF-beta signaling, tumor microenvironment and tumor progression: the butterfly effect.

  2010cited by this paper
• Hypoxic conversion of SMAD7 function from an inhibitor into a promoter of cell invasion.

  2010cited by this paper
• Increased chemoresistance induced by inhibition of HIF‐prolyl‐hydroxylase domain enzymes

  2010cited by this paper
• Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasis

  2010cited by this paper
• Hypoxia-activated Smad3-specific Dephosphorylation by PP2A*

  2009cited by this paper
• In vivo functions of the prolyl‐4‐hydroxylase domain oxygen sensors: direct route to the treatment of anaemia and the protection of ischaemic tissues

  2009cited by this paper
• Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.

  2009cited by this paper
• Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression.

  2009cited by this paper
• The Biphasic Role of the Hypoxia-Inducible Factor Prolyl-4-Hydroxylase, PHD2, in Modulating Tumor-Forming Potential

  2008influential reference
• Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

  2008cited by this paper
• Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer.

  2006cited by this paper
• Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness.

  2006cited by this paper
• Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer

  2006cited by this paper
• Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.

  2006cited by this paper
• Induction of human endometrial cancer cell senescence through modulation of HIF‐1α activity by EGLN1

  2006cited by this paper
• Hypoxia-enhanced Expression of the Proprotein Convertase Furin Is Mediated by Hypoxia-inducible Factor-1

  2005cited by this paper
• Role of osteopontin in tumour progression

  2004cited by this paper
• Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor*

  2004cited by this paper
• Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.

  2003cited by this paper
• The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

  2003cited by this paper
• Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

  2003cited by this paper
• The hypoxia-inducible factor-1α is a negative factor for tumor therapy

  2003cited by this paper
• Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

  2003cited by this paper
• Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

  2003cited by this paper
• Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

  2002cited by this paper
• Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

  2002cited by this paper
• Furin at the cutting edge: From protein traffic to embryogenesis and disease

  2002cited by this paper
• Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

  2002cited by this paper
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  2001cited by this paper
• TGFbeta and BMP-2 activation of the OPN promoter: roles of smad- and hox-binding elements.

  2001cited by this paper
• Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

  2001cited by this paper
• Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme.

  2001cited by this paper
• The Role of Osteopontin in Breast Cancer: Clinical and Experimental Studies

  2001cited by this paper
• Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy.

  2001cited by this paper
• HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

  2001cited by this paper
• C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

  2001cited by this paper
• A Furin-like Convertase Mediates Propeptide Cleavage of BACE, the Alzheimer's β-Secretase*

  2000cited by this paper
• Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases.

  2000cited by this paper
• The role for transforming growth factor-beta (TGF-beta) in human cancer.

  1999cited by this paper
• Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis.

  1999cited by this paper
• Subcellular localization of (latent) transforming growth factor beta and the latent TGF-beta binding protein in rat hepatocytes and hepatic stellate cells.

  1998cited by this paper
• Subcellular localization of (latent) transforming growth factor β and the latent TGF‐β binding protein in rat hepatocytes and hepatic stellate cells

  1998cited by this paper
• BMP‐4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development

  1998cited by this paper
• Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.

  1998cited by this paper
• Heterotransplantation of primary and established human tumour cells in nude mice.

  1995cited by this paper
• Retention of the transforming growth factor-beta 1 precursor in the Golgi complex in a latent endoglycosidase H-sensitive form.

  1992cited by this paper
• Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide

  1988cited by this paper

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• Hypoxia-inducible factor in breast cancer: role and target for breast cancer treatment

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• Alpha-ketoglutarate-dependent enzymes in breast cancer and therapeutic implications.

  2023cites this paper
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• Evolving Strategies in the Treatment of Anaemia in Chronic Kidney Disease: The HIF-Prolyl Hydroxylase Inhibitors

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• Role of Hypoxia in the Control of the Cell Cycle

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• HIF-1 stabilization exerts anticancer effects in breast cancer cells in vitro and in vivo.

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