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Abnormal Alterations in EEG Microstates and Functional Networks in Anti-LGI1 Antibody Encephalitis

Lei Wang,Ping Jiang,Yingfan Wang,Dingfeng Sun,Ailiang Miao,Xiaoshan Wang

Published 2025 in Journal of Inflammation Research

ABSTRACT

Objective This study aimed to use electroencephalogram (EEG) microstate analysis to characterize transient topographic patterns and rapid brain network reorganization in anti-leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis (anti-LGI1-AE). Methods EEG data were collected from fifteen patients with anti-LGI1-AE and eighteen age- and sex-matched controls. K-means clustering was used to extract microstate sequences, and temporal parameters were compared between groups. For microstates showing significant differences, weighted phase lag index matrices were computed across frequency bands, and network-based statistics were applied to identify functional connectivity differences. Results The topographic pattern of Microstate A differed significantly between the anti-LGI1-AE group and the control group (p = 0.002). Patients exhibited a significantly higher occurrence of Microstates B and C (p = 0.015 and p = 0.001, respectively). Additionally, the mean global field power of Microstate C was reduced in the patient group (p = 0.007). The transition probability from Microstate A to B was increased in patients (p = 0.013), though this difference did not remain significant after false discovery rate (FDR) correction (pFDR = 0.161). EEG functional network analysis based on microstates with significant differences revealed that, during Microstate B, patients showed a widespread increase in whole-brain functional connectivity in the beta frequency band (all p < 0.001). During Microstate C, enhanced delta-band connectivity was observed with the left occipital region serving as a core hub (p = 0.002). Beta-band connectivity was also increased between the left posterior temporal region, midline structures, and left parietal regions (p = 0.037). Conclusion Widespread alterations in functional brain networks are present in anti-LGI1-AE. Changes in microstate temporal parameters and enhanced functional connectivity may reflect compensatory regulatory mechanisms or pathological hyperactivation, revealing functional brain changes that go beyond overt structural damage.

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