Electrochemical sensing of neuropeptide Y using peptide-based detection molecule

Neuropeptide Y (NPY) is a key biomolecule involved in the regulation of stress and several neurological disorders. Existing sensors for NPY typically rely on antibodies or aptamers as biorecognition elements. In this work, we report the detection of NPY via electrochemical impedance spectroscopy (EIS) using a short, synthetic peptide-based recognition molecules, P1N2. Our results demonstrate that P1N2 recognition yields a linear impedance response over a picomolar range of NPY, with excellent selectivity against control peptide, peptide YY (PYY). Our study suggests that peptide-based EIS sensors can provide a competitive alternative to antibody- and aptamer-based platforms for neuropeptide detection.

• Publication year

  2025

• Venue

  Biosensors

• Publication date

  2025-08-02

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1109/BioSensors65002.2025.11239287
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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