Haplodeficiency of Klotho Gene Causes Arterial Stiffening via Upregulation of Scleraxis Expression and Induction of Autophagy

No abstract is available for this paper.

• Publication year

  2015

• Venue

  HYPERTENSION

• Publication date

  2015-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/HYPERTENSIONAHA.115.06033PMID 26324504PMCID PMC4600046
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular basis of Klotho: from gene to function in aging.

  2015cited by this paper
• Autophagy and mitophagy in diabetic cardiomyopathy.

  2015cited by this paper
• Aging, arterial stiffness, and hypertension.

  2015cited by this paper
• In Vivo Pancreatic β-Cell–Specific Expression of Antiaging Gene Klotho: A Novel Approach for Preserving β-Cells in Type 2 Diabetes

  2014cited by this paper
• Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise

  2014cited by this paper
• Arterial stiffness: a novel cardiovascular risk factor in kidney disease patients.

  2014cited by this paper
• Role of Renin-Angiotensin-Aldosterone System in Metabolic Syndrome and Obesity-related Hypertension.

  2014cited by this paper
• Antiaging gene Klotho regulates endothelin-1 levels and endothelin receptor subtype B expression in kidneys of spontaneously hypertensive rats

  2014cited by this paper
• Arterial Stiffness as a Risk Factor for Coronary Artery Disease

  2014cited by this paper
• AAV Delivery of Tumor Necrosis Factor-&agr; Short Hairpin RNA Attenuates Cold-Induced Pulmonary Hypertension and Pulmonary Arterial Remodeling

  2014cited by this paper
• Ginsenoside Rg1 protects mouse podocytes from aldosterone-induced injury in vitro

  2014cited by this paper
• Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women.

  2014cited by this paper
• Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity

  2013cited by this paper
• A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease

  2013cited by this paper
• The Role of Tissue Renin-Angiotensin-Aldosterone System in the Development of Endothelial Dysfunction and Arterial Stiffness

  2013cited by this paper
• Genetic deficiency of anti-aging gene klotho exacerbates early nephropathy in STZ-induced diabetes in male mice.

  2013cited by this paper
• Interferon-γ ablation exacerbates myocardial hypertrophy in diastolic heart failure.

  2012cited by this paper
• Aortic stiffness, blood pressure progression, and incident hypertension.

  2012cited by this paper
• Elastin in Large Artery Stiffness and Hypertension

  2012cited by this paper
• AAV-Based RNAi Silencing of NADPH Oxidase gp91 phox Attenuates Cold-Induced Cardiovascular Dysfunction

  2012cited by this paper
• Synergistic roles of scleraxis and Smads in the regulation of collagen 1α2 gene expression.

  2012cited by this paper
• Arterial stiffness, vascular aging, and intracranial large artery disease.

  2011cited by this paper
• Aortic stiffness: current understanding and future directions.

  2011cited by this paper
• A systems biology viewpoint on autophagy in health and disease

  2010cited by this paper
• Hyperaldosteronism in Klotho-deficient mice.

  2010cited by this paper
• The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis.

  2009cited by this paper
• Klotho and aging.

  2009cited by this paper
• Aldosterone induces arterial stiffness in absence of oxidative stress and endothelial dysfunction

  2009cited by this paper
• Current understanding of klotho.

  2009cited by this paper
• Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging.

  2008cited by this paper
• Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons

  2007cited by this paper
• The influence of serum aldosterone and the aldosterone–renin ratio on pulse wave velocity in hypertensive patients

  2007cited by this paper
• Scleraxis and NFATc Regulate the Expression of the Pro-α1(I) Collagen Gene in Tendon Fibroblasts*

  2007cited by this paper
• Arterial stiffness is an independent risk factor for cognitive impairment in the elderly: a pilot study

  2005cited by this paper
• Suppression of Aging in Mice by the Hormone Klotho

  2005cited by this paper
• Klotho is a serum factor related to human aging.

  2004cited by this paper
• A somitic compartment of tendon progenitors.

  2003cited by this paper
• Systolic blood pressure, pulse pressure and arterial stiffness as cardiovascular risk factors

  2001cited by this paper
• Association Between Arterial Stiffness and Atherosclerosis: The Rotterdam Study

  2001cited by this paper
• Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments.

  2001cited by this paper
• Arterial remodeling in atherosclerosis, restenosis and after alteration of blood flow: potential mechanisms and clinical implications.

  2000cited by this paper
• Arterial stiffness and the development of hypertension

  2000cited by this paper
• Arterial Remodeling: Mechanisms and Clinical Implications

  2000cited by this paper
• Arterial stiffness and the development of hypertension. The ARIC study.

  1999cited by this paper
• Mutation of the mouse klotho gene leads to a syndrome resembling ageing

  1997influential reference
• Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis.

  1995cited by this paper

• Fibulin 2 Deficiency Drives Epigenetic Hypertension.

  2025cites this paper
• From Cells to Plaques: The Molecular Pathways of Coronary Artery Calcification and Disease

  2024cites this paper
• Implications of endoplasmic reticulum stress and autophagy in aging and cardiovascular diseases

  2024cites this paper
• KDM6A Demethylase Regulates Renal Sodium Excretion and Blood Pressure

  2024cites this paper
• Single Cell Mapping of Large and Small Arteries during Hypertensive Aging.

  2023cites this paper
• Mitochondrial Homeostasis in VSMCs as a Central Hub in Vascular Remodeling

  2023cites this paper
• Reduced Levels of the Antiaging Hormone Klotho are Associated With Increased Aortic Stiffness in Diabetic Kidney Disease

  2023cites this paper
• Comparing Western and traditional Chinese medicine for male sexual dysfunction: can Klotho represent a silk road?

  2023cites this paper
• Cardioprotective and Antifibrotic Effects of Low-Dose Renin–Angiotensin–Aldosterone System Inhibitors in Type 1 Diabetic Rat Model

  2023cites this paper
• L-type calcium ion channel-mediated activation of autophagy in vascular smooth muscle cells via thonningianin A (TA) alleviates vascular calcification in type 2 diabetes mellitus.

  2023cites this paper
• Effect of eplerenone on cognitive impairment in spontaneously hypertensive rats.

  2022cites this paper
• Klotho Protein Decreases MMP-Mediated Degradation of Contractile Proteins during Ischaemia/Reperfusion Injury to the Cardiomyocytes

  2022cites this paper
• VEGFR2 insufficiency enhances phosphotoxicity and undermines Klotho's protection against peritubular capillary rarefaction and kidney fibrosis.

  2022cites this paper
• Klotho Ameliorates Vascular Calcification via Promoting Autophagy

  2022cites this paper
• Aging impairs arterial compliance via Klotho-mediated downregulation of B-cell population and IgG levels

  2022cites this paper
• Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

  2022cites this paper
• Klotho Modulates Pro-Fibrotic Activities in Human Atrial Fibroblasts through Inhibition of Phospholipase C Signaling and Suppression of Store-Operated Calcium Entry

  2022cites this paper
• Kidney-Specific Klotho Gene Deletion Causes Aortic Aneurysm via Hyperphosphatemia

  2021cites this paper
• Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux

  2021cites this paper
• Mechanism of cell death of endothelial cells regulated by mechanical forces.

  2021cites this paper
• Toll-like receptor 4 mutation protects the kidney from Ang-II-induced hypertensive injury.

  2021cites this paper
• Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers

  2021cites this paper
• The intersection of Mineralocorticoid Receptor (MR) activation and the FGF23 - Klotho cascade. A Duopoly that promotes renal and cardiovascular injury.

  2021cites this paper
• Estrogen inhibits renal Na-Pi Co-transporters and improves klotho deficiency-induced acute heart failure

  2021cites this paper
• Klotho as Potential Autophagy Regulator and Therapeutic Target

  2021cites this paper
• Soluble Klotho and Incident Hypertension

  2021cites this paper
• Multiple functions of autophagy in vascular calcification

  2021cites this paper
• Klotho deficiency‐induced arterial calcification involves osteoblastic transition of VSMCs and activation of BMP signaling

  2021cites this paper
• Role of Klotho in the Development of Essential Hypertension.

  2021cites this paper
• Uremic Toxins and Vascular Dysfunction

  2020cites this paper
• Autophagy as an emerging therapeutic target for age-related vascular pathologies

  2020cites this paper
• Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells

  2020cites this paper
• New progress on the study of aortic stiffness in age-related hypertension.

  2020cites this paper
• Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension

  2020cites this paper
• Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency.

  2020cites this paper
• Pro- and anti-inflammatory factors, vascular stiffness and outcomes in chronic hemodialysis patients.

  2020cites this paper
• In vivo AAV delivery of glutathione reductase gene attenuates anti-aging gene klotho deficiency-induced kidney damage

  2020cites this paper
• Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway.

  2020cites this paper
• Klotho, Hypertension and Arterial Stiffness: A Review

  2019cites this paper
• Autophagy plays a critical role in Klotho gene deficiency-induced arterial stiffening and hypertension

  2019cites this paper
• Klotho deficiency induces arteriolar hyalinosis in a trade-off with vascular calcification.

  2019cites this paper
• Beneficial Effect of Bariatric Surgery on Abnormal MMP-9 and AMPK Activities: Potential Markers of Obesity-Related CV Risk

  2019cites this paper
• The role of dipeptidylpeptidase-4 inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin

  2018cites this paper
• Knockdown of transglutaminase-2 prevents early age-induced vascular changes in mice1.

  2018cites this paper
• Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease

  2018cites this paper
• Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension.

  2018cites this paper
• Klotho modulates ER-mediated signaling crosstalk between prosurvival autophagy and apoptotic cell death during LPS challenge

  2018cites this paper
• Metabolic Stress, Autophagy, and Cardiovascular Aging: from Pathophysiology to Therapeutics.

  2018cites this paper
• Aorto-Coronary Haemodynamics: Studies in Cardiovascular Magnetic Resonance

  2018cites this paper
• The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study

  2018cites this paper
• Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1

  2018cites this paper
• Activation of DNA demethylases attenuates aging‐associated arterial stiffening and hypertension

  2018cites this paper
• Regulation of cardiac fibroblast MMP2 gene expression by scleraxis.

  2018cites this paper
• A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension

  2017cites this paper
• Mechanisms and Subclinical Consequences of Aortic Stiffness.

  2017cites this paper
• Role of Platelet-Derived Transforming Growth Factor-β1 and Reactive Oxygen Species in Radiation-Induced Organ Fibrosis

  2017cites this paper
• Role of second-hand smoke (SHS)-induced proteostasis/autophagy impairment in pediatric lung diseases

  2017cites this paper
• University of Groningen Effects of Klotho on fibrosis and cancer

  2017cites this paper
• Vascular ageing: Underlying mechanisms and clinical implications

  2017influential citation
• The role of the anti-ageing protein Klotho in vascular physiology and pathophysiology.

  2017influential citation
• Synergistic Research Between the Center of Arrhythmia Research and the Michigan Biology of Cardiovascular Aging at the University of Michigan.

  2017cites this paper
• Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies

  2017cites this paper
• AAV Delivery of Endothelin-1 shRNA Attenuates Cold-Induced Hypertension

  2017cites this paper
• Regulation of S-formylglutathione hydrolase by the anti-aging gene klotho

  2017cites this paper
• Dietary potassium regulates vascular calcification and arterial stiffness.

  2017cites this paper
• Effects of substrate stiffness on the tenoinduction of human mesenchymal stem cells.

  2017cites this paper
• Does Aldosterone Play a Significant Role for Regulation of Vascular Tone?

  2016cites this paper
• Monocrotaline-Induced Pulmonary Hypertension Involves Downregulation of Antiaging Protein Klotho and eNOS Activity

  2016cites this paper
• Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study

  2016cites this paper
• Accelerated Vascular Aging as a Paradigm for Hypertensive Vascular Disease: Prevention and Therapy.

  2016cites this paper
• Activation of SIRT1 Attenuates Klotho Deficiency–Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity

  2016cites this paper
• Deficiency in the anti‐aging gene Klotho promotes aortic valve fibrosis through AMPKα‐mediated activation of RUNX2

  2016influential citation