Fluorinated Para‐Quinone Monoacetal: Versatile Reactivity for Constructing Functionalized Scaffolds

ABSTRACT A concise synthetic route to the difluorinated para‐quinone monoacetals (p‐QMAs) and their reactivity is described. Featuring a cross‐conjugated dienone core and an acetal unit, these compounds undergo diverse nucleophilic additions at the enone moiety and cycloadditions at the C═C bond. Such distinctive reactivity renders the β,β′‐difluoro p‐QMA a versatile building block for the rapid assembly of complex molecular architectures, highlighting its promise in natural product synthesis and material sciences.

• Publication year

  2025

• Venue

  Chemistry - An Asian Journal

• Publication date

  2025-11-30

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1002/asia.202500921PMID 41320648PMCID 12711386
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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