Adipose tissue metabolomics identifies disease stage and tumour invasiveness of rectal cancer

Lidia Cornejo Fernández,Laura Gallardo-Nuell,Anna Pigem Rodeja,Irma Ramos-Oliver,Olga Delisau-Puig,Eloi Maldonado-Marcos,J. Rodríguez-Hermosa,R. F. Coll,Antonio Codina-Cazador,J. Mayneris‐Perxachs,J. Fernández-Real,Pere Planellas Giné

Published 2025 in European Journal of Clinical Investigation

ABSTRACT

Adipose tissue has emerged as a prognostic factor in rectal cancer (RC), yet its metabolic role in tumour progression remains poorly understood. This study aims to characterise the metabolic profiles of subcutaneous (SAT) and visceral adipose tissue (VAT) in early and advanced tumours to investigate metabolic alterations that may influence tumour progression. Understanding these alterations could provide insights into mechanisms of rectal cancer and identify therapeutic targets.

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