Development of a migration model for additives in desiccants and deoxidisers in food packaging using rice flour as food stimulant

Abstract Desiccants and deoxidisers in food packaging come into direct contact with food, potentially leading to the migration of harmful substances. However, certain desiccants undergo chemical reactions that are detrimental to detection when exposed to certain liquid simulants. In response, this study established a migration evaluation model using a solid simulant (rice flour) and a quantitative method based on liquid chromatography-tandem mass spectrometry (LC-TQ/MS). Using the new model, we tested 17 antioxidants and UV absorbers that may migrate from commonly used desiccants and deoxidisers. The results showed that four substances migrated and were detected, including 2,4-di-t-butylphenol, 2,6-di-t-butyl-p-cresol (antioxidant 264), octadecyl 3-(3,5-di-t-butyl-4-hydroxyphenyl) propionate (antioxidant 1076), and tris(2,4-di-t-butylphenyl) phosphite (antioxidant 168). The detected levels were all below safety limits and did not pose a food safety risk. However, the level of antioxidant 264 was close to the migration limit set by the EU, warranting further investigation and monitoring. These findings verify the feasibility of the solid-state migration model and draw attention to the potential safety risks of desiccants and deoxidisers in food. They provide a robust scientific basis and practical guidance for future food safety regulation, standard-setting, and industrial upgrading.

• Publication year

  2025

• Venue

  Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment

• Publication date

  2025-12-15

• Fields of study

  Agricultural and Food Sciences, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1080/19440049.2025.2591807PMID 41397221
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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