Biocompatible thermal shape-memory poly(lactide-co-trimethylene carbonate) elastomers for cell culture scaffold application.

Biocompatible shape-memory polymers are promising next-generation tissue engineering biomaterials that possess low toxicity, tunable mechanical strength, and programmable movement and actuation properties. To develop low cost, biocompatible and controllable shape-memory polymers, in this work, we prepared Poly(lactide-co-trimethylene carbonate) copolymers (PDTs) by incorporating flexible trimethylene carbonate (TMC) segments into the rigid poly(DL-lactide) (PDLLA) backbone via ring-opening copolymerization. The polymerization conditions were optimized through a systematic orthogonal experimental design. Compared with brittle PDLLA (initial elongation at break: ∼7%), the introduction of TMCs resulted in a significant improvement in the flexibility and ductility (elongation at break for PDT: 27.6-1288%). The thermal shape-memory/recovery rate of PDTs after cyclic deformation is more than 95%, the adjustable thermomechanical properties (Tg: 41.54-10.14 °C) enable their programmable thermal shape-memory function. Moreover, the introduction of TMCs could alleviate local acid degradation of PDLLA, improve the hydrophilicity (water contact angle reduced from 97.75° to 62.25°), and maintain excellent cytocompatibility (meet the medical grade standard). The results showed that PDT copolymers possess tunable elasticity, acid degradation resistance, and enhanced bioactivity, making them promising biocompatible thermal shape-memory elastomers for cell culture scaffold application towards tissue engineering.

• Publication year

  2026

• Venue

  Journal of materials chemistry. B

• Publication date

  2026-01-09

• Fields of study

  Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.1039/d5tb02473kPMID 41510700
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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