Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis

The type I intermediate filament keratin 15 (K15) exhibits preferential expression in a subset of skin keratinocytes with stem-like properties. We report that K15 promotes the progenitor state by counteracting the ability of the related K14 to negatively regulate YAP1, a terminal effector of Hippo signaling.

• Publication year

  2026

• Venue

  Journal of Cell Biology

• Publication date

  2026-01-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.202503046PMID 41511042PMCID 12784932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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