Diagnostic efficacy of blood biomarkers for differentiating early-stage pancreatic cancer from chronic pancreatitis: A systematic review and network meta-analysis

Highlights • Carbohydrate antigen 19–9 (CA199) demonstrated only moderate diagnostic discrimination between pancreatic cancer (PC) and chronic pancreatitis (CP), with reduced efficacy in early-stage PC.• Tumor polypeptide antigen (TPA), microRNAs, extracellular vesicle long RNAs (exLRs), metabolites panel, and carcinoembryonic antigen (CEA) showed unique strengths in their diagnostic ability.• The application of multi-marker panels, particularly those that incorporate miRNAs and exLRs, for early detection of PC in CP holds significant clinical value for improving patient management.

• Publication year

  2026

• Venue

  Translational Oncology

• Publication date

  2026-01-16

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.tranon.2026.102674PMID 41547146PMCID 12834843
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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