Exploring the Anticonvulsant and Neuropreventive Effects of Ganoderma lucidum Extract in the Pentylenetetrazole-Kindling Model: Analysis of Cognitive Comorbidities Associated with Epilepsy

No abstract is available for this paper.

• Publication year

  2026

• Venue

  Neurochemical Research

• Publication date

  2026-01-20

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1007/s11064-026-04663-4PMID 41557102
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evaluation of the Potential Anticonvulsant and Neuroprotective Effects of Ganoderma Lucidum Extract in an Animal Model of Pentylenetetrazol-Induced Seizures

  2025cited by this paper
• Polysaccharides from Ganoderma lucidum attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation

  2025cited by this paper
• Ganoderma atrum polysaccharides attenuates cadmium mediated hepatorenal dysfunction, oxidative stress, inflammation response, and metabolic disorders in mice.

  2025cited by this paper
• Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an update

  2025cited by this paper
• Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection

  2024cited by this paper
• Efficient water-soluble copper(II) complexes with SOD/CO-like activities and the relationship between their structure and activity

  2024cited by this paper
• "Sigma-1 receptor modulation by clemastine highlights its repurposing as neuroprotective agent against seizures and cognitive deficits in PTZ-kindled rats".

  2024cited by this paper
• Neuroprotective prospectives of triterpenoids

  2024cited by this paper
• Chronic stress intensify PTZ-induced seizures by triggering neuroinflammation and oxidative stress.

  2024cited by this paper
• Chemodiversity, pharmacological activity, and biosynthesis of specialized metabolites from medicinal model fungi Ganoderma lucidum

  2024cited by this paper
• Kindling Models of Epileptogenesis for Developing Disease‐Modifying Drugs for Epilepsy

  2024cited by this paper
• Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers.

  2023cited by this paper
• Natural Bio-Compounds from Ganoderma lucidum and Their Beneficial Biological Actions for Anticancer Application: A Review

  2023cited by this paper
• Male rats are more vulnerable to pentylenetetrazole-kindling model but females have more spatial memory-related deficits.

  2022cited by this paper
• Investigation into Antiepileptic Effect of Ganoderic Acid A and Its Mechanism in Seizure Rats Induced by Pentylenetetrazole

  2022cited by this paper
• Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids

  2022cited by this paper
• Mycopharmaceuticals and Nutraceuticals: Promising Agents to Improve Human Well-Being and Life Quality

  2021cited by this paper
• Neuroproteomics in Epilepsy: What Do We Know so Far?

  2021cited by this paper
• Reviving Mitochondrial Bioenergetics: a relevant approach in epilepsy.

  2021cited by this paper
• Antidepressant-like effect of Ganoderma lucidum spore polysaccharide-peptide mediated by upregulation of prefrontal cortex brain-derived neurotrophic factor

  2021cited by this paper
• Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies

  2021cited by this paper
• Effects of spore powder of ganoderma lucidum on CaSR and apoptosis-related proteins in hippocampus tissue of epilepsy following dementia

  2020cited by this paper
• Prophylactic effects of sporoderm-removed Ganoderma lucidum spores in a rat model of streptozotocin-induced sporadic Alzheimer's disease.

  2020cited by this paper
• Effects of Spore Powder of Ganoderma Lucidum on CaSR and apoptosis-related proteins in hippocampus tissue of epilepsy following dementia: a protocol of systematic review

  2020influential reference
• Ganoderma lucidum Triterpenoids (GLTs) Reduce Neuronal Apoptosis via Inhibition of ROCK Signal Pathway in APP/PS1 Transgenic Alzheimer's Disease Mice

  2020cited by this paper
• Protective effects of curcumin and Ganoderma lucidum on hippocampal damage caused by the organophosphate insecticide chlorpyrifos in the developing rat brain: Stereological, histopathological and immunohistochemical study.

  2020cited by this paper
• Excitotoxicity, neuroinflammation and oxidant stress as molecular bases of epileptogenesis and epilepsy-derived neurodegeneration: The role of vitamin E.

  2019cited by this paper
• Anti-Cancer Effects of a Neutral Triterpene Fraction from Ganoderma lucidum and its Active Constituents on SW620 Human Colorectal Cancer Cells.

  2019cited by this paper
• Health Benefits of Ganoderma lucidum as a Medicinal Mushroom

  2019cited by this paper
• Effect of Ganoderma lucidum polysaccharides on oxidative damage in liver of STZ-diabetic rats

  2018cited by this paper
• Evaluation of aphrodisiac activity of ethanol extract of Ganoderma lucidum in male Wistar rats

  2018cited by this paper
• Role of inflammation in epilepsy and neurobehavioral comorbidities: Implication for therapy.

  2018cited by this paper
• Neuroprotective Effect of Coumarin Nasal Formulation: Kindling Model Assessment of Epilepsy

  2018cited by this paper
• Ganoderic acid A potentiates the antioxidant effect and protection of mitochondrial membranes and reduces the apoptosis rate in primary hippocampal neurons in magnesium free medium.

  2018cited by this paper
• Ganoderma lucidum: Persuasive biologically active constituents and their health endorsement.

  2018cited by this paper
• Ganoderma Lucidum Protects Rat Brain Tissue Against Trauma-Induced Oxidative Stress

  2017cited by this paper
• Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling Epilepsy-Induced Hippocampal Endoplasmic Reticulum Stress and Oxidative Damage

  2017cited by this paper
• Anti-amnesic effects of Ganoderma species: A possible cholinergic and antioxidant mechanism.

  2017cited by this paper
• Deletion of Type 3 Adenylyl Cyclase Perturbs the Postnatal Maturation of Olfactory Sensory Neurons and Olfactory Cilium Ultrastructure in Mice

  2017cited by this paper
• Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis

  2017cited by this paper
• Effectiveness of ketogenic diet in pentylenetetrazol-induced and kindling rats as well as its potential mechanisms.

  2016cited by this paper
• Epileptogenic effects of G protein-coupled estrogen receptor 1 in the rat pentylenetetrazole kindling model of epilepsy

  2016cited by this paper
• Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline.

  2016cited by this paper
• Alzheimer's Disease: Targeting the Cholinergic System

  2016cited by this paper
• Anti-Amnesic Effect of Fermented Ganoderma lucidum Water Extracts by Lactic Acid Bacteria on Scopolamine-Induced Memory Impairment in Rats

  2015cited by this paper
• Early metabolic responses to lithium/pilocarpine‐induced status epilepticus in rat brain

  2015cited by this paper
• Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D.

  2014cited by this paper
• Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

  2014cited by this paper
• Anti-Epileptic Effect of Ganoderma Lucidum Polysaccharides by Inhibition of Intracellular Calcium Accumulation and Stimulation of Expression of CaMKII α in Epileptic Hippocampal Neurons

  2014cited by this paper
• Acetylcholinesterase Inhibition and in Vitro and in Vivo Antioxidant Activities of Ganoderma lucidum Grown on Germinated Brown Rice

  2013cited by this paper
• Contribution of CA3 and CA1 pyramidal neurons to the tonic α7 nAChR-dependent glutamatergic input to CA1 pyramidal neurons.

  2013cited by this paper
• Epilepsy and brain inflammation.

  2013cited by this paper
• Neuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus.

  2012cited by this paper
• Matrix Metalloproteinase-9 Contributes to Kindled Seizure Development in Pentylenetetrazole-Treated Mice by Converting Pro-BDNF to Mature BDNF in the Hippocampus

  2011cited by this paper
• Role of oxidative stress in epileptic seizures.

  2011cited by this paper
• Natural Products in Epilepsy—the Present Situation and Perspectives for the Future

  2010cited by this paper
• Effects of ganoderma lucidum spores powder on expression of NCAM‐1 and NCAM‐L1 in hippocampus of rats with epilepsy

  2010cited by this paper
• Derivatives of benzimidazole pharmacophore: synthesis, anticonvulsant, antidiabetic and DNA cleavage studies.

  2010cited by this paper
• The differential effects of protein synthesis inhibition on the expression and reconsolidation of pentylenetetrazole kindled seizures.

  2010cited by this paper
• On the participation of hippocampal PKC in acquisition, consolidation and reconsolidation of spatial memory.

  2007cited by this paper
• Oxidative stress: A bridge between Down's syndrome and Alzheimer's disease

  2007cited by this paper
• Epilepsy Care in the World: Results of an ILAE/IBE/WHO Global Campaign Against Epilepsy Survey

  2006cited by this paper
• Molecular Signaling Mechanisms Underlying Epileptogenesis

  2006cited by this paper
• Morris water maze: procedures for assessing spatial and related forms of learning and memory

  2006cited by this paper
• A new frontier in epilepsy: novel antiepileptogenic drugs.

  2006cited by this paper
• Ganoderma lucidum inhibits inducible nitric oxide synthase expression in macrophages

  2005cited by this paper
• Pilocarpine-induced status epilepticus in rats: lipid peroxidation level, nitrite formation, GABAergic and glutamatergic receptor alterations in the hippocampus, striatum and frontal cortex.

  2004cited by this paper
• The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory.

  2004cited by this paper
• Publisher's Note

  2003cited by this paper
• Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum

  2001cited by this paper
• Pentylenetetrazole kindling impairs long-term memory in rats.

  1995influential reference
• Catalase in vitro.

  1984cited by this paper
• Nitrate biosynthesis in man.

  1981cited by this paper
• Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.

  1971cited by this paper
• THE NISSL SUBSTANCE OF LIVING AND FIXED SPINAL GANGLION CELLS

  1957cited by this paper
• THE NISSL SUBSTANCE OF LIVING AND FIXED SPINAL GANGLION CELLS

  1956cited by this paper
• Frontiers in Aging Neuroscience Aging Neuroscience Review Article

  year unknowninfluential reference
• Effects of Ganoderma Lucidum Extract on Morphine-Induced Addiction and Memory Impairment in Mice

  year unknowncited by this paper
• Nitrate biosynthesis in man ( metabolism / stable isotopes / carcinogenesis )

  year unknowncited by this paper
• Frontiers in Aging Neuroscience Aging Neuroscience Review Article

  year unknowncited by this paper

• No citing papers are available for this paper.