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Probiotic and Dietary Supplements Intervention in Age-Related Neurodegenerative Disorders.

Carolina Beatrice D’Anniballe De Salles,S. K. Prajapati,Dhananjay Yadav,Joell Rennar,Andrea Marcano-Rodriguez,Hariom Yadav,Shalini Jain

Published 2026 in Microorganisms

ABSTRACT

Age-related neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and mild cognitive impairment, represent a growing global health challenge. The present medicines offer only symptomatic alleviation with poor disease-modifying efficacy. Increasing data suggests that the gut-brain axis and dietary health are measurable contributions to cognitive impairment as we age. This review first focused on the mechanistic link between gut dysbiosis and neurodegeneration. Furthermore, the review discusses preclinical and clinical research that show how probiotics and dietary supplements improve brain function in the elderly using supplemental therapy methods. It also indicates that randomized clinical studies and meta-analyses suggest that probiotics and particular nutritional supplements provide modest but consistent cognitive advantages, which are most noticeable when patients receive therapy at the initial stage of their disease development. These advantages might originate from the combined impact of gut microbiota, immunological signaling, and neuroprotective pathways, rather than specific targeted approaches. Thus, the current review highlights the reports, suggesting that probiotics and dietary supplements might be effective and safe therapies for age-related neurodegeneration.

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