Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila

Raiko Stephan,Christina Gohl,Astrid Fleige,C. Klämbt,S. Bogdan

Published 2011 in Molecular Biology of the Cell

ABSTRACT

The Abelson interactor (Abi) has a conserved role in Arp2/3-dependent actin polymerization, regulating WASP and WAVE. In this study, the function of Abi was analyzed in the context of the developing fly visual system, and the steps in the molecular regulation of WAVE activity by its regulatory complex in vivo were identified.

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