UV filter decomposition. A study of reactions of 4-(2-aminophenyl)-4-oxocrotonic acid with amino acids and antioxidants present in the human lens.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Experimental Eye Research

• Publication date

  2007-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.EXER.2007.04.008PMID 17574242
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Glucoside of 3‐Hydroxykynurenine and other Fluorescent Compounds in the Human Lens

  2008cited by this paper
• 3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis.

  2006cited by this paper
• Photochemical and thermal reactivity of kynurenine.

  2006cited by this paper
• Identification of the new UV filter compound cysteine‐l‐3‐hydroxykynurenine O‐β‐d‐glucoside in human lenses

  2006cited by this paper
• Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract.

  2006cited by this paper
• Age-related nuclear cataract-oxidation is the key.

  2005cited by this paper
• Photochemistry of kynurenine, a tryptophan metabolite: properties of the triplet state.

  2005cited by this paper
• Deamination of 3-hydroxykynurenine in bovine lenses: a possible mechanism of cataract formation in general

  2004cited by this paper
• Protein-bound kynurenine is a photosensitizer of oxidative damage.

  2004cited by this paper
• Human cataract: the mechanisms responsible; light and butterfly eyes.

  2003cited by this paper
• Glutathione and NADH, but not ascorbate, protect lens proteins from modification by UV filters.

  2002cited by this paper
• UV filter instability: consequences for the human lens.

  2002cited by this paper
• Identifying sites of attachment of UV filters to proteins in older human lenses.

  2002cited by this paper
• Novel Protein Modification by Kynurenine in Human Lenses*

  2002cited by this paper
• Major changes in human ocular UV protection with age.

  2001cited by this paper
• Kynurenine Binds to the Peptide Binding Region of the Chaperone αB-Crystallin

  2001cited by this paper
• Kynurenine binds to the peptide binding region of the chaperone alphaB-crystallin.

  2001cited by this paper
• Photooxidation of Lens Proteins with Xanthurenic Acid: A Putative Chromophore for Cataractogenesis¶

  2001cited by this paper
• Photochemically Modified α-Crystallin: A Model System for Aging in the Primate Lens¶

  2001cited by this paper
• Photochemically modified alpha-crystallin: a model system for aging in the primate lens.

  2001cited by this paper
• Non-oxidative modification of lens crystallins by kynurenine: a novel post-translational protein modification with possible relevance to ageing and cataract.

  2000cited by this paper
• Characterisation of the major autoxidation products of 3-hydroxykynurenine under physiological conditions

  2000cited by this paper
• Cysteine Is the Initial Site of Modification of α-Crystallin by Kynurenine

  2000cited by this paper
• Cysteine is the initial site of modification of alpha-crystallin by kynurenine.

  2000cited by this paper
• Identification of Glutathionyl-3-hydroxykynurenine Glucoside as a Novel Fluorophore Associated with Aging of the Human Lens*

  1999cited by this paper
• UV filter compounds in human lenses: the origin of 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-beta-D-glucoside.

  1999cited by this paper
• Oxidation products of 3-hydroxykynurenine bind to lens proteins: relevance for nuclear cataract.

  1997cited by this paper
• Xanthurenic acid derivative formation in the lens is responsible for senile cataract in humans

  1996cited by this paper
• PHOTOLYSIS OF INTACT YOUNG HUMAN, BABOON AND RHESUS MONKEY LENSES

  1994cited by this paper
• MODEL STUDIES ON THE PHOTOCHEMICAL PRODUCTION OF LENTICULAR FLUOROPHORES

  1994cited by this paper
• Ultraviolet filter compounds in human lenses: 3-hydroxykynurenine glucoside formation.

  1994cited by this paper
• A new UV‐filter compound in human lenses

  1994cited by this paper
• UV filters in human lenses: tryptophan catabolism.

  1993cited by this paper
• Cataract: Biochemistry, Epidemiology and Pharmacology

  1991cited by this paper
• A STUDY OF THE PHOTODYNAMIC EFFICIENCIES OF SOME EYE LENS CONSTITUENTS

  1991cited by this paper
• Mechanism of coloration of human lenses induced by near-ultraviolet-photo-oxidized 3-hydroxykynurenine.

  1990cited by this paper
• PHOTOCHEMICAL AND PHOTOPHYSICAL STUDIES ON HUMAN LENS CONSTITUENTS

  1990cited by this paper
• TIME RESOLVED SPECTROSCOPIC STUDIES ON THE INTACT HUMAN LENS

  1990cited by this paper
• Photolytic changes in lens proteins.

  1984cited by this paper
• Red fluorescence in older and brunescent human lenses.

  1979cited by this paper
• Oxidative changes in human lens proteins during senile nuclear cataract formation.

  1977cited by this paper
• Changes in human lens proteins during nuclear cataract formation.

  1977cited by this paper
• Spectroscopic Evaluation and Classification of the Normal, Aging, and Cataractous Lens. (With 1 color plate)

  1976cited by this paper
• Changes to the proteins of the human lens nucleus in cataract.

  1974cited by this paper

• Cytoprotective Compounds in the Primate Eye: Baseline Metabolomic Profiles of Macaca fascicularis Ocular Tissues

  2025cites this paper
• N-formylkynurenine but not kynurenine enters a nucleophile-scavenging branch of the immune-regulatory kynurenine pathway

  2024cites this paper
• Immunomodulatory actions of a kynurenine-derived endogenous electrophile

  2022cites this paper
• Proton-coupled electron transfer as the mechanism of reaction between triplet state of kynurenic acid and tryptophan

  2020cites this paper
• UV-A induced damage to lysozyme via Type I photochemical reactions sensitized by kynurenic acid.

  2019cites this paper
• Ultrafast excited state decay of natural UV filters: from intermolecular hydrogen bonds to a conical intersection.

  2018cites this paper
• Dimerization and oxidation of tryptophan in UV‐A photolysis sensitized by kynurenic acid

  2017cites this paper
• Spatial distribution of metabolites in the human lens.

  2016cites this paper
• Mechanisms of photostability in kynurenines: a joint electronic-structure and dynamics study.

  2015cites this paper
• Photosensitizing Activity of Endogenous Eye Lens Chromophores: An Attempt to Unravel Their Contributions to Photo‐Aging and Cataract Disease

  2015cites this paper
• Metabolomic composition of normal aged and cataractous human lenses.

  2015cites this paper
• UVA Light-excited Kynurenines Oxidize Ascorbate and Modify Lens Proteins through the Formation of Advanced Glycation End Products

  2014cites this paper
• Photochemistry of aqueous solutions of kynurenic acid and kynurenine yellow

  2013cites this paper
• The therapeutic effect of mitochondria-targeted antioxidant SkQ1 and Cistanche deserticola is associated with increased levels of tryptophan and kynurenine in the rat lens

  2012cites this paper
• Photochemical properties of UV Filter molecules of the human eye.

  2011cites this paper
• Antioxidative properties of nitroxyl radicals and hydroxyamines in reactions with triplet and deaminated kynurenine

  2010cites this paper
• Photophysics and photochemistry of the UV filter kynurenine covalently attached to amino acids and to a model protein.

  2010cites this paper
• Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells.

  2010cites this paper
• Photoinduced tautomeric transformations of xanthurenic acid.

  2010cites this paper
• Ultrafast excited-state dynamics of kynurenine, a UV filter of the human eye.

  2009cites this paper
• Kinetics and mechanism of thermal decomposition of kynurenines and biomolecular conjugates: ramifications for the modification of mammalian eye lens proteins.

  2009cites this paper
• Efficient ytterbium triflate catalyzed microwave-assisted synthesis of 3-acylacrylic acid building blocks.

  2008cites this paper
• Photochemical and thermal reactions of kynurenines

  2008cites this paper
• Deaminated UV filter 3-hydroxykynurenine O-beta-D-glucoside is found in cataractous human lenses.

  2008cites this paper
• Photoactivity of kynurenine-derived UV filters.

  2008cites this paper
• Nucleophilicities of amino acids and peptides.

  2007cites this paper