Cardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury-associated coagulopathy in mice.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Blood

• Publication date

  2016-06-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/blood-2015-12-688838PMID 27002118PMCID PMC4891956
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Traumatic Brain Injury and Mitochondrial Dysfunction

  2015cited by this paper
• Brain-derived microparticles induce systemic coagulation in a murine model of traumatic brain injury.

  2015cited by this paper
• Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

  2015cited by this paper
• The diversity of platelet microparticles

  2015cited by this paper
• Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation.

  2014cited by this paper
• Elevated Levels of Plasma Mitochondrial DNA DAMPs Are Linked to Clinical Outcome in Severely Injured Human Subjects

  2013cited by this paper
• Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells.

  2013cited by this paper
• Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

  2013cited by this paper
• Traumatic Brain Injury-Associated Coagulopathy

  2012cited by this paper
• Global lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of acute brain injury

  2012cited by this paper
• Correlation between coagulopathy and outcome in severe head trauma in neurointensive care and trauma units.

  2011cited by this paper
• Validating the incidence of coagulopathy and disseminated intravascular coagulation in patients with traumatic brain injury – analysis of 242 cases

  2011cited by this paper
• Severity of head injury is associated with increased risk of coagulopathy in combat casualties.

  2011cited by this paper
• Acute Coagulopathy in Isolated Blunt Traumatic Brain Injury

  2010cited by this paper
• Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury

  2009cited by this paper
• Coagulopathy in severe traumatic brain injury: a prospective study.

  2009cited by this paper
• Lactadherin and clearance of platelet-derived microvesicles.

  2008cited by this paper
• Coagulation disorders after traumatic brain injury

  2008cited by this paper
• Development of a calibrated automated thrombography based thrombin generation test in mouse plasma

  2007cited by this paper
• Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis

  2007cited by this paper
• A new activated factor X-based clotting method with improved specificity for procoagulant phospholipid

  2003cited by this paper
• Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production*

  2003cited by this paper
• Induction of cell death by sera from patients with acute brain injury as a mechanism of production of autoantibodies.

  2002cited by this paper
• Antibodies to brain antigens following stroke

  2001cited by this paper
• Cardiolipin binds nonyl acridine orange by aggregating the dye at exposed hydrophobic domains on bilayer surfaces

  2001cited by this paper
• Association between the endoplasmic reticulum and mitochondria of yeast facilitates interorganelle transport of phospholipids through membrane contact.

  1999cited by this paper
• Experience with antithrombin concentrates in neurotrauma patients.

  1997cited by this paper
• Heterogeneity of Unfractionated Heparins Studied in Connection with Species, Source, and Production Processes

  1997cited by this paper
• Evidence for early supply independent mitochondrial dysfunction in patients developing multiple organ failure after trauma.

  1997cited by this paper
• Phospholipid composition of highly purified mitochondrial outer membranes of rat liver and Neurospora crassa. Is cardiolipin present in the mitochondrial outer membrane?

  1997cited by this paper
• Annexin V inhibition of factor IXa-catalyzed factor X activation on human platelets and on negatively-charged phospholipid vesicles.

  1996cited by this paper
• Blunt brain injury activates the coagulation process.

  1996cited by this paper
• Analysis of mitochondrial morphology and function with novel fixable fluorescent stains.

  1996cited by this paper
• Evidence that phosphatidylserine is imported into mitochondria via a mitochondria-associated membrane and that the majority of mitochondrial phosphatidylethanolamine is derived from decarboxylation of phosphatidylserine

  1995cited by this paper
• Ca(2+)-dependent binding of endonexin (annexin IV) to membranes: analysis of the effects of membrane lipid composition and development of a predictive model for the binding interaction.

  1994cited by this paper
• Cardiolipin-protein complexes and initiation of complement activation after coronary artery occlusion.

  1994cited by this paper
• Calcium-dependent annexin V binding to phospholipids: stoichiometry, specificity, and the role of negative charge.

  1993cited by this paper
• Phospholipid binding of annexin V: effects of calcium and membrane phosphatidylserine content.

  1992cited by this paper
• Delayed brain injury after head trauma: significance of coagulopathy.

  1992cited by this paper
• Microsurgery of the Cervical Spine

  1992cited by this paper
• Use of annexin-V to demonstrate the role of phosphatidylserine exposure in the maintenance of haemostatic balance by endothelial cells.

  1992cited by this paper
• Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers.

  1990cited by this paper
• Improved methods to isolate and subfractionate rat liver mitochondria. Lipid composition of the inner and outer membrane.

  1990cited by this paper
• Intravascular coagulation: a common phenomenon in minor experimental head injury.

  1981cited by this paper
• Delayed and recurrent intracranial hematomas related to disseminated intravascular clotting and fibrinolysis in head injury.

  1980cited by this paper
• Phosphatidylserine biosynthesis in mitochondria from the Morris 7777 hepatoma.

  1979cited by this paper
• Phospholipid content of mitochondrial and microsomal membranes from Morris hepatomas of varying growth rates.

  1979cited by this paper
• ON THE STRUCTURE OF CARDIOLIPIN.

  1964cited by this paper

• Unique Pattern of Coagulopathy Among Patients With Severe Traumatic Brain Injury: A Principal Component Analysis of Hemorrhagic Shock Trials.

  2026cites this paper
• A Machine Learning–3D Microvessel Platform Identifies Kinase Targets Restoring Blood-Brain-Barrier Endothelial Integrity

  2025cites this paper
• Bone marrow–derived emergency monopoiesis drives brain–lung axis injury after traumatic brain injury via IL-1

  2025cites this paper
• Bispecific self-assembled peptides as supra-growth factors for preventing endotheliopathy and improving survival of traumatic brain injury in mice

  2025cites this paper
• Research progress on blood therapy for anti-aging.

  2025cites this paper
• Developmental Endothelial Locus 1 Reduces Traumatic Brain Injury-Induced Endotheliopathy and Dysregulated Coagulation in Mice.

  2025cites this paper
• Astrocyte–microglia crosstalk in subarachnoid hemorrhage: mechanisms and treatments

  2025influential citation
• Extracellular mitochondria contribute to acute lung injury via disrupting macrophages after traumatic brain injury

  2025cites this paper
• Metabolically aberrant extracellular mitochondria induce oxidative endotheliopathy in traumatic brain injury

  2025cites this paper
• Deciphering Platelets: Are They Cells or an Evolved Form of Extracellular Vesicles?

  2025cites this paper
• Brain-derived extracellular vesicles mediate systemic coagulopathy and inflammation after traumatic brain injury.

  2024cites this paper
• The Role of Extracellular Vesicles and Microparticles in Central Nervous System Disorders: Mechanisms, Biomarkers, and Therapeutic Potential

  2024cites this paper
• Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome.

  2024cites this paper
• Mitochondrial Extracellular Vesicles: A Promising Avenue for Diagnosing and Treating Lung Diseases.

  2024cites this paper
• Microglia-induced neuroinflammation in hippocampal neurogenesis following traumatic brain injury

  2024cites this paper
• Relationship between coagulopathy score and ICU mortality: Analysis of the MIMIC-IV database

  2024cites this paper
• EASIX is an effective marker in predicting mortality of traumatic brain injury patients

  2024cites this paper
• Extracellular vesicles in disorders of hemostasis following traumatic brain injury

  2024cites this paper
• When Our Best Friend Becomes Our Worst Enemy: The Mitochondrion in Trauma, Surgery, and Critical Illness

  2024cites this paper
• β2-glycoprotein I promotes the clearance of circulating mitochondria

  2024cites this paper
• MPs-ACT, an Assay to Evaluate the Procoagulant Activity of Microparticles

  2023cites this paper
• Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic

  2023cites this paper
• Roles and therapeutic potential of different extracellular vesicle subtypes on traumatic brain injury

  2023influential citation
• Platelets from patients with myeloproliferative neoplasms have increased numbers of mitochondria that are hypersensitive to depolarization by thrombin

  2023cites this paper
• MPC-n (IgG) improves long-term cognitive impairment in the mouse model of repetitive mild traumatic brain injury

  2023cites this paper
• Role of circulating mitochondria in venous thrombosis in glioblastoma.

  2023cites this paper
• Bidirectional Communication Between the Brain and Other Organs: The Role of Extracellular Vesicles

  2023cites this paper
• Neutrophil extracellular traps contribute to coagulopathy after traumatic brain injury

  2023cites this paper
• Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation

  2022influential citation
• Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke

  2022cites this paper
• Exploration of cerebral vasospasm from the perspective of microparticles

  2022cites this paper
• Extracellular Mitochondria Activate Microglia and Contribute to Neuroinflammation in Traumatic Brain Injury

  2022cites this paper
• Why are bleeding trauma patients still dying? Towards a systems hypothesis of trauma

  2022cites this paper
• Immune dysfunction following severe trauma: A systems failure from the central nervous system to mitochondria

  2022cites this paper
• Gastric cancer cell-derived extracellular vesicles disrupt endothelial integrity and promote metastasis.

  2022cites this paper
• Detecting Traumatic Brain Injury-Induced Coagulopathy: What We Are Testing and What We Are Not.

  2022cites this paper
• Brain-Derived Extracellular Vesicles Induce Vasoconstriction and Reduce Cerebral Blood Flow in Mice

  2022cites this paper
• Extrusion of mitochondria: Garbage clearance or cell–cell communication signals?

  2022cites this paper
• Acrolein Induces Systemic Coagulopathy via Autophagy-dependent Secretion of von Willebrand Factor in Mice after Traumatic Brain Injury

  2021cites this paper
• Cardiolipin, Mitochondria, and Neurological Disease

  2021cites this paper
• The influence of hydrogen ions on coagulation in traumatic brain injury, explored by molecular dynamics

  2021cites this paper
• Platelets fuel mesenchymal stem cells by providing live mitochondria

  2021cites this paper
• Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst

  2021cites this paper
• Platelet Phagocytosis via P‐selectin Glycoprotein Ligand 1 and Accumulation of Microparticles in Systemic Sclerosis

  2021cites this paper
• The emerging therapeutic potential of extracellular vesicles in trauma

  2021cites this paper
• The role of Extracellular Vesicles in Traumatic Brain Injury-induced Acute Lung Injury.

  2021cites this paper
• Brain-derived extracellular vesicles mediated coagulopathy, inflammation and apoptosis after sepsis.

  2021cites this paper
• Anticoagulation Targeting Membrane-Bound Anionic Phospholipids Improved Outcomes of Traumatic Brain Injury in Mice.

  2021cites this paper
• Thromboembolic Prophylaxis in Traumatic Brain Injury

  2021cites this paper
• Immediate Postoperative Coagulopathy Predicts the Long-term Survival of Traumatic Brain Injury Patients: a Retrospective Cohort Study

  2021cites this paper
• Traumatic-Induced Coagulopathy as a Systems Failure: A New Window into Hemostasis

  2020cites this paper
• Death after discharge: prognostic model of 1-year mortality in traumatic brain injury patients undergoing decompressive craniectomy

  2020cites this paper
• Links between thrombosis and inflammation in traumatic brain injury.

  2020influential citation
• Effect of Phosphatidylcholine Nanosomes on Phospholipid Composition of the Plasma Membranes in Liver Cells and Blood Serum in Experimental Atherosclerosis

  2020cites this paper
• Oxidative Stress and Preeclampsia-Associated Prothrombotic State

  2020cites this paper
• Coagulopathy on the first postoperative day predicting the long-term survival of traumatic brain injury patients

  2020cites this paper
• University of Birmingham Spectroscopic detection of traumatic brain injury severity and biochemistry from the retina

  2020cites this paper
• Traumatic Brain Injury-Induced Coagulopathy

  2020cites this paper
• Platelet Extracellular Vesicles: Beyond the Blood.

  2020cites this paper
• Diverse activities of von Willebrand factor in traumatic brain injury and associated coagulopathy

  2020cites this paper
• Conformation-Dependent Blockage of Activated VWF Improved Outcomes of Traumatic Brain Injury in Mice.

  2020cites this paper
• Incidence of Antithrombin Deficiency and Anti-Cardiolipin Antibodies After Severe Traumatic Brain Injury: A Prospective Cohort Study

  2020cites this paper
• Mitochondrial damage & lipid signaling in traumatic brain injury.

  2020cites this paper
• Inflammation mediated platelet hyperactivity in aging.

  2020cites this paper
• The C291R Tau Variant Forms Different Types of Protofibrils

  2020cites this paper
• In vivo Two-Photon Imaging Reveals Acute Cerebral Vascular Spasm and Microthrombosis After Mild Traumatic Brain Injury in Mice

  2020cites this paper
• Platelet‐derived extracellular vesicles convey mitochondrial DAMPs in platelet concentrates and their levels are associated with adverse reactions

  2019cites this paper
• Extracellular Mitochondria in Traumatic Brain Injury Induced Coagulopathy

  2019cites this paper
• The Role of Cardiolipin and Mitochondrial Damage in Kidney Transplant

  2019cites this paper
• Brain-Derived Microparticles (BDMPs) Contribute to Neuroinflammation and Lactadherin Reduces BDMP Induced Neuroinflammation and Improves Outcome After Stroke

  2019cites this paper
• Blood Failure: Pathophysiology and Diagnosis

  2019cites this paper
• Placenta-derived extracellular vesicles induce preeclampsia in mouse models

  2019cites this paper
• TNF-alpha driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging.

  2019cites this paper
• Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA

  2019cites this paper
• Sources of Pathogenic Nucleic Acids in Systemic Lupus Erythematosus

  2019cites this paper
• Current state of transfusion in traumatic brain injury and associated coagulopathy

  2019cites this paper
• Extracellular mitochondria released from traumatized brains induced platelet procoagulant activity

  2019cites this paper
• Detection of brain specific cardiolipins in plasma after experimental pediatric head injury

  2019cites this paper
• Metabolic perturbations after pediatric TBI: It's not just about glucose

  2019cites this paper
• Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations

  2019cites this paper
• Lipidomics Detection of Brain Cardiolipins in Plasma Is Associated With Outcome After Cardiac Arrest

  2019cites this paper
• Removal of destructive brain-borne microdust.

  2018cites this paper
• Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury.

  2018cites this paper
• Platelet dysfunction in the perioperative and critical care setting

  2018cites this paper
• Cardiolipin activates antigen‐presenting cells via TLR2‐PI3K‐PKN1‐AKT/p38‐NF‐kB signaling to prime antigen‐specific naïve T cells in mice

  2018cites this paper
• Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice.

  2018cites this paper
• von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury.

  2018cites this paper
• Hemorrhagic blood failure: Oxygen debt, coagulopathy, and endothelial damage

  2017cites this paper
• Heart Interaction : Cardiac Complications After Stroke − Brain

  2017cites this paper
• Mitochondrial damage‐associated molecular patterns in blood transfusion products

  2017cites this paper
• Cardiolipin in Central Nervous System Physiology and Pathology

  2017cites this paper
• Microparticle and mitochondrial release during extended storage of different types of platelet concentrates

  2017cites this paper
• The release of microparticles and mitochondria from RAW 264.7 murine macrophage cells undergoing necroptotic cell death in vitro

  2017cites this paper
• Cellular microparticles and pathophysiology of traumatic brain injury

  2017influential citation
• Brain–Heart Interaction: Cardiac Complications After Stroke

  2017cites this paper