Ligand content-dependent exocytosis governs the blood-brain barrier transcytosis of nanocarriers.

The blood-brain barrier (BBB) penetration efficiency of nanocarriers is restricted by limited exocytosis to the brain parenchyma. This study demonstrates that exocytosis efficiency initially increases and subsequently decreases with increasing ligand content. Therefore, optimizing ligand content in brain-targeted nanocarriers is crucial to enhance exocytosis and transcytosis across the BBB.

• Publication year

  2026

• Venue

  Nanoscale

• Publication date

  2026-02-05

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1039/d5nr05008aPMID 41642083
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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