A longitudinal study on the development trajectory of post-stroke cognition: based on group-based trajectory model.

OBJECTIVE This study aimed to identify the different development trajectories of post-stroke cognition and the influential factors in stroke patients based on the group-based trajectory model. DESIGN A longitudinal study. METHODS This longitudinal cohort study recruited 1060 stroke patients from three hospitals from September 2021 to February 2023 and completed three follow-up visits at 1 month, 3 months, and 6 months, respectively. Based on the group-based trajectory model, we used the longitudinal changes of the Mini-Mental State Examination to fit the continuous dynamic development trajectory of post-stroke cognition over time in patients. RESULTS A total of 655 stroke patients completed the follow-up in this study. The result of the study shows that the cognitive development trajectory after stroke can be divided into four subgroups, namely the "persistent severe post-stroke cognitive impairment (PSCI) group" "persistent mild PSCI group" "PSCI risk group" and "normal cognitive group". CONCLUSION There is heterogeneity in the development trajectory of post-stroke cognition based on the group-based trajectory model. It is necessary to focus on the characteristics of the development trajectory of different subgroups, which helps to more accurately distinguish the populations at risk, to provide more effective monitoring and interventions.

• Publication year

  2026

• Venue

  Neurological Research

• Publication date

  2026-02-08

• Fields of study

  Medicine

• Identifiers
  DOI 10.1080/01616412.2026.2628606PMID 41655236
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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