SCIENCE@home

Antiarrhythmics Management During Electrophysiology Procedures: A Stepwise Approach.

G. Mugnai,Davide Genovese,Francesco Santoro,L. Tomasi,Luigi Di Biase,Matteo Anselmino,Massimo Tritto,Antonio Frontera,A. Curcio,A. Rapacciuolo,F. Migliore

Published 2026 in Cardiovascular Electrophysiology

ABSTRACT

This review examines the protocols and rationale for stopping antiarrhythmic drugs (AADs) before interventional electrophysiology (EP) procedures to establish a drug-free baseline, ensuring diagnostic accuracy and procedural success. The review provided a detailed analysis of procedure-specific AADs washout requirements for supraventricular tachycardia, atrial fibrillation, and ventricular tachycardia ablation, and a comprehensive, drug-by-drug guide to calculate washout periods, based on pharmacokinetic and pharmacodynamic principles. This guide details the half-life, metabolism, and elimination pathways for all major AAD classes, and gives specific, actionable recommendations for adjusting wash-out times based on patient-specific factors, including age, renal function, and hepatic impairment. The aim is to provide clinicians with evidence-based guidance for standardizing AADs washout, thereby improving the safety and success of interventional EP procedures.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-72 of 72 references · Page 1 of 1

CITED BY

  • No citing papers are available for this paper.

Showing 0-0 of 0 citing papers · Page 1 of 1