Direct Photoexcitation Enables Nickel-Catalyzed C(sp3)-C(sp3) Coupling of α-Bromonitriles with Alkylzirconocenes.

We report a visible-light-mediated nickel-catalyzed C(sp3)-C(sp3) cross-coupling between α-bromonitriles and alkylzirconocene reagents enabled by a direct photoexcitation strategy. Alkyl radicals are generated from in situ formed alkylzirconocenes under visible-light irradiation and efficiently incorporated into a nickel catalytic cycle to forge C(sp3)-C(sp3) bonds under mild conditions. The reaction accommodates a range of α-bromonitriles and alkene-derived alkyl fragments, and its synthetic utility is demonstrated by scale-up experiments and downstream derivatizations.

• Publication year

  2026

• Venue

  Organic Letters

• Publication date

  2026-02-08

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.orglett.6c00085PMID 41656746
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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