Discovery and Development of Antibacterial Peptidoglycan Hydrolase Inhibitors.

The growing number of bacterial infections and the rise of antibiotic resistance require approaches for antimicrobial development. Peptidoglycan, essential for maintaining the integrity and shape of the bacterial cell wall, is regulated by the coordinated activity of peptidoglycan synthesis and remodeling enzymes. While peptidoglycan synthesis enzymes have served as antibiotic targets for decades, peptidoglycan hydrolases have remained largely underexplored. Here, we review recent advances in the development of small-molecule inhibitors of peptidoglycan hydrolases as antimicrobial targets.

• Publication year

  2026

• Venue

  ACS Infectious Diseases

• Publication date

  2026-02-08

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acsinfecdis.5c00980PMID 41656975
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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