Insulin treatment normalizes retinal neuroinflammation but not markers of synapse loss in diabetic rats.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Experimental Eye Research

• Publication date

  2014-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.exer.2014.06.005PMID 24931083PMCID PMC4122586
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diabetic Retinopathy and Other Ocular Findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

  2013cited by this paper
• Inflammation and Pharmacological Treatment in Diabetic Retinopathy

  2013cited by this paper
• The effects of age and Cx3cr1 deficiency on retinal microglia in the Ins2(Akita) diabetic mouse.

  2013cited by this paper
• Effects of insulin monotherapy on body weight, composition, and fat distribution in newly diagnosed patients with Type 2 diabetes mellitus (新诊断的2型糖尿病患者使用胰岛素单药治疗后对体重、身体组成以及脂肪分布的影响)

  2013cited by this paper
• Biomarkers in Diabetic Retinopathy and the Therapeutic Implications

  2013cited by this paper
• Early visual deficits in streptozotocin-induced diabetic long evans rats.

  2013cited by this paper
• Animal Models of Diabetic Retinopathy: Summary and Comparison

  2013cited by this paper
• Metabolic memory: mechanisms and implications for diabetic retinopathy.

  2012cited by this paper
• Neurodegeneration of the retina in type 1 diabetic patients.

  2012cited by this paper
• Early distal axonopathy of the visual pathway in experimental diabetes.

  2012cited by this paper
• Diabetic retinopathy.

  2012cited by this paper
• Metabolic Memory and Chronic Diabetes Complications: Potential Role for Epigenetic Mechanisms

  2012cited by this paper
• Decrease in retinal neuronal cells in streptozotocin-induced diabetic mice

  2012cited by this paper
• Epigenetics: deciphering its role in diabetes and its chronic complications

  2011cited by this paper
• The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy.

  2011cited by this paper
• Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome

  2011cited by this paper
• Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes

  2011cited by this paper
• Multi-Modal Proteomic Analysis of Retinal Protein Expression Alterations in a Rat Model of Diabetic Retinopathy

  2011cited by this paper
• Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss.

  2011cited by this paper
• Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy.

  2011cited by this paper
• Inflammation in diabetic retinopathy.

  2011cited by this paper
• Epigenetic phenomena linked to diabetic complications

  2010cited by this paper
• A multistep validation process of biomarkers for preclinical drug development

  2010cited by this paper
• Visual Dysfunction Associated with Diabetic Retinopathy

  2010cited by this paper
• Baicalein reduces inflammatory process in a rodent model of diabetic retinopathy.

  2009cited by this paper
• Effect of N‐acetylcysteine on the early expression of inflammatory markers in the retina and plasma of diabetic rats

  2009cited by this paper
• Microglial activation in human diabetic retinopathy.

  2008cited by this paper
• Diabetes downregulates presynaptic proteins and reduces basal synapsin I phosphorylation in rat retina

  2008cited by this paper
• Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response

  2008cited by this paper
• Early inner retinal dysfunction in streptozotocin-induced diabetic rats.

  2008cited by this paper
• Retinal ganglion cells in diabetes

  2008cited by this paper
• Microglial changes occur without neural cell death in diabetic retinopathy.

  2007cited by this paper
• The Heterogeneity of Diabetes

  2007cited by this paper
• Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas.

  2006cited by this paper
• Diabetic Retinopathy

  2006cited by this paper
• The Ins2Akita mouse as a model of early retinal complications in diabetes.

  2005cited by this paper
• Expression of acute-phase response proteins in retinal Müller cells in diabetes.

  2005cited by this paper
• A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat.

  2003cited by this paper
• Body composition in adults with Type 1 diabetes at onset and during the first year of insulin therapy

  2002cited by this paper
• Early retinal damage in experimental diabetes: electroretinographical and morphological observations.

  2002cited by this paper
• Controlling the false discovery rate in behavior genetics research.

  2001cited by this paper
• Influence of intensive diabetes treatment on body weight and composition of adults with type 1 diabetes in the Diabetes Control and Complications Trial.

  2001cited by this paper
• [Diabetic retinopathy].

  2001cited by this paper
• Glial reactivity, an early feature of diabetic retinopathy.

  2000cited by this paper
• Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group.

  2000cited by this paper
• Spectrophotometric assay for measuring branched-chain amino acids.

  2000cited by this paper
• Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin.

  1998cited by this paper
• Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group.

  1998cited by this paper
• Increase in synaptophysin immunoreactivity following cortical infarction.

  1992cited by this paper
• Structure of the macroglia of the retina: Sharing and division of labour between astrocytes and Müller cells

  1991cited by this paper
• Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease.

  1989cited by this paper
• Progression of Incipient Diabetic Retinopathy During Good Glycemic Control

  1987cited by this paper

• Accumulation of branched-chain amino acids deteriorates the neuroinflammatory response of Müller cells in diabetic retinopathy via leucine/Sestrin2-mediated sensing of mTOR signaling

  2024cites this paper
• Glial Fibrillary Acidic Protein’s Usefulness as an Astrocyte Biomarker Using the Fully Automated LUMIPULSE® System

  2024cites this paper
• Branched-Chain Amino Acids Metabolism and Their Roles in Retinopathy: From Relevance to Mechanism

  2023cites this paper
• Characterization of Diabetic Retinopathy in Two Mouse Models and Response to a Single Injection of Anti-Vascular Endothelial Growth Factor

  2022cites this paper
• Neurovascular Unit: A New Target for Treating Early Stages of Diabetic Retinopathy

  2021cites this paper
• The role of inflammation and neurodegeneration in diabetic macular edema

  2021cites this paper
• Neuromodulation Induced by Sitagliptin: A New Strategy for Treating Diabetic Retinopathy

  2021cites this paper
• Effect of basal insulin supplement therapy on diabetic retinopathy in short‐duration type 2 diabetes: A one‐year randomized parallel‐group trial†

  2019influential citation
• Molecular Mechanisms Mediating Diabetic Retinal Neurodegeneration: Potential Research Avenues and Therapeutic Targets

  2018cites this paper
• Neurodegeneration in diabetic retinopathy: Potential for novel therapies

  2017cites this paper
• Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy

  2017cites this paper
• Intranasal insulin treatment alleviates methamphetamine induced anxiety-like behavior and neuroinflammation.

  2017cites this paper
• Neuroinflammatory responses in diabetic retinopathy

  2015cites this paper
• Protective effect of a Chinese Medicine formula He-Ying-Qing-Re Formula on diabetic retinopathy.

  2015cites this paper
• The Role of Insulin and Incretins in Neuroinflammation and Neurodegeneration

  2014cites this paper
• Special Topic: Diabetic Retinopathy Special Edition Diabetic Retinopathy: Recent Advances towards Understanding Neurodegeneration and Vision Loss

  year unknowncites this paper