Impact of daily administration of teriparatide on the histological pattern of testicular structure in adult male rats

<p><strong>Aim </strong>Teriparatide, a synthetic analog of the active fragment of human parathyroid hormone (PTH 1&ndash;34), is a clinically approved anabolic treatment for osteoporosis. While its bone-forming capacity is well-documented, evidence regarding its systemic safety, particularly in relation to male reproductive health, remains limited.</p> <p><strong>Aim:</strong> This study was designed to investigate the histological consequences of prolonged teriparatide exposure on testicular architecture in adult male rats, addressing a critical gap in its toxicological profile.</p> <p><strong>Methods</strong> Twenty adult male albino rats were randomly allocated into two groups. The control group received subcutaneous saline (1 mL/kg/day), while and the treated group was administered teriparatide (10 &micro;g/kg/day) daily for 60 days. Testes were collected post-euthanasia, fixed in formalin, and processed for histological examination. Spermatogenic activity was assessed using Johnsen&rsquo;s scoring system, and morphometric parameters, including seminiferous tubule diameter and epithelial height, were quantified. Statistical significance was determined using the Mann&ndash;Whitney U test (p&le;0.05).</p> <p><strong>Results </strong>Histological findings revealed preserved cytoarchitecture with active spermatogenesis in control testes. The teriparatide-treated group exhibited significant degenerative changes, including epithelial detachment, interstitial edema, vascular congestion, and Leydig cell necrosis. Johnsen&rsquo;s scores were significantly reduced in the treated group (median = 4.5; IQR=1.5) compared to controls (median = 8.0; IQR=2.0; p&lt;0.001). Furthermore, Seminiferous tubule diameter and epithelial height were markedly decreased in the treated animals.</p> <p><strong>Conclusion </strong>The findings suggest that prolonged teriparatide exposure may impair permatogenesis and alter testicular structure. Re-evaluation of its reproductive safety is warranted, particularly for males of reproductive age.</p>

• Publication year

  2026

• Venue

  Medicinski glasnik

• Publication date

  2026-02-27

• Fields of study

  Not labeled

• Identifiers
  DOI 10.17392/2033-23-01
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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