Refined Model of Common Peroneal Nerve Injury and Regeneration: A Neurophysiological, Morphometric, and Functional Analysis in the adult Rat.

The common peroneal nerve lesion induces a specific peripheral nerve injury, characterized by a specific motor deficit with little animal burden. Although, it has been described in the 1980s, there is a lack of consistent outcome measurements in the literature. This study presents a refined common peroneal nerve injury model in Sprague Dawley rats with crush or transection injury. It introduces a morphometric muscle analysis, a refined videometric gait analysis and isometric force measurement, as well as testing the validity of outcome measures. The tibialis anterior muscle exhibited the largest physiological cross-sectional area, the highest muscle volume and wet weight. Crush injury showed significantly higher gait regeneration, a stronger twitch force and greater muscle masses compared to nerve transection. The introduced model offers shorter regeneration time, muscle-sparing access, and a high test validity for muscle mass, joint angle analysis, and isometric twitch force.

• Publication year

  2026

• Venue

  Brain Research Bulletin

• Publication date

  2026-03-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.brainresbull.2026.111805PMID 41780697
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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