Near UV and Visible Light-Induced Degradation of IgG2: Photo-Fenton Reaction in Citrate Buffer.

No abstract is available for this paper.

• Publication year

  2026

• Venue

  Pharmaceutical Research

• Publication date

  2026-03-03

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1007/s11095-026-04047-xPMID 41776150
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Near UV and Visible Light-Induced Degradation of Bovine Serum Albumin and a Monoclonal Antibody Mediated by Citrate Buffer and Fe(III): Reduction vs Oxidation Pathways.

  2024cited by this paper
• Physicochemical methods for disinfection of contaminated surfaces – a way to control infectious diseases

  2024cited by this paper
• Near UV light photo-degradation of lactate and related α-hydroxycarboxylates in the presence of Fe(III): formation of carbon dioxide radical anion.

  2024cited by this paper
• Near UV and visible light photo-degradation mechanisms in citrate buffer: one-electron reduction of peptide and protein disulfides promotes oxidation and cis/trans isomerization of unsaturated fatty acids of polysorbate 80.

  2022cited by this paper
• Comprative evaluation of Advanced Oxidation Processes (AOPs) for reducing SARS-CoV-2 viral load from campus sewage water

  2022cited by this paper
• Visible Light Induces Site-Specific Oxidative Heavy Chain Fragmentation of a Monoclonal Antibody (IgG1) Mediated by an Iron(III)-Containing Histidine Buffer.

  2022cited by this paper
• Near-UV and Visible Light Degradation of Iron (III)-Containing Citrate Buffer: Formation of Carbon Dioxide Radical Anion via Fragmentation of a Sterically Hindered Alkoxyl Radical.

  2022cited by this paper
• Metal Ion Interactions with mAbs: Part 2. Zinc-Mediated Aggregation of IgG1 Monoclonal Antibodies

  2021cited by this paper
• Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses

  2020cited by this paper
• Photo-Degradation of Therapeutic Proteins: Mechanistic Aspects

  2020cited by this paper
• Near UV and Visible Light Induce Iron-Dependent Photo-degradation Reactions in Pharmaceutical Buffers: Mechanistic and Product Studies.

  2020cited by this paper
• Effective elimination of fifteen relevant pharmaceuticals in hospital wastewater from Colombia by combination of a biological system with a sonochemical process.

  2019cited by this paper
• Susceptibility of protein therapeutics to spontaneous chemical modifications by oxidation, cyclization, and elimination reactions

  2019cited by this paper
• Oxidation mechanisms of amoxicillin and paracetamol in the photo-Fenton solar process.

  2019cited by this paper
• Efficient degradation of pharmaceutical micropollutants in water and wastewater by FeIII-NTA-catalyzed neutral photo-Fenton process.

  2019cited by this paper
• Optimization of photo-Fenton process for the treatment of prednisolone

  2018cited by this paper
• Mass-Spectrometry-Based Identification of Cross-Links in Proteins Exposed to Photo-Oxidation and Peroxyl Radicals Using 18O Labeling and Optimized Tandem Mass Spectrometry Fragmentation.

  2018cited by this paper
• Industrial bioprocessing perspectives on managing therapeutic protein charge variant profiles

  2018cited by this paper
• Removal of β-lactam antibiotics from pharmaceutical wastewaters using photo-Fenton process at near-neutral pH

  2018cited by this paper
• Analogies and differences among bacterial and viral disinfection by the photo-Fenton process at neutral pH: a mini review

  2018cited by this paper
• Effect of photo‐degradation on the structure, stability, aggregation, and function of an IgG1 monoclonal antibody

  2018cited by this paper
• Determination of the Acceptable Ambient Light Exposure during Drug Product Manufacturing for Long-Term Stability of Monoclonal Antibodies

  2018cited by this paper
• Drawbacks of Dialysis Procedures for Removal of EDTA

  2017cited by this paper
• Role of Buffers in Protein Formulations.

  2017cited by this paper
• Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer.

  2017cited by this paper
• Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance.

  2017cited by this paper
• Textile wastewater reuse after additional treatment by Fenton’s reagent

  2017cited by this paper
• Photo-Fenton treatment of valproate under UVC, UVA and simulated solar radiation.

  2017cited by this paper
• Peroxyl radical- and photo-oxidation of glucose 6-phosphate dehydrogenase generates cross-links and functional changes via oxidation of tyrosine and tryptophan residues.

  2017cited by this paper
• An Efficient and Rapid Method to Monitor the Oxidative Degradation of Protein Pharmaceuticals: Probing Tyrosine Oxidation with Fluorogenic Derivatization

  2017cited by this paper
• Photo-Fenton degradation of the pharmaceuticals ciprofloxacin and fluoxetine after anaerobic pre-treatment of hospital effluent

  2017cited by this paper
• Thiyl radicals and induction of protein degradation

  2016cited by this paper
• Microheterogeneity of therapeutic monoclonal antibodies is governed by changes in the surface charge of the protein

  2016cited by this paper
• Effect of ambient light on IgG1 monoclonal antibodies during drug product processing and development.

  2016cited by this paper
• Immunogenicity of Therapeutic Protein Aggregates.

  2016cited by this paper
• Quantitation of Site-Specific Glycosylation in Manufactured Recombinant Monoclonal Antibody Drugs.

  2016cited by this paper
• Charge heterogeneity: Basic antibody charge variants with increased binding to Fc receptors

  2016cited by this paper
• Site-Specific Hydrolysis Reaction C-Terminal of Methionine in Met-His during Metal-Catalyzed Oxidation of IgG-1.

  2016cited by this paper
• Method development for the separation of monoclonal antibody charge variants in cation exchange chromatography, Part II: pH gradient approach.

  2015cited by this paper
• Antibody glycosylation and its impact on the pharmacokinetics and pharmacodynamics of monoclonal antibodies and Fc-fusion proteins.

  2015cited by this paper
• Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics

  2015cited by this paper
• The Immunogenicity of Antibody Aggregates in a Novel Transgenic Mouse Model

  2015cited by this paper
• Investigation of antibody disulfide reduction and re-oxidation and impact to biological activities.

  2015cited by this paper
• Enhancement of a solar photo-Fenton reaction with ferric-organic ligands for the treatment of acrylic-textile dyeing wastewater.

  2015cited by this paper
• Metal ion interactions with mAbs: Part 1

  2015cited by this paper
• The application of advanced oxidation technologies to the treatment of effluents from the pulp and paper industry: a review

  2014cited by this paper
• Effect of ambient light on monoclonal antibody product quality during small‐scale mammalian cell culture process in clear glass bioreactors

  2014cited by this paper
• Hexyl glucoside and hexyl maltoside inhibit light-induced oxidation of tryptophan.

  2014cited by this paper
• Characterization of the degradation products of a color-changed monoclonal antibody: tryptophan-derived chromophores.

  2014cited by this paper
• Microchip zone electrophoresis for high-throughput analysis of monoclonal antibody charge variants.

  2014cited by this paper
• Implications of in-use photostability: proposed guidance for photostability testing and labeling to support the administration of photosensitive pharmaceutical products, part 1: drug products administered by injection.

  2013cited by this paper
• Pharmaceuticals as emerging contaminants and their removal from water. A review.

  2013cited by this paper
• Metal-catalyzed oxidation of protein methionine residues in human parathyroid hormone (1-34): formation of homocysteine and a novel methionine-dependent hydrolysis reaction.

  2013cited by this paper
• Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

  2013cited by this paper
• Role of surface exposed tryptophan as substrate generators for the antibody catalyzed water oxidation pathway.

  2013cited by this paper
• Biodegradability enhancement of a pesticide-containing bio-treated wastewater using a solar photo-Fenton treatment step followed by a biological oxidation process.

  2012cited by this paper
• Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

  2012cited by this paper
• Disulfide bond structures of IgG molecules

  2012cited by this paper
• Forced degradation of therapeutic proteins.

  2012cited by this paper
• Biologics Formulation Factors Affecting Metal Leachables from Stainless Steel

  2011cited by this paper
• Charge variants in IgG1

  2010cited by this paper
• Comparative evaluation of disodium edetate and diethylenetriaminepentaacetic acid as iron chelators to prevent metal-catalyzed destabilization of a therapeutic monoclonal antibody.

  2010cited by this paper
• Heterogeneous photo-Fenton treatment for the reduction of pharmaceutical contamination in Madrid rivers and ecotoxicological evaluation by a miniaturized fern spores bioassay.

  2010cited by this paper
• Effects of charge on antibody tissue distribution and pharmacokinetics.

  2010cited by this paper
• Stability of Protein Pharmaceuticals: An Update

  2010cited by this paper
• Reduced elimination of IgG antibodies by engineering the variable region.

  2010cited by this paper
• Elevated cleavage of human immunoglobulin gamma molecules containing a lambda light chain mediated by iron and histidine.

  2009cited by this paper
• Methionine, tryptophan, and histidine oxidation in a model protein, PTH: mechanisms and stabilization.

  2009cited by this paper
• Photoinduced degradation of 2,4-dichlorophenol in water: influence of various Fe(III) carboxylates

  2009cited by this paper
• Photocatalytic degradation of prions using the photo-Fenton reagent.

  2009cited by this paper
• Heterogeneity of monoclonal antibodies.

  2008cited by this paper
• Sequential solar photo-fenton-biological system for the treatment of winery wastewaters.

  2008cited by this paper
• Decontamination of soil washing wastewater using solar driven advanced oxidation processes.

  2008cited by this paper
• Protect from light: photodegradation and protein biologics.

  2007cited by this paper
• The incidence and significance of anti-natalizumab antibodies

  2007cited by this paper
• Neutralizing antibodies to biological therapies

  2007cited by this paper
• Pharmaceutical Photostability and Stabilization Technology

  2006cited by this paper
• Isolation and characterization of impurities in docetaxel.

  2006cited by this paper
• Oxidatively modified autoantigens in autoimmune diseases.

  2006cited by this paper
• In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.

  2005cited by this paper
• Selective site-specific fenton oxidation of methionine in model peptides: evidence for a metal-bound oxidant.

  2004cited by this paper
• CTL recognition of an altered peptide associated with asparagine bond rearrangement. Implications for immunity and vaccine design.

  1996cited by this paper
• How to measure and predict the molar absorption coefficient of a protein

  1995cited by this paper
• Radiolytic reduction of protein and nonprotein disulfides in the presence of formate: a chain reaction.

  1991cited by this paper
• CO2.- radical induced cleavage of disulfide bonds in proteins. A gamma-ray and pulse radiolysis mechanistic investigation.

  1990cited by this paper
• INFLUENCE OF THE LOCATION OF TRYPTOPHANYL RESIDUES IN PROTEINS ON THEIR PHOTOSENSITIVITY

  1984cited by this paper

• No citing papers are available for this paper.