Vitamin D3 analogs: effect on leukemic clonal growth and differentiation, and on serum calcium levels.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0145-2126(94)00065-IPMID 7837819
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 1,25(OH)2-16ene-vitamin D3 is a potent antileukemic agent with low potential to cause hypercalcemia.

  1994cited by this paper
• EB 1089, a novel vitamin D analogue, has strong antiproliferative and differentiation inducing effects on cancer cells.

  1993cited by this paper
• A vitamin D analogue (EB1089) inhibits parathyroid hormone-related peptide production and prevents the development of malignancy-associated hypercalcemia in vivo.

  1993cited by this paper
• Effect of substituting fluorine for hydrogen at C-26 and C-27 on the side chain of 1,25-dihydroxyvitamin D3.

  1993cited by this paper
• EB1089: a new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro.

  1992cited by this paper
• Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid).

  1991cited by this paper
• A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients.

  1991cited by this paper
• Development of a novel 1,25(OH)2-vitamin D3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism.

  1991cited by this paper
• Structure-Function Studies on Analogues of 1α,25-Dihydroxyvitamin D3: Differential Effects on Leukemic Cell Growth, Differentiation, and Intestinal Calcium Absorption

  1990cited by this paper
• Novel vitamin D3 derivatives, 26-homo-delta 22-dehydro-1 alpha,25(S)-dihydroxyvitamin D3 and 26-homo-delta 22-dehydro-1 alpha,25(R)-dihydroxyvitamin D3: preferential activity in c-myc mRNA production and in induction of phenotypic differentiation of HL-60 cells.

  1990cited by this paper
• New active analogues of vitamin D with low calcemic activity.

  1990cited by this paper
• 1,25-Dihydroxy-16-ene-23-yne-vitamin D3 prolongs survival time of leukemic mice.

  1990cited by this paper
• Structure-function studies on analogues of 1 alpha,25-dihydroxyvitamin D3: differential effects on leukemic cell growth, differentiation, and intestinal calcium absorption.

  1990cited by this paper
• All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results.

  1990cited by this paper
• Effect of phenobarbital induction, charcoal treatment and storage on the spectral binding characteristics and NADPH-cytochrome P-450 reductase activity of hepatic microsomes.

  1990cited by this paper
• Novel vitamin D3 derivatives, 26-Homo-Δ22-dehydro-1α, 25(S)-dihydroxyvitamin D3 and 26-Homo-Δ22-dehydro-1α, 25(R)-dihydroxyvitamin D3: Preferential activity in c-myc mRNA production and in induction of phenotypic differentiation of HL-60 cells

  1990cited by this paper
• A synthetic analogue of vitamin D3, 22-oxa-1 alpha,25-dihydroxyvitamin D3, is a potent modulator of in vivo immunoregulating activity without inducing hypercalcemia in mice.

  1989cited by this paper
• Novel vitamin D analogs that modulate leukemic cell growth and differentiation with little effect on either intestinal calcium absorption or bone mobilization.

  1989cited by this paper
• Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia.

  1988cited by this paper
• Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia.

  1988cited by this paper
• Synthetic analogues of vitamin D3 with an oxygen atom in the side chain skeleton A trial of the development of vitamin D compounds which exhibit potent differentiation‐inducing activity without inducing hypercalcemia

  1987cited by this paper
• 24- and 26-homo-1,25-dihydroxyvitamin D3: preferential activity in inducing differentiation of human leukemia cells HL-60 in vitro.

  1987cited by this paper
• The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression.

  1987cited by this paper
• Treatment of myelodysplastic syndrome with 1.25‐dihydroxy‐vitamin D3

  1986cited by this paper
• SYNTHETIC STUDIES OF VITAMIN D ANALOGUES. VII. : SYNTHESIS OF 20-OXA-21-NORVITAMIN D3 ANALOGUES

  1986cited by this paper
• Vitamin D compounds. Effect on clonal proliferation and differentiation of human myeloid cells.

  1986cited by this paper
• 1,25-Dihydroxyvitamin D3: in vivo and in vitro effects on human preleukemic and leukemic cells.

  1985cited by this paper
• 1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells

  1984cited by this paper
• Treatment of advanced myelodysplastic syndrome with alfacalcidol.

  1984cited by this paper
• Biological activity of vitamin D3 derivatives in inducing differentiation of HL-60 human promyelocytic leukemia cells.

  1984cited by this paper
• Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues.

  1984cited by this paper
• 1 alpha,25-Dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL-60).

  1982cited by this paper
• Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.

  1981cited by this paper
• Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity.

  1978cited by this paper

• Demonstrative Experiment on the Favorable Effects of Static Electric Field Treatment on Vitamin D3-Induced Hypercalcemia

  2021cites this paper
• A novel vitamin D gene therapy for acute myeloid leukemia

  2020cites this paper
• Application of vitamin D and vitamin D analogs in acute myelogenous leukemia.

  2017cites this paper
• l‐Asparaginase‐mediated downregulation of c‐Myc promotes 1,25(OH)2D3‐induced myeloid differentiation in acute myeloid leukemia cells

  2017cites this paper
• Lyn, a tyrosine kinase closely linked to the differentiation status of primary acute myeloid leukemia blasts, associates with negative regulation of all-trans retinoic acid (ATRA) and dihydroxyvitamin D3 (VD3)-induced HL-60 cells differentiation

  2016cites this paper
• Vitamin D3: A Role in Dopamine Circuit Regulation, Diet-Induced Obesity, and Drug Consumption123

  2016cites this paper
• Chapter 88 – Hematological Malignancy

  2011cites this paper
• Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D₃.

  2011cites this paper
• Vitamin D and Hematologic Malignancies

  2011cites this paper
• Vitamin D3-driven signals for myeloid cell differentiation--implications for differentiation therapy.

  2010cites this paper
• Apc(MIN) modulation of vitamin D secosteroid growth control.

  2010cites this paper
• Differentiation therapy of leukemia: 3 decades of development.

  2009cites this paper
• Structure-based design of a superagonist ligand for the vitamin D nuclear receptor.

  2008cites this paper
• Induction of differentiation of myeloid leukemia cells in primary culture in response to lithocholic acid acetate, a bile acid derivative, and cooperative effects with another differentiation inducer, cotylenin A.

  2008cites this paper
• Enhancing effects of ceramide derivatives on 1,25-dihydroxyvitamin D(3)-induced differentiation of human HL-60 leukemia cells.

  2007cites this paper
• The Vitamin D analogue TX 527 blocks NF-κB activation in peripheral blood mononuclear cells of patients with Crohn's disease

  2007cites this paper
• 27-bishomo-Vitamin D 3 Analogs : A Unique Class of Potent Inhibitors of Proliferation of Prostate , Breast , and Hematopoietic Cancer Cells 1

  2006cites this paper
• Hematopoietic Cancer Cells Potent Inhibitors of Proliferation of Prostate , Breast , and Analogs : A Unique Class of 319-nor-26 , 27-bishomo-Vitamin D Updated

  2006cites this paper
• CHAPTER 27 – Differentiation Induction in Leukemia and Lymphoma

  2006cites this paper
• Responsiveness of human retinoblastoma and neuroblastoma models to a non-calcemic 19-nor Vitamin D analog.

  2005cites this paper
• CHAPTER 96 – Vitamin D and Hematological Malignancy

  2005cites this paper
• 1,25 dihydroxyvitamin d amplifies type a natriuretic peptide receptor expression and activity in target cells.

  2005cites this paper
• Translational study of vitamin D differentiation therapy of myeloid leukemia: effects of the combination with a p38 MAPK inhibitor and an antioxidant

  2005cites this paper
• 19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia.

  2005cites this paper
• Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones

  2004cites this paper
• Combined effect of vitamin D3 analogs and paclitaxel on the growth of MCF-7 breast cancer cells in vivo

  2004cites this paper
• Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs

  2004cites this paper
• Effectiveness of 1alpha-hydroxyvitamin D2 in inhibiting tumor growth in a murine transgenic pigmented ocular tumor model.

  2004cites this paper
• Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease.

  2003cites this paper
• Immunology of Uveal Melanoma: Immunosuppressive Factors and the Basis for Immunotherapy

  2003cites this paper
• Using Retinoblastoma Models to Develop New Treatment: Vitamin D Analogues

  2003cites this paper
• Vitamin D2 analog 19-nor-1,25-dihydroxyvitamin D2: antitumor activity against leukemia, myeloma, and colon cancer cells.

  2003cites this paper
• Cancer chemoprevention using natural vitamin D and synthetic analogs.

  2003cites this paper
• Vitamin D and vitamin D analogs as cancer chemopreventive agents.

  2003cites this paper
• Vitamin D 2 Analog 19-nor-1 , 25-Dihydroxyvitamin D 2 : Antitumor Activity Against Leukemia , Myeloma , and Colon Cancer Cells

  2003cites this paper
• Magnesium Deficiency: Effect on Bone and Mineral Metabolism in the Mouse

  2002cites this paper
• Toxicity and dose-response studies of 1alpha-hydroxyvitamin D2 in a retinoblastoma xenograft model.

  2002cites this paper
• 1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apc(min) Mouse.

  2002cites this paper
• Synergistic Effect of Vitamin D Derivatives and Retinoids on C2C12 Skeletal Muscle Cells

  2002cites this paper
• 1α, 25-(OH)2-D3 and its synthetic analogue decrease tumor load in the Apcmin mouse

  2002cites this paper
• Toxicity and Dose-Response Studies of 1-Hydroxyvitamin D 2 in a Retinoblastoma Xenograft Model

  2002cites this paper
• Vitamin D analogs in experimental leukemia and transplantation models

  2002cites this paper
• Induction of differentiation of human myeloid leukemia cells by novel synthetic neurotrophic pyrimidine derivatives.

  2001cites this paper
• Vitamin D(3) and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC.

  2001cites this paper
• Effects of vitamin D on the growth of normal and malignant B‐cell progenitors

  2001cites this paper
• Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells.

  2001cites this paper
• MC1288, a vitamin D analog, prevents acute graft-versus-host disease in rat bone marrow transplantation

  2001cites this paper
• Interaction of Two Novel 14‐Epivitamin D3 Analogs with Vitamin D3 Receptor‐Retinoid X Receptor Heterodimers on Vitamin D3 Responsive Elements

  2001cites this paper
• Biological Activity of CD‐Ring Modified 1α,25‐Dihydroxyvitamin D Analogues: C‐Ring and Five‐Membered D‐Ring Analogues

  2000cites this paper
• 1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3 and 1alpha,25-dihydroxy-16-ene-23-yne-20-epi-vitamin D3: analogs of 1alpha,25-dihydroxyvitamin D3 that resist metabolism through the C-24 oxidation pathway are metabolized through the C-3 epimerization pathway.

  2000cites this paper
• 1α,25-Dihydroxy-16-ene-23-yne-vitamin D3 and 1α,25-Dihydroxy-16-ene-23-yne-20-epi-vitaminD3: Analogs of 1α,25-Dihydroxyvitamin D3 That Resist Metabolism through the C-24 Oxidation Pathway Are Metabolized through the C-3 Epimerization Pathway

  2000cites this paper
• Effects of long-term administration of vitamin D3 analogs to mice.

  2000cites this paper
• Biological activity of CD-ring modified 1alpha,25-dihydroxyvitamin D analogues: C-ring and five-membered D-ring analogues.

  2000cites this paper
• Vitamin D analogs, 20-Epi-22-oxa-24a,26a,27a,-trihomo-1alpha,25(OH)2-vitamin D3, 1,24(OH)2-22-ene-24-cyclopropyl-vitamin D3 and 1alpha,25(OH)2-lumisterol3 prime NB4 leukemia cells for monocytic differentiation via nongenomic signaling pathways, involving calcium and calpain.

  1999cites this paper
• 6-trans-16-ene-Vitamin D 3 : A New Class of Potent Inhibitors of Proliferation of Prostate , Breast , and Myeloid Leukemic Cells 1

  1999cites this paper
• Combination therapy of a vitamin D3 analog and all-trans-retinoic acid: effect on human breast cancer in nude mice.

  1999cites this paper
• Vitamin D Analogs, 20-Epi-22-Oxa-24a,26a,27a,-Trihomo-1α,25(OH)2-Vitamin D3, 1,24(OH)2-22-Ene-24-Cyclopropyl-Vitamin D3 and 1α,25(OH)2-Lumisterol3 Prime NB4 Leukemia Cells for Monocytic Differentiation via Nongenomic Signaling Pathways, Involving Calcium and Calpain1.

  1999cites this paper
• 20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines.

  1999cites this paper
• Differential Effects of 20‐Epi Vitamin D Analogs on the Vitamin D Receptor Homodimer

  1999cites this paper
• Cells of Proliferation of Prostate , Breast , and Myeloid Leukemic : A New Class of Potent Inhibitors 3-16-ene-Vitamin D trans 5 , 6-Updated

  1999cites this paper
• Antineoplastic effect and toxicity of 1,25-dihydroxy-16-ene-23-yne-vitamin D3 in athymic mice with Y-79 human retinoblastoma tumors.

  1999cites this paper
• 5,6-trans-16-ene-vitamin D3: a new class of potent inhibitors of proliferation of prostate, breast, and myeloid leukemic cells.

  1999cites this paper
• Leukemia cell differentiation: cellular and molecular interactions of retinoids and vitamin D.

  1999cites this paper
• Leukemia Cells for Monocytic Differentiation via Nongenomic Signaling Pathways , Involving Calcium and Calpain *

  1999cites this paper
• Synergistic inhibition of prostate cancer cell lines by a 19- nor hexafluoride vitamin D3 analogue and anti-activator protein 1 retinoid

  1999cites this paper
• Expression of retinoic acid receptor-beta sensitizes prostate cancer cells to growth inhibition mediated by combinations of retinoids and a 19-nor hexafluoride vitamin D3 analog.

  1998cites this paper
• Growth inhibitory effects of 1,25-dihydroxyvitamin D3 and its synthetic analogue, 1alpha,25-dihydroxy-16-ene-23yne-26,27-hexafluoro-19-nor-cholecalcifero l (Ro 25-6760), on a human colon cancer xenograft.

  1998cites this paper
• Toxicity and dose-response studies of 1,25-(OH)2-16-ene-23-yne vitamin D3 in transgenic mice.

  1998cites this paper
• Growth inhibition and differentiation induction in human monoblastic leukaemia cells by 1alpha-hydroxyvitamin D derivatives and their enhancement by combination with hydroxyurea.

  1998cites this paper
• Vitamin D3 and Retinoid-Mediated Inhibition of Leukemic Cells

  1998cites this paper
• 19-nor-26,27-bishomo-vitamin D3 analogs: a unique class of potent inhibitors of proliferation of prostate, breast, and hematopoietic cancer cells.

  1998cites this paper
• Induction of the differentiation of HL-60 promyelocytic leukemia cells by nonsteroidal anti-inflammatory agents in combination with low levels of vitamin D3.

  1998cites this paper
• Expression of Retinoic Acid Receptor-β Sensitizes Prostate Cancer Cells to Growth Inhibition Mediated by Combinations of Retinoids and a 19-nor Hexafluoride Vitamin D3 Analog.

  1998cites this paper
• A novel uracil analog, 6-chloro-5-(2-propenyl)uracil, preferentially enhances growth inhibition and differentiation of myeloid leukemia cells induced by 1alpha,25-dihydroxyvitamin D3.

  1998cites this paper
• 19-nor-hexafluoride analogue of vitamin D3: a novel class of potent inhibitors of proliferation of human breast cell lines.

  1997cites this paper
• Effects of potent vitamin D3 analogs on clonal proliferation of human prostate cancer cell lines

  1997cites this paper
• Three synthetic vitamin D analogues induce prostate-specific acid phosphatase and prostate-specific antigen while inhibiting the growth of human prostate cancer cells in a vitamin D receptor-dependent fashion.

  1997cites this paper
• Proliferation and differentiation of cultured human keratinocytes is modulated by 1,25(OH)2D3 and synthetic vitamin D3 analogues in a cell density-, calcium- and serum-dependent manner.

  1997cites this paper
• Integrity of the 1,25‐dihydroxyvitamin D3 receptor in bone, lung, and other cancers

  1997cites this paper
• CB1093, a novel vitamin D analog; effects on differentiation and clonal growth on HL-60 and de novo leukemia cells.

  1997cites this paper
• Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin.

  1997cites this paper
• Induction of the differentiation of HL-60 promyelocytic leukemia cells by curcumin in combination with low levels of vitamin D3.

  1997cites this paper
• Induction of the differentiation of HL-60 promyelocytic leukemia cells by vitamin E and other antioxidants in combination with low levels of vitamin D3: possible relationship to NF-κB

  1997cites this paper
• Toward therapeutic intervention of cancer by vitamin D compounds.

  1997cites this paper
• The role of vitamin D derivatives and retinoids in the differentiation of human leukaemia cells.

  1997cites this paper
• Ethacrynic acid and 1 alpha,25-dihydroxyvitamin D3 cooperatively inhibit proliferation and induce differentiation of human myeloid leukemia cells.

  1996cites this paper
• Differentiation therapy in myelodysplastic syndromes.

  1996cites this paper
• A new series of vitamin D analogs is highly active for clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia.

  1996cites this paper
• Induction of Differentiation and Production of Cytokines of HL-60 Cells by 22-Oxa-1α, 25-Dihydroxyvitamin D 3

  1996cites this paper
• Vitamin D3 analogs inhibit growth and induce differentiation in LA-N-5 human neuroblastoma cells

  1996cites this paper
• 20-Epi-vitamin D3 analogs. Potent modulators of proliferation and differentiation of breast cancer cell lines in vitro.

  1996cites this paper
• Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone.

  1996cites this paper
• 20-epi-vitamin D3 analogues: a novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines.

  1995cites this paper
• Potent vitamin D3 analogs: their abilities to enhance transactivation and to bind to the vitamin D3 response element.

  1995cites this paper
• and Inducers of Differentiation of Human Breast Cancer Cell Lines

  1995cites this paper