Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature Cell Biology

• Publication date

  2007-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/ncb1641PMID 17891137
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.

  2006cited by this paper
• Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase

  2006cited by this paper
• Merlin facilitates ubiquitination and degradation of transactivation-responsive RNA-binding protein

  2006cited by this paper
• Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

  2006cited by this paper
• Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.

  2006cited by this paper
• Nuclear Akt associates with PKC‐phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase‐activated DNase

  2006cited by this paper
• Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

  2005cited by this paper
• Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation

  2005cited by this paper
• Cyclic AMP-dependent Protein Kinase Phosphorylates Merlin at Serine 518 Independently of p21-activated Kinase and Promotes Merlin-Ezrin Heterodimerization*

  2004cited by this paper
• Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression

  2004cited by this paper
• Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L

  2004cited by this paper
• Merlin Neutralizes the Inhibitory Effect of Mdm2 on p53*

  2004cited by this paper
• Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor.

  2003cited by this paper
• Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization*

  2002cited by this paper
• PKB binding proteins. Getting in on the Akt.

  2002cited by this paper
• p21-activated Kinase Links Rac/Cdc42 Signaling to Merlin*

  2002cited by this paper
• Mutant Products of the NF2 Tumor Suppressor Gene Are Degraded by the Ubiquitin-Proteasome Pathway*

  2002cited by this paper
• Erythrocyte spectrin is an E2 ubiquitin conjugating enzyme.

  2001cited by this paper
• A novel isoform of beta-spectrin II localizes to cerebellar Purkinje-cell bodies and interacts with neurofibromatosis type 2 gene product schwannomin

  2001cited by this paper
• HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

  2001cited by this paper
• Binding of the merlin-I product of the neurofibromatosis type 2 tumour suppressor gene to a novel site in beta-fodrin is regulated by association between merlin domains.

  2001cited by this paper
• The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44.

  2001cited by this paper
• Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain.

  2000cited by this paper
• Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin

  2000influential reference
• Neurofibromatosis 2 tumor suppressor protein, merlin, forms two functionally important intramolecular associations

  1999cited by this paper
• Interdomain Interaction of Merlin Isoforms and Its Influence on Intermolecular Binding to NHE-RF*

  1999cited by this paper
• Neurofibromatosis 2 tumour suppressor schwannomin interacts with βII-spectrin

  1998cited by this paper
• Regulation of the Neurofibromatosis Type 2 Tumor Suppressor Protein, Merlin, by Adhesion and Growth Arrest Stimuli*

  1998cited by this paper

• Nf2/FGFR1/AKT axis directs cranial neural crest–derived skull morphogenesis via collagen synthesis and trafficking

  2025influential citation
• The molecular biology of NF2/Merlin on tumorigenesis and development

  2024cites this paper
• MARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human Cancer

  2024cites this paper
• The genetic landscape and possible therapeutics of neurofibromatosis type 2

  2023cites this paper
• CD44 Intracellular Domain: A Long Tale of a Short Tail

  2023cites this paper
• Hepatitis C virus nonstructural protein 4B induces lipogenesis via the Hippo pathway

  2023cites this paper
• RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11

  2022cites this paper
• Novel patient‐derived xenograft and cell line models for therapeutic screening in NF2‐associated schwannoma

  2022cites this paper
• Self-Sustained Regulation or Self-Perpetuating Dysregulation: ROS-dependent HIF-YAP-Notch Signaling as a Double-Edged Sword on Stem Cell Physiology and Tumorigenesis

  2022cites this paper
• TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.

  2021cites this paper
• Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity.

  2021cites this paper
• Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non-small cell lung cancer

  2021cites this paper
• RPRM negatively regulates ATM levels involving its phosphorylation mediated by CDK4/CDK6

  2021cites this paper
• CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation

  2021cites this paper
• IL‐37‐induced activation of glycogen synthase kinase 3β promotes IL‐1R8/Sigirr phosphorylation, internalization, and degradation in lung epithelial cells

  2021cites this paper
• NEDD4L‐mediated Merlin ubiquitination facilitates Hippo pathway activation

  2020cites this paper
• Tumor Necrosis Factor-Induced miR-146a Upregulation Promotes Human Lung Adenocarcinoma Metastasis by Targeting Merlin

  2020cites this paper
• Hepatitis C Virus nonstructural protein 4B induces lipogenesis via Merlin-Hippo pathway

  2020cites this paper
• Revisión: Mecanismos moleculares de la neurofibromatosis tipo 2

  2020cites this paper
• TARBP2-Enhanced Resistance during Tamoxifen Treatment in Breast Cancer

  2019cites this paper
• Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition

  2019cites this paper
• ILK/AKT Signaling Regulates miR-21 Expression in Vestibular Schwannoma and Meningioma

  2018cites this paper
• Standard CD44 modulates YAP1 through a positive feedback loop in hepatocellular carcinoma.

  2018cites this paper
• The potential of CRL4-DCAF1 and KSR1 as therapeutic targets in low-grade Merlin-deficient tumours

  2018cites this paper
• Synergistic effect of Nutlin-3 combined with MG-132 on schwannoma cells through restoration of merlin and p53 tumour suppressors

  2018cites this paper
• NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma

  2018cites this paper
• A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair

  2017cites this paper
• AWARD NUMBER: W81XWH-14-1-0096 TITLE: Contribution of p75 to schwannoma growth and therapeutic responses PRINCIPAL INVESTIGATOR:

  2016cites this paper
• The Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway Activation.

  2016cites this paper
• NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart.

  2016cites this paper
• Molecular profiling reveals primary mesothelioma cell lines recapitulate human disease

  2016cites this paper
• NF 2 is a “ gatekeeper ” during tissue repair normal tissue repair cell-cell contact stimulation of repair in NF 2 signaling deficient cell

  2016cites this paper
• Molecular Genetics of Meningioma

  2016cites this paper
• The combination of sorafenib and everolimus shows antitumor activity in preclinical models of malignant pleural mesothelioma

  2015cites this paper
• Regulation of Cell Adhesion by the FERM Proteins, PTPN14 and Merlin

  2015cites this paper
• Merlin negative regulation by miR-146a promotes cell transformation.

  2015cites this paper
• Germline and somatic mutations in meningiomas.

  2015cites this paper
• Chapter 2 Merlin and Angiomotin in Hippo-Yap Signaling

  2015cites this paper
• Merlin status regulates p75(NTR) expression and apoptotic signaling in Schwann cells following nerve injury.

  2015cites this paper
• Role of Merlin/NF2 Inactivation in Tumor Biology

  2015cites this paper
• Merlin sumoylation is required for its tumor suppressor activity

  2014cites this paper
• Hippo/YAP pathway for targeted therapy.

  2014cites this paper
• Oncogenic Role of Merlin/NF2 in Glioblastoma

  2014cites this paper
• Molecular conformation of the full-length tumor suppressor NF2/Merlin--a small-angle neutron scattering study.

  2014cites this paper
• Molecular insights into NF2/Merlin tumor suppressor function

  2014cites this paper
• SCF E3 ligase F‐box protein complex SCFFBXL19 regulates cell migration by mediating Rac1 ubiquitination and degradation

  2013cites this paper
• Merlin and Angiomotin in Hippo-Yap Signaling

  2013cites this paper
• CD43 Promotes Cells Transformation by Preventing Merlin-Mediated Contact Inhibition of Growth

  2013cites this paper
• Neurofibromatosis type 2 protein, NF2: an uncoventional cell cycle regulator.

  2013cites this paper
• regulates cell migration by mediating Rac1 ubiquitination and degradation

  2013cites this paper
• Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity

  2012cites this paper
• Merlin Is a Negative Regulator of Human Melanoma Growth

  2012cites this paper
• Epidermal Growth Factor Promotes Protein Degradation of Epithelial Protein Lost in Neoplasm (EPLIN), a Putative Metastasis Suppressor, during Epithelial-mesenchymal Transition*

  2012cites this paper
• Hippo Pathway Phylogenetics Predicts Monoubiquitylation of Salvador and Merlin/Nf2

  2012cites this paper
• Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus

  2012cites this paper
• Merlin: the wizard requires protein stability to function as a tumor suppressor.

  2012cites this paper
• Characterization of phosphorylation-dependent interactions involving neurofibromin 2 (NF2, merlin) isoforms and the Parkinson protein 7 (PARK7, DJ1)

  2012cites this paper
• Review: The molecular mechanisms of neurofibromatosis type 2

  2012cites this paper
• I, Timmy Mani , hereby submit this original work as part of the requirements for the degree of Doctor of Philosophy in Cell & Molecular Biology.

  2011cites this paper
• AKT1 (v-akt murine thymoma viral oncogene homolog 1)

  2011cites this paper
• Functional Regulation of the Neurofibromatosis 2 Tumor Suppressor Merlin

  2011cites this paper
• Mixed lineage kinase 3 signaling in ovarian cancer and neurofibromatosis-2

  2011cites this paper
• The role of phosphoinositide binding in merlin function

  2011cites this paper
• Asbestos-induced tissue regeneration and malignant pleural mesothelioma: Insights from developmental studies

  2011cites this paper
• Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation

  2011cites this paper
• Loss of Tumor Suppressor Merlin in Advanced Breast Cancer Is due to Post-translational Regulation*

  2011cites this paper
• Akt isoform-specific signaling in breast cancer

  2011cites this paper
• Frontier of Epilepsy Research - mTOR signaling pathway

  2011cites this paper
• Combining Curcumin (Diferuloylmethane) and Heat Shock Protein Inhibition for Neurofibromatosis 2 Treatment: Analysis of Response and Resistance Pathways

  2011influential citation
• Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin.

  2011influential citation
• FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function

  2011influential citation
• Bimodal regulation of FoxO3 by AKT and 14-3-3.

  2011cites this paper
• ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration.

  2011cites this paper
• Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.

  2010cites this paper
• Regulatory and functional aspects of Foxo3a transcription factor and their implications in prostate cancer

  2010cites this paper
• NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation

  2010influential citation
• Mesothelioma.

  2010cites this paper
• Id1 enhances RING1b E3 ubiquitin ligase activity through the Mel-18/Bmi-1 polycomb group complex

  2010cites this paper
• Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.

  2010cites this paper
• CHAPTER 8 – Molecular Biology and Genetics of Meningiomas

  2010cites this paper
• Akt Phosphorylation and PI (3, 4, 5) P3 Binding Coordinately Inhibit the Tumor Suppressive Activity of Merlin

  2010cites this paper
• Merlin/NF2 Tumor Suppressor and Ezrin–Radixin–Moesin (ERM) Proteins in Cancer Development and Progression

  2010cites this paper
• CD44 Meets Merlin and Ezrin: Their Interplay Mediates the Pro-Tumor Activity of CD44 and Tumor-Suppressing Effect of Merlin

  2009cites this paper
• Functional inactivation of NF2/merlin in human mesothelioma.

  2009cites this paper
• Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.

  2009cites this paper
• Akt phosphorylation of merlin enhances its binding to phosphatidylinositols and inhibits the tumor-suppressive activities of merlin.

  2009cites this paper
• Malignant pleural mesothelioma.

  2009cites this paper
• Hereditary tumor syndromes and gliomas.

  2009cites this paper
• The Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Transforming Growth Factor-β Signaling by Destabilizing Ski and Inducing Smad7*

  2009cites this paper
• Merlin is a potent inhibitor of glioma growth.

  2008cites this paper
• Protein kinase A-mediated phosphorylation of the NF2 tumor suppressor protein merlin at serine 10 affects the actin cytoskeleton

  2008cites this paper
• Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.

  2008cites this paper
• Mechanisms Promoting Phosphorylation Of The Nf2 Tumor Suppressor And Its Effects On Schwann Cell Development

  2007cites this paper
• Phosphorylation of Merlin Regulates its Stability and Tumor Suppressive Activity

  2007cites this paper