Characterization and Quantification of Isoflurane-Induced Developmental Apoptotic Cell Death in Mouse Cerebral Cortex

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Anesthesia and Analgesia

• Publication date

  2013-03-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1213/ANE.0b013e318281e988PMID 23460572
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neurodevelopmental outcome following exposure to sedative and analgesic drugs for complex cardiac surgery in infancy *

  2011cited by this paper
• Isoflurane Neurotoxicity Is Mediated by p75NTR-RhoA Activation and Actin Depolymerization

  2011cited by this paper
• Astrocytes are GABAergic cells that modulate microglial activity

  2011cited by this paper
• Comparison of the Neuroapoptotic Properties of Equipotent Anesthetic Concentrations of Desflurane, Isoflurane, or Sevoflurane in Neonatal Mice

  2011cited by this paper
• Early Childhood Exposure to Anesthesia and Risk of Developmental and Behavioral Disorders in a Sibling Birth Cohort

  2011cited by this paper
• The glutaminergic, GABAergic, dopaminergic but not cholinergic neurons are susceptible to anaesthesia-induced cell death in the rat developing brain.

  2011cited by this paper
• Isoflurane-induced Neuroapoptosis in the Neonatal Rhesus Macaque Brain

  2010cited by this paper
• Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters

  2010cited by this paper
• Role of the Proteasome in Excitotoxicity-Induced Cleavage of Glutamic Acid Decarboxylase in Cultured Hippocampal Neurons

  2010cited by this paper
• Timing versus duration

  2010cited by this paper
• Developmental neurotoxicity of sedatives and anesthetics: A concern for neonatal and pediatric critical care medicine?*

  2010cited by this paper
• A novel mechanism for GABA synthesis and packaging into synaptic vesicles.

  2009cited by this paper
• Anesthesia and Cognitive Performance in Children: No Evidence for a Causal Relationship

  2009cited by this paper
• The Effects of Neonatal Isoflurane Exposure in Mice on Brain Cell Viability, Adult Behavior, Learning, and Memory

  2009cited by this paper
• Inhibition of p75 Neurotrophin Receptor Attenuates Isoflurane-mediated Neuronal Apoptosis in the Neonatal Central Nervous System

  2009cited by this paper
• Isoflurane Inhibits Growth but Does Not Cause Cell Death in Hippocampal Neural Precursor Cells Grown in Culture

  2009cited by this paper
• Isoflurane Differentially Affects Neurogenesis and Long-term Neurocognitive Function in 60-day-old and 7-day-old Rats

  2009cited by this paper
• Early Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort

  2009cited by this paper
• Effect of Hypercarbia and Isoflurane on Brain Cell Death and Neurocognitive Dysfunction in 7-day-old Rats

  2009cited by this paper
• Pro: Anesthesia-induced Developmental Neuroapoptosis: Status of the Evidence

  2008cited by this paper
• GABAA receptors, anesthetics and anticonvulsants in brain development.

  2008cited by this paper
• Isoflurane-induced Neuroapoptosis in the Developing Brain of Nonhypoglycemic Mice

  2008cited by this paper
• Neuron-Astrocyte Signaling in the Development and Plasticity of Neural Circuits

  2008cited by this paper
• Prolonged sedation and/or analgesia and 5-year neurodevelopment outcome in very preterm infants: results from the EPIPAGE cohort.

  2008cited by this paper
• Con: The Toxic Effects of Anesthetics in the Developing Brain: the Clinical Perspective

  2008cited by this paper
• National Hospital Discharge Survey: 2005 annual summary with detailed diagnosis and procedure data.

  2007cited by this paper
• Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity.

  2007cited by this paper
• Unbiased cell quantification reveals a continued increase in the number of neocortical neurones during early post‐natal development in mice

  2007cited by this paper
• Xenon Mitigates Isoflurane-induced Neuronal Apoptosis in the Developing Rodent Brain

  2007cited by this paper
• Insulin‐like growth factor‐I (IGF‐I) inhibits neuronal apoptosis in the developing cerebral cortex in vivo

  2007cited by this paper
• Cortical neurogenesis enhanced by chronic perinatal hypoxia.

  2006cited by this paper
• Isoflurane and sevoflurane affect cell survival and BCL-2/BAX ratio differently.

  2005cited by this paper
• Isoflurane-Induced Neuronal Degeneration: An Evaluation in Organotypic Hippocampal Slice Cultures

  2005cited by this paper
• Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways.

  2005cited by this paper
• Confidence limits for the ratio of two rates based on likelihood scores: non‐iterative method

  2003cited by this paper
• Visualization of S100B‐positive neurons and glia in the central nervous system of EGFP transgenic mice

  2003cited by this paper
• Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits

  2003cited by this paper
• Astrocytes and Stroke: Networking for Survival?

  2003cited by this paper
• Confidence limits for the ratio of two rates based on likelihood scores: non‐iterative method. P. L. Graham, K. Mengersen and A. P. Morton, Statistics in Medicine, 2003; 22:2071–2083

  2003cited by this paper
• The mouse brain in stereotaxic coordinates

  2003cited by this paper
• Astrocyte Modulation of Neurotoxic Injury

  2002cited by this paper
• Ischemia‐induced apoptosis in primary cultures of astrocytes

  2001cited by this paper
• Translating developmental time across mammalian species.

  2001cited by this paper
• Programmed cell death in the developing human telencephalon

  2000cited by this paper
• Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias.

  1999cited by this paper
• Muscimol-induced death of GABAergic neurons in rat brain aggregating cell cultures.

  1998cited by this paper
• Presence of S-100 beta in cholinergic neurones of the rat hindbrain.

  1996cited by this paper
• Selective toxicity of the general anesthetic propofol for GABAergic neurons in rat brain cell cultures

  1996cited by this paper
• Presence of S‐100β in cholinergic neurones of the rat hindbrain

  1996cited by this paper
• Numerical data on neocortical neurons in adult rat, with special reference to the GABA population.

  1993cited by this paper
• NeuN, a neuronal specific nuclear protein in vertebrates.

  1992cited by this paper
• Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

  1991cited by this paper
• The structural and functional heterogeneity of glutamic acid decarboxylase: A review

  1991cited by this paper
• Cell death during development of the nervous system.

  1991cited by this paper
• Quantitative growth and development of human brain

  1973cited by this paper
• Mode of cell migration to the superficial layers of fetal monkey neocortex

  1972cited by this paper

• Effects of Repeated Early-life Anesthesia Exposure on Visual System Development in Mice

  2025cites this paper
• Association between general anaesthesia exposure and neurodevelopment in children with congenital scoliosis at a Chinese tertiary hospital: study protocol for a prospective longitudinal observational cohort study

  2025cites this paper
• Neonatal sevoflurane exposure enhances stress-related neurological susceptibility via NKCC1 modulation

  2025cites this paper
• Pain and anesthesia — on fetal nervous system and brain development

  2025cites this paper
• Ongoing loss of viable neurons for weeks after mild hypoxia-ischaemia

  2025cites this paper
• THE EFFECT OF N- ACETYLCYSTEINE ON THE NEUROTOXICITY OF SEVOFLURANE IN DEVELOPING HIPPOCAMPUS CELLS.

  2024cites this paper
• Repeated postnatal sevoflurane exposure impairs social recognition in mice by disrupting GABAergic neuronal activity and development in hippocampus.

  2024cites this paper
• Early Findings of a Preterm Twin Cohort Study Examining the Effect of General Anesthesia on Developmental Outcomes

  2024cites this paper
• Clinical and environmental considerations for neonatal, office-based circumcisions compared with operative circumcisions

  2024cites this paper
• Zona incerta mediates early life isoflurane-induced fear memory deficits

  2024cites this paper
• Effects of general anaesthesia in early childhood on local and global visual processing: a post hoc analysis of the APEX cohort study.

  2024cites this paper
• Pediatric regional anesthesiology: a narrative review and update on outcome-based advances.

  2023cites this paper
• The bibliometric analysis of most cited 100 papers in anesthesia-induced neurotoxicity

  2023cites this paper
• Regional Anesthesia for Neonates.

  2023cites this paper
• Review of Spinal Anesthesia for Pediatric Genitourinary Surgery

  2023cites this paper
• Whole-brain characterization of apoptosis after sevoflurane anesthesia reveals neuronal cell death patterns in the mouse neonatal neocortex

  2023cites this paper
• The impact of early exposure to general anesthesia on visual and neurocognitive development.

  2022cites this paper
• Acutely increased aquaporin-4 exhibits more potent protective effects in the cortex against single and repeated isoflurane-induced neurotoxicity in the developing rat brain

  2022influential citation
• Application of Nonhuman Primate Models in the Studies of Pediatric Anesthesia Neurotoxicity.

  2022cites this paper
• Effects of Pregnancy Anesthesia on Fetal Nervous System

  2021cites this paper
• GABAergic neurons are susceptible to BAX-dependent apoptosis following isoflurane exposure in the neonatal period

  2021cites this paper
• Local Anesthetic Injection Before Incision Decreases General Anesthesia Requirements in Pediatric Trigger Thumb Release: A Randomized Controlled Trial

  2021cites this paper
• Early Development of the GABAergic System and the Associated Risks of Neonatal Anesthesia

  2021influential citation
• The Contribution of Dysfunctional Chloride Channels to Neurovascular Deficiency and Neurodegeneration

  2021cites this paper
• Longitudinal impact on rat cardiac tissue transcriptomic profiles due to acute intratracheal inhalation exposures to isoflurane

  2021cites this paper
• Prenatal sevoflurane exposure causes abnormal development of the entorhinal cortex in rat offspring.

  2021cites this paper
• The potential role of dexmedetomidine on neuroprotection and its possible mechanisms: Evidence from in vitro and in vivo studies

  2021cites this paper
• Normal Development of Local Neurovascular Interactions and the Diagnostic Value of Resting State Functional MRI in Neurovascular Deficiency Based on the Example of Neonatal Anesthesia Exposure

  2021cites this paper
• Hypoxia, hypercarbia, and mortality reporting in studies of anaesthesia-related neonatal neurodevelopmental delay in rodent models: A systematic review.

  2020cites this paper
• Sevoflurane-Induced Neuroapoptosis in Rat Dentate Gyrus Is Activated by Autophagy Through NF-κB Signaling on the Late-Stage Progenitor Granule Cells

  2020cites this paper
• BAX is necessary for neuronal death following exposure to isoflurane during the neonatal period

  2020cites this paper
• Attention deficit hyperactivity disorder and educational level in adolescent and adult individuals after anesthesia and abdominal surgery during infancy

  2020cites this paper
• An appropriate level of autophagy reduces emulsified isoflurane-induced apoptosis in fetal neural stem cells

  2020cites this paper
• Impact of anesthesia exposure in early development on learning and sensory functions.

  2020cites this paper
• Thoracoscopic Repair of Congenital Diaphragmatic Hernia

  2020cites this paper
• Expression and functions of KCC2 in the perinatal rodent cortex

  2020influential citation
• Anesthesia affects excitatory/inhibitory synapses during the critical synaptogenic period in the hippocampus of young mice: Importance of sex as a biological variable

  2019cites this paper
• Anesthesia Neurotoxicity in the Developing Brain: Basic Studies Relevant for Neonatal or Perinatal Medicine.

  2019cites this paper
• Nonexperimental Xenobiotics: Unintended Consequences of Intentionally Administered Substances in Terrestrial Animal Models.

  2019cites this paper
• Early Developmental Exposure to Repetitive Long Duration of Midazolam Sedation Causes Behavioral and Synaptic Alterations in a Rodent Model of Neurodevelopment

  2019cites this paper
• Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial.

  2019cites this paper
• Surgery, Anesthesia, and the Immature Brain

  2019cites this paper
• Physiologic Changes in a Small Animal Model for Neonatal Minimally Invasive Surgery

  2018cites this paper
• Spinal anaesthetic approach : anatomical and physiological differences in paediatric patients

  2018cites this paper
• Nitrogen narcosis induced by repetitive hyperbaric nitrogen oxygen mixture exposure impairs long-term cognitive function in newborn mice

  2018cites this paper
• Intravenous anesthetic‐induced calcium dysregulation and neurotoxic shift with age during development in primary cultured neurons

  2018cites this paper
• Astragaloside suppresses tumor necrosis factor receptor‐associated factor 5 signaling pathway and alleviates neurodegenerative changes in retinal pigment epithelial cells induced by isoflurane

  2018cites this paper
• Dexmedetomidine-mediated neuroprotection against sevoflurane-induced neurotoxicity extends to several brain regions in neonatal rats

  2017cites this paper
• Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach

  2017cites this paper
• More than 3 hours and less than 3 years old. Safety of anesthetic procedures in children under 3 years of age, subject to surgeries of more than 3 hours.

  2017cites this paper
• Effect of Anesthesia on the Developing Brain: Infant and Fetus

  2017cites this paper
• Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies.

  2017cites this paper
• Isoflurane but not Fentanyl Causes Apoptosis in Immature Primary Neuronal Cells

  2017cites this paper
• More than 3 hours and less than 3 years old. Safety of anesthetic procedures in children under 3 years of age, subject to surgeries of more than 3 hours.

  2017cites this paper
• Surgery increases cell death and induces changes in gene expression compared with anesthesia alone in the developing piglet brain

  2017cites this paper
• Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway

  2017cites this paper
• Neuroanesthesiology Update

  2017cites this paper
• Spinal Anaesthetic Management in Paediatric Surgery

  2017cites this paper
• Lasting impact of general anaesthesia on the brain: mechanisms and relevance

  2016cites this paper
• Biomarkers, Genetics, and Epigenetic Studies to Explore the Neurocognitive Effects of Anesthesia in Children

  2016cites this paper
• Neuroprotective effects of caffeic acid phenethyl ester against sevoflurane‑induced neuronal degeneration in the hippocampus of neonatal rats involve MAPK and PI3K/Akt signaling pathways.

  2016cites this paper
• Anaesthesia in early childhood - is the development of the immature brain in danger?

  2016cites this paper
• Etomidate exposure in early infant mice (P10) does not induce apoptosis or affect behaviour

  2016cites this paper
• Anesthetic depth and long-term survival: an update

  2016cites this paper
• Intravenous induction of anaesthesia in children : aspects on propofol and etomidate

  2016cites this paper
• Inhalational agents in anesthesia induced developmental neurotoxicity – Recent advances

  2016cites this paper
• A systematic review of methodology applied during preclinical anesthetic neurotoxicity studies: important issues and lessons relevant to the design of future clinical research

  2016cites this paper
• Rationale and Design of the Balanced Anesthesia Study: A Prospective Randomized Clinical Trial of Two Levels of Anesthetic Depth on Patient Outcome After Major Surgery

  2015cites this paper
• Efficacy of rutin in inhibiting neuronal apoptosis and cognitive disturbances in sevoflurane or propofol exposed neonatal mice.

  2015cites this paper
• Neurodevelopmental implications of the general anesthesia in neonate and infants.

  2015cites this paper
• Is this your (paediatric patient's) brain on (anaesthetic) drugs?: The search for a potential neurological phenotype of anaesthesia-related neurotoxicity in humans.

  2015cites this paper
• Neurodevelopmental outcome at two years of age after general and awake-regional anaesthesia in infancy: a randomised controlled trial

  2015cites this paper
• Developmental stage‐dependent impact of midazolam on calbindin, calretinin and parvalbumin expression in the immature rat medial prefrontal cortex during the brain growth spurt

  2015cites this paper
• Factors That Can Influence Animal Research

  2015cites this paper
• Anesthesia-Induced Neuronal Apoptosis in the Developing Retina: A Window of Opportunity

  2015cites this paper
• Systemic physiology and neuroapoptotic profiles in young and adult rats exposed to surgery: A randomized controlled study comprising four different anaesthetic techniques

  2015cites this paper
• S6 inhibition contributes to isoflurane neurotoxicity in the developing brain.

  2015cites this paper
• Increased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia

  2015cites this paper
• Isoflurane Damages the Developing Brain of Mice and Induces Subsequent Learning and Memory Deficits through FASL-FAS Signaling

  2015cites this paper
• Anaesthetics-Induced Neurotoxicity in Developing Brain: An Update on Preclinical Evidence

  2014cites this paper
• Comparison of Neurodegeneration and Cognitive Impairment in Neonatal Mice Exposed to Propofol or Isoflurane

  2014cites this paper
• Die Wirkungsweise der TRPV1-Kanäle auf die synaptische Plastizität im lateralen Kern der Amygdala

  2014cites this paper
• Neonatal ketamine exposure causes impairment of long-term synaptic plasticity in the anterior cingulate cortex of rats.

  2014cites this paper
• Neuroanesthesiology Update

  2014cites this paper
• Impact of levosimendan on brain injury patterns in a lamb model of infant cardiopulmonary bypass

  2014cites this paper
• Toxic and protective effects of inhaled anaesthetics on the developing animal brain: Systematic review and update of recent experimental work

  2014cites this paper
• Brain regional vulnerability to anaesthesia-induced neuroapoptosis shifts with age at exposure and extends into adulthood for some regions.

  2014cites this paper
• Cell age–specific vulnerability of neurons to anesthetic toxicity

  2013cites this paper
• Real-time 3-dimensional transesophageal echocardiography: improvements in intraoperative mitral valve imaging.

  2013cites this paper
• Sevoflurane and its role in the development of chronic postsurgical pain: where is the smoking gun?

  2013cites this paper
• In response.

  2013cites this paper
• Does isoflurane or isoflurane plus hyperoxia induce apoptotic cell death?

  2013cites this paper
• Cancer prognosis: can anesthesia play a role?

  2013cites this paper
• Anesthesia for the young child undergoing ambulatory procedures: current concerns regarding harm to the developing brain

  2013cites this paper
• Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.

  2013cites this paper
• Isoflurane suppresses early cortical activity

  2013cites this paper
• Cancer Prognosis Can Anesthesia Play a Role?

  2013cites this paper
• Post-Surgery Cognitive Dysfunction Diagnostics in Children

  year unknowncites this paper