In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract

Trigonella foenum-graecum is one of the widely used herbs in food and medicine. The seeds of the plants are investigated for antidiabetic potential; however, no efforts have been done to explore the potential of leaves to modify carbohydrate metabolizing enzymes viz. α-amylase and α-glucosidase. The present work was designed to investigate the inhibitory potential of ethyl acetate and water extract of T. foenum-graecum on enzymes α-amylase and α-glucosidase. Different concentrations of extracts were used to study inhibition of enzymatic activity of α-amylase and α-glucosidase. A dose dependent inhibitory effect on enzymes was observed. The current study, for the first time, revealed α-amylase and α-glucosidase inhibitory potential of T. foenum-graecum and the study could be helpful to isolate and characterize compounds responsible for it.

• Publication year

  2013

• Venue

  Ayu

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.4103/0974-8520.115446PMID 24049415PMCID 3764866
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alfa-glucosidase-inhibiting activity of some Mexican plants used in the treatment of type 2 diabetes.

  2008cited by this paper
• Fenugreek (Trigonella foenum graecum) seed polyphenols protect liver from alcohol toxicity: a role on hepatic detoxification system and apoptosis.

  2007cited by this paper
• Alpha-glucosidase inhibitory and antioxidant activities of Vietnamese edible plants and their relationships with polyphenol contents.

  2007cited by this paper
• Modulatory Effect of Fenugreek Seed Mucilage and Spent Turmeric on Intestinal and Renal Disaccharidases in Streptozotocin Induced Diabetic Rats

  2005cited by this paper
• Anti-hyperglycemic activity of Commelina communis L.: inhibition of α-glucosidase

  2004cited by this paper
• Anti-hyperglycemic activity of Commelina communis L.: inhibition of alpha-glucosidase.

  2004cited by this paper
• Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity.

  2002cited by this paper
• Mechanism of action of a hypoglycemic principle isolated from fenugreek seeds.

  2002cited by this paper
• Anti-inflammatory and antipyretic effects of Trigonella foenum-graecum leaves extract in the rat.

  2001cited by this paper
• Effects of chronic treatment with acarbose on glucose and lipid metabolism in obese diabetic Wistar rats

  2001cited by this paper
• α-Amylase Inhibitors from Roselle (Hibiscus sabdariffa Linn.) Tea

  2000cited by this paper
• [Studies on flavonoids from Fenugreek (Trigonella foenumgraecum L.)].

  1998cited by this paper
• Medicinal foodstuffs. IV. Fenugreek seed. (1): structures of trigoneosides Ia, Ib, IIa, IIb, IIIa, and IIIb, new furostanol saponins from the seeds of Indian Trigonella foenum-graecum L.

  1997cited by this paper
• Effect of Trigonella foenum graecum (Fenugreek) on blood glucose in normal and diabetic rats.

  1995cited by this paper
• Long-term suppression of postprandial hyperglycaemia with acarbose retards the development of neuropathies in the BB/W-rat

  1992cited by this paper
• Effect of Trigonella foenum graceum on blood glucose levels in normal and alloxan-diabetic mice.

  1988cited by this paper
• Protein-rich food mixtures for feeding the young in Egypt 1. Formulation

  1981cited by this paper

• Molecular Docking and In Vitro Assessment of Gymnema sylvestre R. Br. and Trigonella foenum‐graecum L. Phytochemicals as Dual α‐Amylase and α‐Glucosidase Inhibitors

  2025cites this paper
• Exploring the Role of Phytochemical Classes in the Biological Activities of Fenugreek (Trigonella feonum graecum): A Comprehensive Analysis Based on Statistical Evaluation

  2025cites this paper
• Assessment of in vitro cytotoxicity, anti-Alzheimer, and antidiabetic properties of fenugreek, white mulberry, and nettle leaves

  2025cites this paper
• Persian Medicinal Plants as Antidiabetic Agents: Mechanisms and Evidence from Bench to Bedside.

  2025cites this paper
• The novel role of Periploca laevigata Aiton extracts as antidiabetic and anti-inflammatory functions in pancreatic Β cells exposed to hyperglycaemia

  2025cites this paper
• Extraction of diosgenin using different techniques from fenugreek seeds- A review.

  2024cites this paper
• Formulation and assessment of chickpea pulao using fenugreek seeds and Indian rennet to improve blood glycemic levels

  2024cites this paper
• The Role of Fenugreek in the Management of Type 2 Diabetes

  2024cites this paper
• The Other Side of the Perfect Cup: Coffee-Derived Non-Polyphenols and Their Roles in Mitigating Factors Affecting the Pathogenesis of Type 2 Diabetes

  2024cites this paper
• HPLC-DAD-MS Characterization, Antioxidant Activity, α-amylase Inhibition, Molecular Docking, and ADMET of Flavonoids from Fenugreek Seeds

  2023cites this paper
• Hypoglycemic and hypocholesterolemic properties of Fenugreek: A comprehensive assessment

  2023cites this paper
• In Vitro α-Amylase and α-Glucosidase Inhibiting Activities of the Alcoholic Leaf Extracts of Trigonella foenum-graecum

  2023cites this paper
• Análisis fitoquímico y evaluación antidiabética de los palmitos de Chamaedorea tepejilote

  2023cites this paper
• Comparative evaluation of antioxidant, antiglycation and α-glucosidase inhibitory potential of some indigenous medicinal Trigonella species

  2022cites this paper
• Characterization of Possible α-Glucosidase Inhibitors from Trigonella stellata Extract Using LC–MS and In Silico Molecular Docking

  2022cites this paper
• Comparative metabolomics analysis of bioactive constituents of the leaves of different Trigonella species: Correlation study to α-amylase and α-glycosidase inhibitory effects

  2022cites this paper
• Jamun (Syzygium cumini (L.) Skeels) seed bioactives and its biological activities: A review

  2022cites this paper
• Direct and Indirect Effect of Honey as a Functional Food Against Metabolic Syndrome and Its Skeletal Complications

  2021cites this paper
• Glucose-lowering potential of Guiera senegalensis roots in a diabetic rat model

  2020cites this paper
• Chemical profiling of secondary metabolites from Himatanthus drasticus (Mart.) Plumel latex with inhibitory action against the enzymes α-amylase and α-glucosidase: In vitro and in silico assays.

  2020cites this paper
• Traditional Herbal Products Used for the Management of Diabetes in Croatia: Linking Traditional Use With α-Glucosidase-Inhibitory Activity

  2019cites this paper
• Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening

  2019cites this paper
• TRIGONELLA FOENUM : A REVIEW OF HYPOGLYCEMIC ACTIVITY

  2019influential citation
• Inhibitory effect of C. esculenta on -Amylase and -glucosidase enzyme activity: A LIBS based study

  2019cites this paper
• Nutritional and health benefits of fenugreek: A short review

  2018cites this paper
• Antidiabetic Activity and Phytochemical Constituents of Syzygium cumini Seeds in Puducherry Region, South India

  2018cites this paper
• A Review on the Protective Effects of Honey against Metabolic Syndrome

  2018cites this paper
• Maltase Inhibitory Activity of Aqueous Extracts of Zingiber officinale Rosc. and Trigonella foenum-graecum Linn.

  2018cites this paper
• ANTIOXIDANT ACTIVITY AND A-AMYLASE INHIBITORY POTENTIAL OF ROSA CANINA L

  2017cites this paper
• An exopolysaccharide (EPS) from a Lactobacillus plantarum BR2 with potential benefits for making functional foods.

  2017cites this paper
• Antihyperglycemic Activity of Caralluma fimbriata: An In vitro Approach

  2017cites this paper
• In Vitro α-Amylase and α-Glucosidase Inhibition Activity of Tabing Abutilon indicum ( Linn 1836 ) Root Extracts

  2016cites this paper
• FENUGREEK : A TREASURE OF BIOACTIVE COMPOUNDS WITH PROMISING ANTIDIABETIC POTENTIAL

  2015cites this paper
• Anti-inflammatory activity and the effect of Trigonella foenum grecum on some biochemical parameters in experimental rats

  2014cites this paper
• International Synergistic Multi-Enzyme Inhibition by Sri Lankan Medicinal Plants: A Promising Strategy for Effective Diabetes Management - A

  year unknowncites this paper