Use of aerosol route to fabricate positively charged Au/Fe3O4 Janus nanoparticles as multifunctional nanoplatforms

Gold (Au)-decorated iron oxide (Fe3O4), Au/Fe3O4, Janus nanoparticles were fabricated via the continuous route for aerosol Au incorporation with Fe3O4 domains synthesized in an aqueous medium as multifunctional nanoplatforms. The fabricated nanoparticles were subsequently exposed to 185-nm UV light to generate positive charges on Au surfaces, and their activities were tested in computed tomography (CT) and magnetic resonance (MR) imaging, gene-delivery and photothermal therapy. No additional polymeric coatings of the Janus particles also had a unique ability to suppress inflammatory responses in macrophages challenged with lipopolysaccharide, which may be due to the absence of amine groups.

• Publication year

  2016

• Venue

  Scientific Reports

• Publication date

  2016-10-07

• Fields of study

  Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.1038/srep35104PMID 27713519PMCID 5054399
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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