Platelet‐derived growth factor‐induced disruption of gap junctional communication and phosphorylation of connexin43 involves protein kinase C and mitogen‐activated protein kinase

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Cellular Physiology

• Publication date

  1998-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/(SICI)1097-4652(199808)176:2<332::AID-JCP11>3.0.CO;2-5PMID 9648920
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rapid disruption of gap junctional communication and phosphorylation of connexin43 by platelet‐derived growth factor in T51B rat liver epithelial cells expressing platelet‐derived growth factor receptor

  1998cited by this paper
• The activating dual phosphorylation of MAPK by MEK is nonprocessive.

  1997cited by this paper
• Mechanisms of inhibition by heparin of PDGF stimulated MAP kinase activation in vascular smooth muscle cells

  1997cited by this paper
• Loss of Gap Junction Plaques and Inhibition of Intercellular Communication in Ilimaquinone-treated BICR-M1Rk and NRK Cells

  1997cited by this paper
• Regulation of Mitogen-activated Protein Kinase Phosphatase-1 Expression by Extracellular Signal-related Kinase-dependent and Ca2+-dependent Signal Pathways in Rat-1 Cells*

  1997cited by this paper
• Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidylcholine-specific phospholipase C, protein kinase C-zeta and Raf-1.

  1997cited by this paper
• Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase

  1997cited by this paper
• Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

  1997cited by this paper
• Inhibition of PDGF-mediated proliferation of vascular smooth muscle cells by calcium antagonists.

  1997cited by this paper
• PKC phosphorylation disrupts gap junctional communication at G0/S phase in clone 9 cells

  1997cited by this paper
• Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase.

  1996cited by this paper
• Translocation of protein kinase C-delta by PDGF in cultured vascular smooth muscle cells: inhibition by TGF-beta 1.

  1996cited by this paper
• Connections with connexins: the molecular basis of direct intercellular signaling.

  1996cited by this paper
• PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta

  1996cited by this paper
• UV activates growth factor receptors via reactive oxygen intermediates

  1996cited by this paper
• Role of connexin genes in growth control.

  1996cited by this paper
• Regulation of platelet-derived growth factor isoform-mediated expression of prostaglandin G/H synthase in mesangial cells.

  1996cited by this paper
• Angiotensin II stimulates MAP kinase kinase kinase activity in vascular smooth muscle cells, Role of Raf.

  1996cited by this paper
• EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3‐kinase.

  1996cited by this paper
• Regulation of connexin43 function by activated tyrosine protein kinases

  1996cited by this paper
• Characterization of the Mitogen-activated Protein Kinase Phosphorylation Sites on the Connexin-43 Gap Junction Protein (*)

  1996cited by this paper
• Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor(*)

  1995cited by this paper
• Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions.

  1995cited by this paper
• Dimerization of cell surface receptors in signal transduction.

  1995cited by this paper
• Ductin – a proton pump component, a gap junction channel and a neurotransmitter release channel

  1995cited by this paper
• Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin (*)

  1995cited by this paper
• Use of selective tyrosine kinase blockers to monitor growth factor receptor dephosphorylation in intact cells.

  1995cited by this paper
• Protein Kinase C: Structure, Function, and Regulation (*)

  1995cited by this paper
• A synthetic inhibitor of the mitogen-activated protein kinase cascade.

  1995cited by this paper
• Mitogen-activated Protein (MAP) Kinase Is Regulated by the MAP Kinase Phosphatase (MKP-1) in Vascular Smooth Muscle Cells

  1995cited by this paper
• Participation of Acetylpseudouridine in the Synthesis of a Peptide Bond in Vitro(*)

  1995cited by this paper
• Utility of intensely fluorescent cyanine dyes (Cy3) for assay of gap junctional communication by dye-transfer.

  1995cited by this paper
• Inhibition of Glycosylation Induces Formation of Open Connexin-43 Cell-to-Cell Channels and Phosphorylation and Triton X-100 Insolubility of Connexin-43 (*)

  1995cited by this paper
• Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases.

  1995cited by this paper
• Activation of Mitogen-activated Protein Kinase by Arachidonic Acid in Rat Liver Epithelial WB Cells by a Protein Kinase C-dependent Mechanism (*)

  1995cited by this paper
• How MAP Kinases Are Regulated (*)

  1995cited by this paper
• Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C.

  1995cited by this paper
• Differential Activation of Mitogen-activated Protein Kinase and S6 Kinase Signaling Pathways by 12-O-Tetradecanoylphorbol-13-acetate (TPA) and Insulin

  1995cited by this paper
• Stimulation by endothelin‐1 of mitogen‐activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells

  1995cited by this paper
• Inhibition of gap junctional communication by polyunsaturated fatty acids in WB cells: evidence that connexin 43 is not hyperphosphorylated.

  1995cited by this paper
• Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.

  1994cited by this paper
• Platelet-derived growth factor receptor signals.

  1994cited by this paper
• Interferons block protein kinase C-dependent but not-independent activation of Raf-1 and mitogen-activated protein kinases and mitogenesis in NIH 3T3 cells

  1994cited by this paper
• Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element

  1994cited by this paper
• The tis genes, primary response genes induced by growth factors and tumor promoters in 3T3 cells.

  1994cited by this paper
• Activation of Na+/H+ exchange by platelet-derived growth factor involves phosphatidylinositol 3'-kinase and phospholipase C gamma.

  1994cited by this paper
• Dissociation of PDGF receptor tyrosine kinase activity from PDGF‐mediated inhibition of gap junctional communication

  1994cited by this paper
• p130gag-fps disrupts gap junctional communication and induces phosphorylation of connexin43 in a manner similar to that of pp60v-src.

  1994cited by this paper
• Preferential primary‐response gene expression in promotion‐resistant versus promotion‐sensitive JB6 cells

  1994cited by this paper
• Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters.

  1994cited by this paper
• Lysophosphatidic acid inhibits gap-junctional communication and stimulates phosphorylation of connexin-43 in WB cells: possible involvement of the mitogen-activated protein kinase cascade.

  1994cited by this paper
• Receptor protein-tyrosine kinases and their signal transduction pathways.

  1994cited by this paper
• Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor.

  1994cited by this paper
• Stimulation of the platelet-derived growth factor beta receptor signaling pathway activates protein kinase C-delta

  1994cited by this paper
• Changes in gap‐junction permeability, phosphorylation, and number mediated by phorbol ester and non‐phorbol‐ester tumor promoters in rat liver epithelial cells

  1994cited by this paper
• Phosphorylated Forms of Connexin43 Predominate in Rat Brain: Demonstration by Rapid Inactivation of Brain Metabolism

  1994cited by this paper
• p130gag-fps disrupts gap junctional communication and induces phosphorylation of connexin43 in a manner similar to that of pp60v-src.

  1994cited by this paper
• On the mechanisms of cell uncoupling induced by a tumor promoter phorbol ester in clone 9 cells, a rat liver epithelial cell line.

  1993cited by this paper
• Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

  1993cited by this paper
• Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

  1993cited by this paper
• Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase.

  1993cited by this paper
• Involvement of PKC-alpha in PDGF-mediated mitogenic signaling in human mesangial cells.

  1993cited by this paper
• Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases.

  1993cited by this paper
• Protein kinase C blocks somatostatin-induced modulation of calcium current in chick sympathetic neurons.

  1993cited by this paper
• Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of phosphatidylinositol 3-kinase activity as well as association of p85 subunit to tyrosine-phosphorylated PDGF receptor.

  1993cited by this paper
• Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase.

  1993cited by this paper
• Epidermal growth factor disrupts gap-junctional communication and induces phosphorylation of connexin43 on serine.

  1992cited by this paper
• Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

  1992cited by this paper
• Differential induction of 12‐O‐tetradecanoylphorbol‐13‐acetate sequence gene expression in murine melanocytes and melanoma cells

  1992cited by this paper
• The cell-cell channel in the control of growth.

  1992cited by this paper
• Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action.

  1991cited by this paper
• Transfection of C6 glioma cells with connexin 43 cDNA: analysis of expression, intercellular coupling, and cell proliferation.

  1991cited by this paper
• Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit.

  1991cited by this paper
• Evidence that heart connexin43 is a phosphoprotein.

  1991cited by this paper
• Phorbol ester induces phosphorylation and down-regulation of connexin 43 in WB cells.

  1991cited by this paper
• Involvement of gap junctions in tumorigenesis: transfection of tumor cells with connexin 32 cDNA retards growth in vivo.

  1991cited by this paper
• Gap junctional intercellular communication and carcinogenesis.

  1990cited by this paper
• Chemical, oncogene and growth factor inhibition gap junctional intercellular communication: an integrative hypothesis of carcinogenesis.

  1990cited by this paper
• Gap junctional communication and carcinogenesis

  1990cited by this paper
• Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts

  1990cited by this paper
• PDGF-induced activation of phospholipase C is not required for induction of DNA synthesis.

  1990cited by this paper
• Connexin family of gap junction proteins

  1990cited by this paper
• Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines

  1990cited by this paper
• Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins.

  1989cited by this paper
• Enhancement of gap junctional communication by retinoids correlates with their ability to inhibit neoplastic transformation.

  1989cited by this paper
• Growth inhibition of transformed cells correlates with their junctional communication with normal cells.

  1986cited by this paper
• Relation between colony formation in calcium-deficient medium, colony formation in soft agar, and tumor formation by T51B rat liver cells.

  1984cited by this paper
• REGULATION OF PROLIFERATION OF NORMAL AND NEOPLASTIC RAT LIVER CELLS BY CALCIUM AND CYCLIC AMP

  1980cited by this paper
• Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter.

  1979cited by this paper
• Intercellular Communication and the Control of Tissue Growth: Lack of Communication between Cancer Cells

  1966cited by this paper

• CDK5 activity in retinal pigment epithelium contributes to gap junction dynamics during phagocytosis

  2023cites this paper
• The Role of Connexin in Ophthalmic Neovascularization and the Interaction between Connexin and Proangiogenic Factors

  2022cites this paper
• Activation of PDGFRA signaling contributes to filamin C–related arrhythmogenic cardiomyopathy

  2022cites this paper
• Applicability of Scrape Loading-Dye Transfer Assay for Non-Genotoxic Carcinogen Testing

  2021cites this paper
• Bisphenol S enhances gap junction intercellular communication in ovarian theca cells.

  2020cites this paper
• Antagonistic Functions of Connexin 43 during the Development of Primary or Secondary Bone Tumors

  2020cites this paper
• A novel role of SIRT2 in regulating gap junction communications via connexin‐43 in bovine cumulus‐oocyte complexes

  2020cites this paper
• Connexins and Pannexins: Important Players in Tumorigenesis, Metastasis and Potential Therapeutics

  2018cites this paper
• Renal Interstitial Platelet-Derived Growth Factor Receptor-β Cells Support Proximal Tubular Regeneration.

  2018cites this paper
• The connexin 43 C-terminus: A tail of many tales.

  2018cites this paper
• Gap junction modulation and its implications for heart function

  2014cites this paper
• Intercellular Redistribution of cAMP Underlies Selective Suppression of Cancer Cell Growth by Connexin26

  2013cites this paper
• Post-Transcriptional Regulation of Connexin43 in H-Ras-Transformed Cells

  2013cites this paper
• FUNCTIONAL ADAPTATION OF THE RUMINAL EPITHELIUM

  2013cites this paper
• Platelet‐derived growth factor‐BB increases expression of connexin 43 in an extracellular‐regulated protein kinase‐dependent manner in bladder smooth muscle cells

  2013cites this paper
• Structural basis for the selective permeability of channels made of communicating junction proteins.

  2013influential citation
• The Regulation of TiPARP by the Aryl Hydrocarbon Receptor, the Platelet-derived Growth Factor Receptor, and the Estrogen Receptor Alpha

  2013cites this paper
• Coregulation of Multiple Signaling Mechanisms in pp60v-Src-Induced Closure of Cx43 Gap Junction Channels

  2012influential citation
• Primary Cultures of Embryonic Chick Lens Cells as a Model System to Study Lens Gap Junctions and Fiber Cell Differentiation

  2012cites this paper
• β-Catenin signaling contributes to platelet derived growth factor elicited bladder smooth muscle cell contraction through up-regulation of Cx43 expression.

  2012cites this paper
• Modulation of gap junction channels and hemichannels by growth factors.

  2012cites this paper
• MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

  2012cites this paper
• Connexins: sensors and regulators of cell cycling.

  2011cites this paper
• The role of platelet-derived growth factor in radiation injury to the lower urinary tract

  2011cites this paper
• Chloral hydrate decreases gap junction communication in rat liver epithelial cells

  2011cites this paper
• Angiogenesis inhibition in cancer therapy: platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy.

  2010cites this paper
• Indole-3-carbinol prevents H(2)O(2)-induced inhibition of gap junctional intercellular communication by inactivation of PKB/Akt.

  2008cites this paper
• Role of platelet-derived growth factors in physiology and medicine.

  2008cites this paper
• Protective Effect of the Natural Product, Chaetoglobosin K, on Lindane- and Dieldrin-induced Changes in Astroglia: Identification of Activated Signaling Pathways

  2008cites this paper
• Expression of connexin43 in rat epithelial cells and fibroblasts

  2008cites this paper
• Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells.

  2007cites this paper
• Remodeling of connexin 43 in the diabetic rat heart

  2006cites this paper
• Physiology of cardiovascular gap junctions.

  2006cites this paper
• Alterations of connexin 43 in the diabetic rat heart.

  2006cites this paper
• Connexin43 synthesis, phosphorylation, and degradation in regulation of transient inhibition of gap junction intercellular communication by the phorbol ester TPA in rat liver epithelial cells.

  2005cites this paper
• Nogo-66 Receptor at Cerebellar Cortical Glia Gap Junctions in the Rat

  2005cites this paper
• The phosphorylated form of connexin43 is up-regulated in breast hyperplasias and carcinomas and in their neoformed capillaries.

  2005cites this paper
• Expression of connexin43 in rat epithelial cells and fibroblasts.

  2005cites this paper
• Hypoxia/reoxygenation reduces microvascular endothelial cell coupling by a tyrosine and MAP kinase dependent pathway

  2005cites this paper
• Nerve growth factor increases connexin43 phosphorylation and gap junctional intercellular communication

  2005influential citation
• The effects of connexin phosphorylation on gap junctional communication.

  2004cites this paper
• Mechanism of regulation of the gap junction protein connexin 43 by protein kinase C-mediated phosphorylation.

  2004cites this paper
• Anisomycin downregulates gap-junctional intercellular communication via the p38 MAP-kinase pathway

  2004influential citation
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• Regulation of gap junctions by tyrosine protein kinases.

  2004cites this paper
• Plasma membrane channels formed by connexins: their regulation and functions.

  2003influential citation
• Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line

  2003cites this paper
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• Regulation of Epidermal Growth Factor-induced Connexin 43 Gap Junction Communication by Big Mitogen-activated Protein Kinase 1/ERK5 but Not ERK1/2 Kinase Activation*

  2003cites this paper
• Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence.

  2003cites this paper
• Einfluß der endothelialen Autakoide NO und PGI2 auf die Permeabilität endothelialer Gap Junctions

  2003cites this paper
• Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells

  2002cites this paper
• Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells.

  2002cites this paper
• The ovarian gap junction protein connexin43: regulation by gonadotropins.

  2002cites this paper
• Connexin43 in Rat Oocytes: Developmental Modulation of Its Phosphorylation1

  2002cites this paper
• 2',5'-Dihydroxychalcone down-regulates endothelial connexin43 gap junctions and affects MAP kinase activation.

  2002cites this paper
• Lipopolysaccharide‐induced reductions in cellular coupling correlate with tyrosine phosphorylation of connexin 43

  2002cites this paper
• Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways.

  2002cites this paper
• Gap junctions as targets for cancer chemoprevention and chemotherapy.

  2002cites this paper
• Mutagenic approaches to modifying gap junction phenotype.

  2002cites this paper
• Alteration of Cx 43 : Cx 40 expression ratio in A 7 r 5 cells

  2001cites this paper
• Cardiac gap junction channels: modulation of expression and channel properties.

  2001cites this paper
• A novel role for FGF and extracellular signal–regulated kinase in gap junction–mediated intercellular communication in the lens

  2001cites this paper
• Alteration of Cx43:Cx40 expression ratio in A7r5 cells.

  2001cites this paper
• Role of PKC and MAP kinase in EGF- and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells.

  2001influential citation
• Insulin, insulin-like growth factor-I, and platelet-derived growth factor activate extracellular signal-regulated kinase by distinct pathways in muscle cells.

  2001cites this paper
• Identification of a protein kinase activity that phosphorylates connexin43 in a pH-dependent manner.

  2000cites this paper
• Age-related Alteration of Gap Junction Distribution and Connexin Expression in Rat Aortic Endothelium

  2000cites this paper
• Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway

  2000cites this paper
• Dynamic connexin43 expression and gap junctional communication during endoderm differentiation of F9 embryonal carcinoma cells.

  2000cites this paper
• Regulation of gap junctions by phosphorylation of connexins.

  2000cites this paper
• Regulation of Cx43 Gap Junctions: The Gatekeeper and the Password

  2000cites this paper
• PDGF regulates gap junction communication and connexin43 phosphorylation by PI 3-kinase in mesangial cells.

  2000cites this paper
• Resveratrol reverses tumor-promoter-induced inhibition of gap-junctional intercellular communication.

  2000cites this paper
• Chapter 15: Regulation of Connexin43 by Tyrosine Protein Kinases

  1999cites this paper
• Chapter 24: Role of Gap Junctions in Cellular Growth Control and Neoplasia: Evidence and Mechanisms

  1999cites this paper
• Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity.

  1999cites this paper
• Mitogen‐activated protein kinase and phosphorylation of connexin43 are not sufficient for the disruption of gap junctional communication by platelet‐derived growth factor and tetradecanoylphorbol acetate

  1999cites this paper
• Stimulated phosphorylation of intracellular connexin43.

  1999cites this paper
• Disruption of Gap Junctional Communication by the Platelet-derived Growth Factor Is Mediated via Multiple Signaling Pathways*

  1999cites this paper
• Pretreatment with eicosapentaenoic acid prevented hypoxia/reoxygenation-induced abnormality in endothelial gap junctional intercellular communication through inhibiting the tyrosine kinase activity.

  1999cites this paper