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Multiscale Modeling Framework for Lung Airways Inflammation

R. Pidaparti,K. Koombua,K. Ward

Published 2012 in International Conference on Conceptual Structures

ABSTRACT

Abstract Better understanding of the acute/chronic inflammation in airways is very important in to order avoid lung injuries for patients undergoing mechanical ventilation. Inflammation is a complex and dynamic process triggered by many mechanisms within the lung and involves multiple scales starting from organ level to cellular level. In this study, a multiscale modeling framework is being developed to address the cellular inflammation due to mechanical ventilation at the organ level. The developed multiscale modeling framework is illustrated through a case study to investigate inflammatory responses at the alveolar sac during mechanical ventilation. The simulation results showed that high tidal volume (1400 cc) during mechanical ventilation can cause tissue injury due to high concentration of activated immune cells. These results can be further extended to investigate the effects of mechanical ventilation parameters.

PUBLICATION RECORD

  • Publication year

    2012

  • Venue

    International Conference on Conceptual Structures

  • Publication date

    Unknown publication date

  • Fields of study

    Medicine, Computer Science, Engineering, Environmental Science

  • Identifiers
    DOI 10.1016/j.procs.2012.04.065
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

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