Prenatal letrozole produces a subpopulation of male rats with same-sex preference and arousal as well as female sexual behavior.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Physiology and Behavior

• Publication date

  2015-02-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.physbeh.2014.11.060PMID 25462593
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2002influential reference
• Influence of sex and estrus cycle on the sexual dimorphisms of the hypothalamic ventromedial nucleus: Stereological evaluation and golgi study

  2001cited by this paper
• Conditioning and sexual behavior: a review.

  2001cited by this paper
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  1999cited by this paper
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  1996influential reference
• Sex hormone modulation of flow velocity in the parametrial artery of the pregnant rat.

  1995cited by this paper
• Endogenous reproductive hormones and nocturnal rhythms in partner preference and sexual behavior of ATD-treated male rats.

  1995influential reference
• Sex-steroid receptor mechanism related to neuronal aromatase and the stigmoid body.

  1994cited by this paper
• SDN-POA volume, sexual behavior, and partner preference of male rats affected by perinatal treatment with ATD.

  1994cited by this paper
• A semiautomated test apparatus for studying partner preference behavior in the rat.

  1994influential reference
• Noncontact stimulation from estrous females evokes penile erection in rats.

  1994cited by this paper
• Metabolic aspects of the 1 beta-proton and the 19-methyl group of androst-4-ene-3,6,17-trione during aromatization by placental microsomes and inactivation of aromatase.

  1994cited by this paper
• Organization of partner preference and sexual behavior and its nocturnal rhythmicity in male rats.

  1993influential reference
• Hormonal regulation of adult partner preference behavior in neonatally ATD-treated male rats.

  1993influential reference
• Sexual orientation and sexual motivation of the adult male rat.

  1993cited by this paper
• Luteinizing hormone, testosterone, and behavioral response of male-oriented rams to estrous ewes and rams.

  1992cited by this paper
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  1991cited by this paper
• Adult partner preference and sexual behavior of male rats affected by perinatal endocrine manipulations.

  1991cited by this paper
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  1991cited by this paper
• Olfactory bulb removal: effects on sexual behavior and partner-preference in male rats.

  1990cited by this paper
• Sexual motivation: a neural and behavioural analysis of the mechanisms underlying appetitive and copulatory responses of male rats.

  1990cited by this paper
• Dilute estradiol implants and progestin receptor induction in the ventromedial nucleus of the hypothalamus: correlation with receptive behavior in female rats.

  1989cited by this paper
• Effects of ATD on male sexual behavior and androgen receptor binding: a reexamination of the aromatization hypothesis.

  1989cited by this paper
• Sexual behavior and sexual orientation of the female rat after hormonal treatment during various stages of development.

  1988cited by this paper
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  1988cited by this paper
• Homosexual and heterosexual partner preference in ovariectomized female rats: effects of testosterone, estradiol and mating experience.

  1987cited by this paper
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  1986cited by this paper
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  1986cited by this paper
• Estrogen formation in the developing rat brain: sex differences in aromatase activity during early post-natal life.

  1985cited by this paper
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  1981cited by this paper
• Sexual differentiation of the central nervous system.

  1981cited by this paper
• Role of aromatization in sexual differentiation: effects of prenatal ATD treatment and neonatal castration.

  1981cited by this paper
• Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offspring.

  1980cited by this paper
• Sex-specific orientation in the male rat. A methodological study.

  1978cited by this paper
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  1978cited by this paper
• Feminine sexual behavior in rats enhanced by prenatal inhibition of androgen aromatization.

  1978cited by this paper
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  1977cited by this paper
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  1970cited by this paper
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  2020cites this paper
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  2020cites this paper
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