Cervical Spinal Cord Injury Upregulates Ventral Spinal 5-HT2A Receptors

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Neurotrauma

• Publication date

  2005-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1089/neu.2005.22.203PMID 15716627
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The 5‐HT2A receptor is widely distributed in the rat spinal cord and mainly localized at the plasma membrane of postsynaptic neurons

  2004cited by this paper
• Serotonin reveals ineffective spinal pathways to contralateral phrenic motoneurons in spinally hemisected rats

  2004influential reference
• BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia

  2004cited by this paper
• Breathing: rhythmicity, plasticity, chemosensitivity.

  2003cited by this paper
• Effects of long-term theophylline exposure on recovery of respiratory function and expression of adenosine A1 mRNA in cervical spinal cord hemisected adult rats.

  2003cited by this paper
• Invited Review: Neuroplasticity in respiratory motor control

  2003influential reference
• Synaptic Pathways to Phrenic Motoneurons Are Enhanced by Chronic Intermittent Hypoxia after Cervical Spinal Cord Injury

  2003influential reference
• Invited review: Mechanisms underlying motor unit plasticity in the respiratory system.

  2003cited by this paper
• The crossed phrenic phenomenon: a model for plasticity in the respiratory pathways following spinal cord injury.

  2003influential reference
• Respiratory Motor Recovery after Unilateral Spinal Cord Injury: Eliminating Crossed Phrenic Activity Decreases Tidal Volume and Increases Contralateral Respiratory Motor Output

  2003cited by this paper
• Neuroplasticity in respiratory motor control.

  2003cited by this paper
• Theophylline-induced respiratory recovery following cervical spinal cord hemisection is augmented by serotonin 2 receptor stimulation.

  2002cited by this paper
• Chronic cervical spinal sensory denervation reveals ineffective spinal pathways to phrenic motoneurons in the rat.

  2002cited by this paper
• Actions of specific adenosine receptor A1 and A2 agonists and antagonists in recovery of phrenic motor output following upper cervical spinal cord injury in adult rats

  2002cited by this paper
• Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia.

  2001cited by this paper
• Cervical spinal cord injury alters the pattern of breathing in anesthetized rats.

  2001influential reference
• Serotonin(2) receptors mediate respiratory recovery after cervical spinal cord hemisection in adult rats.

  2001influential reference
• Chronic Intermittent Hypoxia Elicits Serotonin-Dependent Plasticity in the Central Neural Control of Breathing

  2001influential reference
• Altered Respiratory Motor Drive after Spinal Cord Injury: Supraspinal and Bilateral Effects of a Unilateral Lesion

  2001influential reference
• Distribution of serotonin 2A and 2C receptor mRNA expression in the cervical ventral horn and phrenic motoneurons following spinal cord hemisection.

  2001influential reference
• Progress in Spinal Cord Research - A refined strategy for the International Spinal Research Trust

  2000cited by this paper
• 5-Hydroxytryptophan-induced respiratory recovery after cervical spinal cord hemisection in rats.

  2000cited by this paper
• Effects of serotonin inhibition on neuronal and astrocyte plasticity in the phrenic nucleus 4 h following C2 spinal cord hemisection.

  1999cited by this paper
• Effects of serotonin on crossed phrenic nerve activity in cervical spinal cord hemisected rats.

  1999cited by this paper
• Effects of the serotonin synthesis inhibitor p-CPA on the expression of the crossed phrenic phenomenon 4 h following C2 spinal cord hemisection.

  1999cited by this paper
• Spontaneous Functional Recovery in a Paralyzed Hemidiaphragm Following Upper Cervical Spinal Cord Injury in Adult Rats

  1999influential reference
• Functional chemical neuroanatomy of serotonergic neurons and their targets: antibody production and immunohistochemistry (IHC) for 5-HT, its precursor (5-HTP) and metabolite (5-HIAA), biosynthetic enzyme (TPH), transporter (SERT), and three receptors (5-HT2A, 5-ht5a, 5-HT7).

  1998cited by this paper
• Cervical Dorsal Rhizotomy Enhances Serotonergic Innervation of Phrenic Motoneurons and Serotonin-Dependent Long-Term Facilitation of Respiratory Motor Output in Rats

  1998cited by this paper
• Asymmetric bipedal locomotion – an adaptive response to incomplete spinal injury in the chick

  1998cited by this paper
• Synaptic plasticity of 5‐hydroxytryptamine–immunoreactive terminals in the phrenic nucleus following spinal cord injury: A quantitative electron microscopic analysis

  1997cited by this paper
• Ultrastructural quantitative analysis of glutamatergic and GABAergic synaptic terminals in the phrenic nucleus after spinal cord injury

  1996cited by this paper
• The recovery of 5-HT immunoreactivity in lumbosacral spinal cord and locomotor function after thoracic hemisection.

  1996influential reference
• Glutamate, GABA, and serotonin in ventilatory control

  1995cited by this paper
• Ultrastructural changes in the rat phrenic nucleus developing within 2 h after cervical spinal cord hemisection.

  1993cited by this paper
• Respiratory complications and management of spinal cord injuries.

  1990cited by this paper
• Biometry: The Principles and Practice of Statistics in Biological Research (2nd ed.).

  1982cited by this paper
• Biometry: The Principles and Practice of Statistics in Biological Research

  1969cited by this paper
• highlighted topics Physiological and Genomic Consequences of Intermittent Hypoxia Selected Contribution: Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia

  year unknowncited by this paper
• highlighted topics Physiological and Genomic Consequences of Intermittent Hypoxia Invited Review: Intermittent hypoxia and respiratory plasticity

  year unknowninfluential reference

• Mirtazapine Improves Locomotor Activity and Attenuates Neuropathic Pain Following Spinal Cord Injury in Rats via Neuroinflammation Modulation

  2024cites this paper
• Prolonged intermittent hypoxia differentially regulates phrenic motor neuron serotonin receptor expression in rats following chronic cervical spinal cord injury.

  2024influential citation
• BDNF-TrkB Signaling Pathway in Spinal Cord Injury: Insights and Implications

  2024cites this paper
• Covert actions of epidural stimulation on spinal locomotor circuits

  2024cites this paper
• Subclinical respiratory dysfunction and impaired ventilatory adaptation in degenerative cervical myelopathy.

  2023cites this paper
• The Development of Hindlimb Postural Asymmetry Induced by Focal Traumatic Brain Injury Is Not Related to Serotonin 2A/C Receptor Expression in the Spinal Cord

  2022cites this paper
• Role of Descending Serotonergic Fibers in the Development of Pathophysiology after Spinal Cord Injury (SCI): Contribution to Chronic Pain, Spasticity, and Autonomic Dysreflexia

  2022cites this paper
• Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns

  2022cites this paper
• Spinal Cord Injury Alters Spinal Shox2 Interneurons by Enhancing Excitatory Synaptic Input and Serotonergic Modulation While Maintaining Intrinsic Properties in Mouse

  2021influential citation
• Electrical epidural stimulation of the cervical spinal cord: Implications for spinal respiratory neuroplasticity after spinal cord injury.

  2021cites this paper
• Prelude to the special issue on novel neurocircuit, cellular and molecular targets for developing functional rehabilitation therapies of neurotrauma.

  2021cites this paper
• Diaphragm Motor-Evoked Potential Induced by Cervical Magnetic Stimulation following Cervical Spinal Cord Contusion in the Rat

  2021cites this paper
• Respiratory axon regeneration in the chronically injured spinal cord.

  2021cites this paper
• Rostral-Caudal Effect of Cervical Magnetic Stimulation on the Diaphragm Motor Evoked Potential after Cervical Spinal Cord Contusion in the Rat

  2021cites this paper
• Phrenic motor neuron survival below cervical spinal cord hemisection.

  2021cites this paper
• Spinal cord injury and diaphragm neuromotor control

  2020cites this paper
• Ampakines stimulate phrenic motor output after cervical spinal cord injury.

  2020cites this paper
• 5-HT7 Receptor Inhibition Transiently Improves Respiratory Function Following Daily Acute Intermittent Hypercapnic-Hypoxia in Rats With Chronic Midcervical Spinal Cord Contusion

  2020cites this paper
• Serotonin in Central Cardiovascular Regulation

  2019cites this paper
• Spontaneous respiratory plasticity following unilateral high cervical spinal cord injury in behaving rats

  2018cites this paper
• Intraspinal Grafting of Serotonergic Neurons Modifies Expression of Genes Important for Functional Recovery in Paraplegic Rats

  2018cites this paper
• Anatomical Recruitment of Spinal V2a Interneurons into Phrenic Motor Circuitry after High Cervical Spinal Cord Injury

  2017cites this paper
• Enhancing neural activity to drive respiratory plasticity following cervical spinal cord injury.

  2017cites this paper
• Impact of glutamatergic and serotonergic neurotransmission on diaphragm muscle activity after cervical spinal hemisection.

  2017influential citation
• Contribution of 5-HT2A receptors on diaphragmatic recovery after chronic cervical spinal cord injury.

  2017cites this paper
• Functional recovery after cervical spinal cord injury: Role of neurotrophin and glutamatergic signaling in phrenic motoneurons.

  2016cites this paper
• TrkB gene therapy by adeno-associated virus enhances recovery after cervical spinal cord injury.

  2016cites this paper
• Serotonergic activation of locomotor behavior and posture in one-day old rats.

  2016cites this paper
• Performance Evaluation for the Sustainable Supply Chain Management

  2016cites this paper
• erotonergic activation of locomotor behavior and posture in one-day ld rats illary

  2016cites this paper
• Neuroprotective and Neurorestorative Processes after Spinal Cord Injury: The Case of the Bulbospinal Respiratory Neurons

  2016cites this paper
• Normal Distribution and Plasticity of Serotonin Receptors after Spinal Cord Injury and Their Impacts on Motor Outputs

  2016cites this paper
• Intermittent hypoxia promotes recovery of respiratory motor function in spinal cord-injured mice depleted of serotonin in the central nervous system.

  2016cites this paper
• The role of the serotonergic system in locomotor recovery after spinal cord injury

  2015cites this paper
• Effects of serotonergic agents on respiratory recovery after cervical spinal injury.

  2015cites this paper
• Spinal Interneurons and Forelimb Plasticity after Incomplete Cervical Spinal Cord Injury in Adult Rats

  2015cites this paper
• Chronic Intermittent Hypoxia Blunts the Expression of Ventilatory Long Term Facilitation in Sleeping Rats.

  2015cites this paper
• Phrenic Long-Term Facilitation Requires PKCθ Activity within Phrenic Motor Neurons

  2015cites this paper
• Daily acute intermittent hypoxia elicits functional recovery of diaphragm and inspiratory intercostal muscle activity after acute cervical spinal injury.

  2015cites this paper
• Intermittent hypoxia: a low-risk research tool with therapeutic value in humans.

  2015cites this paper
• cervical spinal hemisection in rats Recovery of phrenic activity and ventilation after

  2015cites this paper
• Drawing breath without the command of effectors: the control of respiration following spinal cord injury.

  2014cites this paper
• Recovery of the pulmonary chemoreflex and functional role of bronchopulmonary C-fibers following chronic cervical spinal cord injury.

  2014cites this paper
• Therapeutic Potential of Intermittent Hypoxia: Lessons from Respiratory Motor Plasticity

  2014cites this paper
• Reprint of "Drawing breath without the command of effectors: the control of respiration following spinal cord injury".

  2014cites this paper
• Traumatic injury induces changes in the expression of the serotonin 1A receptor in the spinal cord of lampreys.

  2014cites this paper
• The challenges of respiratory motor system recovery following cervical spinal cord injury.

  2014cites this paper
• Quantitative expression profiling in mouse spinal cord reveals changing relationships among channel and receptor mRNA levels across postnatal maturation.

  2014cites this paper
• Phrenic motoneuron discharge patterns following chronic cervical spinal cord injury.

  2013cites this paper
• Targeted Delivery of TrkB Receptor to Phrenic Motoneurons Enhances Functional Recovery of Rhythmic Phrenic Activity after Cervical Spinal Hemisection

  2013influential citation
• The role of the crossed phrenic pathway after cervical contusion injury and a new model to evaluate therapeutic interventions.

  2013cites this paper
• Repetitive acute intermittent hypoxia increases expression of proteins associated with plasticity in the phrenic motor nucleus.

  2012cites this paper
• Neurobiological perspective of spasticity as occurs after a spinal cord injury.

  2012cites this paper
• Treatments to restore respiratory function after spinal cord injury and their implications for regeneration, plasticity and adaptation.

  2012cites this paper
• Phrenic motoneuron expression of serotonergic and glutamatergic receptors following upper cervical spinal cord injury.

  2012influential citation
• Functional regeneration of respiratory pathways after spinal cord injury

  2011cites this paper
• The time course of serotonin 2A receptor expression after spinal transection of rats: an immunohistochemical study.

  2011cites this paper
• Contribution of 5‐HT to locomotion – the paradox of Pet‐1−/− mice

  2011cites this paper
• The time course of serotonin 2C receptor expression after spinal transection of rats: an immunohistochemical study.

  2011cites this paper
• Spinal plasticity following intermittent hypoxia: implications for spinal injury

  2010cites this paper
• Cough following low thoracic hemisection in the cat.

  2010cites this paper
• Robust upregulation of serotonin 2A receptors after chronic spinal transection of rats: an immunohistochemical study.

  2010influential citation
• Differential expression of respiratory long-term facilitation among inbred rat strains.

  2010cites this paper
• Recovery of control of posture and locomotion after a spinal cord injury: solutions staring us in the face.

  2009cites this paper
• Role of neurotrophins in recovery of phrenic motor function following spinal cord injury.

  2009cites this paper
• Localization of serotoninergic neurons that participate in regulating diaphragm activity in the cat.

  2009cites this paper
• Respiratory recovery following high cervical hemisection.

  2009cites this paper
• Alteration of the H-reflex after compression spinal cord injury in mice (Mus musculus, Linné 1758)

  2009cites this paper
• Intermittent hypoxia induces functional recovery following cervical spinal injury.

  2009cites this paper
• The crossed phrenic phenomenon and recovery of function following spinal cord injury.

  2009cites this paper
• Muscarinic control of the excitability of hindlimb motoneurons in chronic spinal‐transected salamanders

  2008cites this paper
• Role of spinal 5‐HT2 receptor subtypes in quipazine‐induced hindlimb movements after a low‐thoracic spinal cord transection

  2008influential citation
• Respiratory plasticity following intermittent hypoxia: a guide for novel therapeutic approaches to ventilatory control disorders?

  2008cites this paper
• Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats.

  2008cites this paper
• Respiratory neuroplasticity and cervical spinal cord injury: translational perspectives.

  2008cites this paper
• Glutamate receptor plasticity and activity-regulated cytoskeletal associated protein regulation in the phrenic motor nucleus may mediate spontaneous recovery of the hemidiaphragm following chronic cervical spinal cord injury.

  2008cites this paper
• Up-regulation of 5-HT2 receptors is involved in the increased H-reflex amplitude after contusive spinal cord injury.

  2007influential citation
• Respiratory plasticity following intermittent hypoxia: roles of protein phosphatases and reactive oxygen species.

  2007cites this paper
• Spinal cord injury in neonates alters respiratory motor output via supraspinal mechanisms.

  2007cites this paper
• Changes in vesicular glutamate transporter 2, vesicular GABA transporter and vesicular acetylcholine transporter labeling of sacrocaudal motoneurons in the spastic rat.

  2006cites this paper
• Differential motor and electrophysiological outcome in rats with mid-thoracic or high lumbar incomplete spinal cord injuries.

  2006cites this paper
• Involvement of Peripheral Adenosine A2 Receptors in Adenosine A1 Receptor-Mediated Recovery of Respiratory Motor Function After Upper Cervical Spinal Cord Hemisection

  2006cites this paper
• Recovery of phrenic activity and ventilation after cervical spinal hemisection in rats.

  2006cites this paper
• Spinal Synaptic Enhancement with Acute Intermittent Hypoxia Improves Respiratory Function after Chronic Cervical Spinal Cord Injury

  2005cites this paper
• Effects of carotid body excision on recovery of respiratory function in C2 hemisected adult rats.

  2005cites this paper
• Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats

  2005cites this paper