Substance P and Histamine Induce Interleukin‐6 Expression in Human Astrocytoma Cells by a Mechanism Involving Protein Kinase C and Nuclear Factor‐IL‐6

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Neurochemistry

• Publication date

  1998-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1471-4159.1998.70041577.xPMID 9523575
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients

  2004cited by this paper
• Potent inhibition of interleukin-6 expression in a human astrocytoma cell line by tenidap

  1997cited by this paper
• Prostaglandin E2 Induces Interleukin‐6 Synthesis in Human Astrocytoma Cells

  1997cited by this paper
• Expression of Tumor Necrosis Factor α (TNFα) and Interleukin 6 (IL‐6) mRNA in Adult Human Astrocytes: Comparison with Adult Microglia and Fetal Astrocytes

  1996cited by this paper
• Interleukin-1 beta uses common and distinct signaling pathways for induction of the interleukin-6 and tumor necrosis factor alpha genes in the human astrocytoma cell line U373.

  1996cited by this paper
• Adenosine A2b Receptors Mediate an Increase in Interleukin (IL)‐6 mRNA and IL‐6 Protein Synthesis in Human Astroglioma Cells

  1996cited by this paper
• Expression of tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6) mRNA in adult human astrocytes: comparison with adult microglia and fetal astrocytes.

  1996cited by this paper
• Interleukin‐1β and Tumor Necrosis Factor‐α Induce Expression of α1‐Antichymotrypsin in Human Astrocytoma Cells by Activation of Nuclear Factor‐κB

  1996cited by this paper
• Antioxidant and redox regulation of gene transcription

  1996cited by this paper
• Interleukin‐1β Uses Common and Distinct Signaling Pathways for Induction of the Interleukin‐6 and Tumor Necrosis Factor α Genes in the Human Astrocytoma Cell Line U373

  1996cited by this paper
• Effects of NSAIDs on IL‐1β‐induced IL‐6 mRNA and protein synthesis in human astrocytoma cells

  1996cited by this paper
• Interleukin-1 beta and tumor necrosis factor-alpha induce expression of alpha 1-antichymotrypsin in human astrocytoma cells by activation of nuclear factor-kappa B.

  1996cited by this paper
• Redox signalling by transcription factors NF-κB and AP-1 in lymphocytes

  1995cited by this paper
• Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1.

  1995cited by this paper
• Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes.

  1995cited by this paper
• Interleukin-6 in human multiple myeloma.

  1995cited by this paper
• Stimulation of the sphingomyelin pathway induces interleukin-6 gene expression in human astrocytoma cells

  1995cited by this paper
• Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells.

  1995cited by this paper
• Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha.

  1994cited by this paper
• Interleukin-6 secretion from human astrocytoma cells induced by substance P.

  1994cited by this paper
• Cytokine circuits in brain. Implications for AIDS dementia complex.

  1994cited by this paper
• Regulation of the Release of Interleukin‐6 from Human Astrocytoma Cells

  1994cited by this paper
• Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide

  1994cited by this paper
• Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1 beta or IL-1RA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein.

  1993cited by this paper
• Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

  1993cited by this paper
• Human immunodeficiency virus type 1 infection of the nervous system: Pathogenetic mechanisms

  1993cited by this paper
• Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1β or IL-1RA but increases in the associated acute phase proteins IL-6, α2-macroglobulin and C-reactive protein

  1993cited by this paper
• Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: Synergism with IL-1β and TNFα

  1993cited by this paper
• Cytokine mRNA expression in inflammatory multiple sclerosis lesions: detection by non-radioactive in situ hybridization.

  1993cited by this paper
• Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: synergism with IL-1 beta and TNF alpha.

  1993cited by this paper
• Cytokine expression in the brain during the acquired immunodeficiency syndrome

  1992cited by this paper
• Regulation of IL6 gene expression.

  1992cited by this paper
• Proinflammatory and Antiinflammatory Cytokines in Multiple Sclerosis and Central Nervous System Acquired Immunodeficiency Syndrome

  1992cited by this paper
• Inflammatory mediators in demyelinating disorders of the CNS and PNS.

  1992cited by this paper
• IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection

  1992cited by this paper
• Interleukin-6 and its receptor in autoimmunity.

  1992cited by this paper
• Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices.

  1991cited by this paper
• I kappa B: a specific inhibitor of the NF-kappa B transcription factor.

  1988cited by this paper

• Radiotherapy Plus the Neurokinin-1 Receptor Antagonist Aprepitant: A Potent Therapeutic Strategy for the Treatment of Diffuse Intrinsic Pontine Glioma

  2025cites this paper
• Evaluating the Role of N-Acetyl-L-Tryptophan in the Aβ 1-42-Induced Neuroinflammation and Cognitive Decline in Alzheimer’s Disease

  2023cites this paper
• Didymin Exhibits Different Cytotoxicity Patterns on U-87 MG Human Glioblastoma Cells and Orchestrates the Release of Substance P (SP) and Interleukin-6 (IL-6) in a Time Depending Manner

  2023cites this paper
• Anti-Inflammatory Action of Dexmedetomidine on Human Microglial Cells

  2022cites this paper
• Yokukansan, a Japanese Herbal Medicine, suppresses Substance P-induced Production of Interleukin-6 and Interleukin-8 by Human U373 MG Glioblastoma Astrocytoma Cells.

  2020cites this paper
• The role of matrix metalloproteinases in cancer progression, in particular metastasis

  2018influential citation
• The role of substance P in cancer promotion and progression

  2018cites this paper
• Anti‑inflammatory actions of gabapentin and pregabalin on the substance P‑induced mitogen‑activated protein kinase activation in U373 MG human glioblastoma astrocytoma cells.

  2017influential citation
• Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG glioblastoma/astrocytoma cells.

  2017cites this paper
• Abstract. Gabapentin (GBP) and pregabalin (PGB) exert antinociceptive effects on chronic nociceptive responses with neuropathic or inflammatory conditions. Furthermore, it is considered that GBP and PGB exhibit anti‐inflammatory effects by modulating the substance P (SP)‐mediated neuro- kinin‐1 rece

  2017influential citation
• Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG glioblastoma/astrocytoma cells.

  2017cites this paper
• Roles of Substance P in Gastrointestinal Functions and Neuroimmune Interactions

  2016cites this paper
• Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation

  2016cites this paper
• Diagnostic relevance of CSF interleukin-6

  2016cites this paper
• Role of astrocytic IL-6 and IL-6R in normal physiology and neuroinflammation

  2014cites this paper
• Analog of Somatostatin Vapreotide Exhibits Biological Effects in vitro via Interaction with Neurokinin-1 Receptor

  2013cites this paper
• The induction and effects of Substance P and its receptor in human immune cells and neurons : potential relevance in multiple sclerosis

  2012cites this paper
• Interleukin-6, a Major Cytokine in the Central Nervous System

  2012cites this paper
• Examining the Effect of the Context of Heat-Labile Enterotoxin Presentation on the Host Immune Response

  2011cites this paper
• Context-Dependent Activation Kinetics Elicited by Soluble versus Outer Membrane Vesicle-Associated Heat-Labile Enterotoxin

  2011cites this paper
• Substance P Signaling Contributes to Granuloma Formation in Taenia crassiceps Infection, a Murine Model of Cysticercosis

  2010cites this paper
• Substance P is required for the pathogenesis of EMCV infection in mice.

  2009cites this paper
• Mechanisms of Glial Activation after Nerve Injury

  2008cites this paper
• , Prema sp . Infection Cryptosporidium Intestinal Immune Response to Human

  2007cites this paper
• Does the Heat Stress Affect the Neurons Development in Some Central Nervous System Regions of Albino Rat Newborns

  2007cites this paper
• Intestinal Immune Response to Human Cryptosporidium sp. Infection

  2007cites this paper
• SUBSTANCE P IS ASSOCIATED WITH HEART ENLARGEMENT AND APOPTOSIS IN MURINE DILATED CARDIOMYOPATHY INDUCED BY TAENIA CRASSICEPS INFECTION

  2007cites this paper
• Chapter 22 Contribution of glia to pain processing in health and disease.

  2006cites this paper
• Tachykinins and their receptors in human malignancies.

  2006cites this paper
• Substance P induces expression of the corticotropin-releasing factor receptor 1 by activation of the neurokinin-1 receptor.

  2006cites this paper
• No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress.

  2006cites this paper
• Serotonin via 5‐HT7 receptors activates p38 mitogen‐activated protein kinase and protein kinase C ɛ resulting in interleukin‐6 synthesis in human U373 MG astrocytoma cells

  2005cites this paper
• IL-6 expression induced by adenosine A2b receptor stimulation in U373 MG cells depends on p38 mitogen activated kinase and protein kinase C.

  2005cites this paper
• Auswirkungen der Bestrahlung mit UVB, UVA-1 und PUVA-1 auf das Funktionsverhalten humaner dermaler Mastzellen nach Stimulation mit anti-IgE und Substanz P

  2004cites this paper
• Progress in deciphering the genetics of multiple sclerosis.

  2003cites this paper
• Neurokinin-1 Receptor Expression and Its Potential Effects on Tumor Growth in Human Pancreatic Cancer

  2003cites this paper
• Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain.

  2003cites this paper
• Valproic acid inhibits substance P‐induced activation of protein kinase C epsilon and expression of the substance P receptor

  2003cites this paper
• Substance P and Substance P Receptor Antagonists in the Pathogenesis and Treatment of Affective Disorders

  2003cites this paper
• Mechanisms by which Lipid Derivatives and Proteinases Signal to Primary Sensory Neurons: Implications for Inflammation and Pain

  2003cites this paper
• Neurotransmitters are regulators for the migration of tumor cells and leukocytes

  2002cites this paper
• Substance P and Affective Disorders: New Treatment Opportunities by Neurokinin 1 Receptor Antagonists?

  2002cites this paper
• Inverse regulation of interleukin-6 (IL-6) and IL-6 receptor in histamine deficient histidine decarboxylase-knock-out mice.

  2002cites this paper
• Histamine-Deficient Mice Experimental Peritonitis of in Escherichia coli Accelerated Clearance of

  2002cites this paper
• Accelerated Clearance of Escherichia coli in Experimental Peritonitis of Histamine-Deficient Mice1

  2002cites this paper
• Involvement of substance P, mast cells, TNF-alpha and ICAM-1 in the infiltration of inflammatory cells in human periapical granulomas.

  2002cites this paper
• Modulation of somatostatin receptors, somatostatin content and Gi proteins by substance P in the rat frontoparietal cortex and hippocampus

  2002cites this paper
• Pulsed electromagnetic fields affect the intracellular calcium concentrations in human astrocytoma cells

  2001cites this paper
• Glial activation: a driving force for pathological pain.

  2001cites this paper
• Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology.

  2001cites this paper
• Inhibition of Substance P-Induced Cytokine Synthesis by St. John's Wort Extracts

  2001cites this paper
• Increased neuronal and glial expression of protein kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology

  2001cites this paper
• Mechanisms of prostaglandin E2‐induced interleukin‐6 release in astrocytes: possible involvement of EP4‐like receptors, p38 mitogen‐activated protein kinase and protein kinase C

  2001cites this paper
• An altered histaminergic innervation of the substantia nigra in Parkinson's disease.

  2000cites this paper
• Adenosine‐induced expression of interleukin‐6 in astrocytes through protein kinase A and NF‐IL‐6

  2000cites this paper
• Autoregulation of the interleukin-1 system and cytokine-cytokine interactions in primary human astrocytoma cells.

  2000cites this paper
• Rabbit pigmented ciliary epithelium produces interleukin-6 in response to inflammatory cytokines.

  2000cites this paper
• Substance P differentially stimulates IL-8 synthesis in human corneal epithelial cells.

  2000cites this paper
• The role of tachykinins via NK1 receptors in progression of human gliomas.

  2000cites this paper
• The effect of pulsed electromagnetic fields on the physiologic behaviour of a human astrocytoma cell line.

  2000cites this paper
• The Neuropeptide Substance P Activates p38 Mitogen-Activated Protein Kinase Resulting in IL-6 Expression Independently from NF-κB1

  2000cites this paper
• Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cbeta.

  2000cites this paper
• Biosynthesis of interleukin-6, an autocrine growth factor for melanoma, is regulated by melanoma-derived histamine.

  2000cites this paper
• Acute peripheral inflammation induces moderate glial activation and spinal IL-1β expression that correlates with pain behavior in the rat

  1999cites this paper
• Differential injury-dependent glial expression of interleukins-1 alpha, beta, and interleukin-6 in rat brain.

  1999cites this paper
• Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat.

  1999cites this paper
• Bradykinin Induces Interleukin‐6 Expression in Astrocytes Through Activation of Nuclear Factor‐κB

  1999cites this paper
• Interleukin‐6 Activates Signal Transducer and Activator of Transcription and Mitogen‐Activated Protein Kinase Signal Transduction Pathways and Induces De Novo Protein Synthesis in Human Neuronal Cells

  1999cites this paper
• Interleukin-6 expression and regulation in astrocytes.

  1999cites this paper
• The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha1-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IkappaB-alpha.

  1999cites this paper
• From humoral fever to neuroimmunological control of fever

  1999cites this paper
• Differential injury‐dependent glial expression of interleukins‐1α, β, and interleukin‐6 in rat brain

  1999cites this paper