The effect of Tityus serrulatus scorpion toxin gamma on Na channels in neuroblastoma cells.

No abstract is available for this paper.

• Publication year

  1984

• Venue

  Pflügers Archiv: European Journal of Physiology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 6089101
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tityusγ toxin, a high affinity effector of the Na+ channel in muscle, with a selectivity for channels in the surface membrane

  2004cited by this paper
• Electrophysiological characterization, solubilization and purification of the Tityus gamma toxin receptor associated with the gating component of the Na+ channel from rat brain.

  1983cited by this paper
• Isolation and characterization of toxic proteins from the venom of the Brazilian scorpion Tityus serrulatus.

  1983cited by this paper
• Purification of binding protein for Tityus gamma toxin identified with the gating component of the voltage-sensitive Na+ channel.

  1983cited by this paper
• A quantitative study of the action ofCentruroides sculpturatus toxins III and IV on the Na currents of the node of Ranvier

  1983cited by this paper
• Classification of Na channel receptors specific for various scorpion toxins

  1983cited by this paper
• Molecular size of different neurotoxin receptors on the voltage-sensitive Na+ channel.

  1983cited by this paper
• Modification of single Na+ channels by batrachotoxin.

  1982cited by this paper
• Tityus serrulatus venom contains two classes of toxins. Tityus gamma toxin is a new tool with a very high affinity for studying the Na+ channel.

  1982cited by this paper
• Two types of scorpion receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel.

  1982cited by this paper
• Batrachotoxin modifies the gating kinetics of sodium channels in internally perfused neuroblastoma cells.

  1982cited by this paper
• Effect of toxins isolated from the venom of the scorpionCentruroides sculpturatus on the Na currents of the node of ranvier

  1982cited by this paper
• Centruroides toxin, a selective blocker of surface Na+ channels in skeletal muscle: voltage-clamp analysis and biochemical characterization of the receptor.

  1982cited by this paper
• Some kinetic and steady-state properties of sodium channels after removal of inactivation

  1981cited by this paper
• Fluctuation analysis of Na+ channels modified by batrachotoxin in myelinated nerve.

  1981cited by this paper
• MOLECULAR ASPECTS OF THE STRUCTURE AND MECHANISM OF THE VOLTAGE‐DEPENDENT SODIUM CHANNEL *

  1980cited by this paper
• Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes.

  1980cited by this paper
• Potential-dependent interaction of toxin from venom of the scorpion Buthus eupeus with sodium channels in myelinated fibre: voltage clamp experiments.

  1980cited by this paper
• Further analysis of the mechanisms of action of batrachotoxin on the membrane of myelinated nerve.

  1979cited by this paper
• Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor.

  1979cited by this paper
• The calcium current and the activation of a slow potassium conductance in voltage‐clamped mouse neuroblastoma cells.

  1979cited by this paper
• Comparison of ionic selectivity of batrachotoxin-activated channels with different tetrodotoxin dissociation constants

  1979cited by this paper
• Properties of internally perfused, voltage-clamped, isolated nerve cell bodies

  1978cited by this paper
• Ionic currents in cultured mouse neuroblastoma cells under voltage‐clamp conditions.

  1978cited by this paper
• Molecular properties of the action potential Na+ ionophore in neuroblastoma cells. Interactions with neurotoxins.

  1978cited by this paper
• The temporal and steady‐state relationships between activation of the sodium conductance and movement of the gating particles in the squid giant axon.

  1976cited by this paper
• Scorpion neurotoxin - a presynaptic toxin which affects both Na+ and K+ channels in axons.

  1975cited by this paper
• Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venom.

  1975cited by this paper
• Chemicals as tools in the study of excitable membranes.

  1974cited by this paper
• Charge Movement Associated with the Opening and Closing of the Activation Gates of the Na Channels

  1974cited by this paper
• Effects of scorpion venom on squid axon membranes.

  1972cited by this paper
• [Effect of scorpion venom on ionic currents of the node of Ranvier. I. The permeabilities PNa and PK].

  1968cited by this paper
• [Effect of scorpion venom on ionic currents of the node of Ranvier. II. Incomplete sodium inactivation].

  1968cited by this paper

• Ts1 from the Brazilian scorpion Tityus serrulatus: A half‐century of studies on a multifunctional beta like‐toxin

  2018cites this paper
• Scorpion Venom as Therapeutic Agent-Current Perspective

  2016cites this paper
• A gamut of undiscovered electrophysiological effects produced by Tityus serrulatus toxin 1 on NaV-type isoforms.

  2015cites this paper
• Therapeutic use of scorpion venom

  2014cites this paper
• The Sophisticated Peptide Chemistry of Venomous Animals as a Source of Novel Insecticides Acting on Voltage-Gated Sodium Channels

  2012cites this paper
• Scorpion Venom and the Inflammatory Response

  2010cites this paper
• β-Scorpion Toxin Modifies Gating Transitions in All Four Voltage Sensors of the Sodium Channel

  2007cites this paper
• Novel paradigms on scorpion toxins that affects the activating mechanism of sodium channels.

  2007cites this paper
• Insect-selective spider toxins targeting voltage-gated sodium channels.

  2007cites this paper
• Voltage-gated ion channels and gating modifier toxins.

  2007cites this paper
• Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.

  2006cites this paper
• BjalphaIT: a novel scorpion alpha-toxin selective for insects--unique pharmacological tool.

  2005cites this paper
• Selective release of ATP from sympathetic nerves of rat vas deferens by the toxin TsTX‐I from Brazilian scorpion Tityus serrulatus

  2005influential citation
• Common Features in the Functional Surface of Scorpion β-Toxins and Elements That Confer Specificity for Insect and Mammalian Voltage-gated Sodium Channels*

  2005cites this paper
• Sodium channel inactivation: molecular determinants and modulation.

  2005cites this paper
• Effects of lead on voltage-gated sodium channels in rat hippocampal CA1 neurons.

  2005cites this paper
• Dopamine Release Evoked by Beta Scorpion Toxin, Tityus Gamma, in Prefrontal Cortical Slices is Mediated by Intracellular Calcium Stores

  2004cites this paper
• Isolation, molecular cloning and functional characterization of a novel beta-toxin from the Venezuelan scorpion, Tityus zulianus.

  2004cites this paper
• An 'Old World' scorpion beta-toxin that recognizes both insect and mammalian sodium channels.

  2003cites this paper
• Sodium Channel Toxins and Neurotransmitter Release

  2003cites this paper
• Lucifer Yellow Slows Voltage‐Gated Na+ Current Inactivation in a Light‐Dependent Manner in Mice

  2003cites this paper
• Release of gamma-[(3)H]aminobutyric acid in rat brain cortical slices by alpha-scorpion toxin.

  2002cites this paper
• Domain 2 of Drosophila Para Voltage-Gated Sodium Channel Confers Insect Properties to a Rat Brain Channel

  2002cites this paper
• Drug evolution: p-aminobenzoic acid as a building block.

  2002cites this paper
• Modulation of Na+-Channels by Neurotoxins Produces Different Effects on [3H]ACh Release with Mobilization of Distinct Ca2+-Channels

  2002cites this paper
• Spider neurotoxins block the beta scorpion toxin-induced calcium uptake in rat brain cortical synaptosomes.

  2001cites this paper
• A hyaluronidase from Tityus serrulatus scorpion venom: isolation, characterization and inhibition by flavonoids.

  2001cites this paper
• Beta-scorpion toxin induces the release of gamma-[3 H]aminobutyric acid in rat brain slices.

  2001cites this paper
• Neutralization of Gating Charges in Domain II of the Sodium Channel α Subunit Enhances Voltage-Sensor Trapping by a β-Scorpion Toxin

  2001cites this paper
• Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.

  2000cites this paper
• Sodium channels in central neurons of the tobacco budworm, Heliothis virescens: basic properties and modification by scorpion toxins.

  2000cites this paper
• Crystal structure of neurotoxin Ts1 from Tityus serrulatus provides insights into the specificity and toxicity of scorpion toxins.

  1999cites this paper
• Inactivated state dependence of sodium channel modulation by beta-scorpion toxin.

  1999cites this paper
• Antibodies against Tityus discrepans venom do not abolish the effect of Tityus serrulatus venom on the rat sodium and potassium channels.

  1999cites this paper
• Alpha- and beta-scorpion toxins evoke glutamate release from rat cortical synaptosomes with different effects on [Na+]i and [Ca2+]i.

  1998cites this paper
• Synergism between toxin-γ from Brazilian scorpion Tityus serrulatus and veratridine in chromaffin cells.

  1998cites this paper
• Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.

  1998cites this paper
• Effects of Tityus serrulatus scorpion toxin gamma on voltage-gated Na+ channels.

  1997cites this paper
• Refined electrophysiological analysis suggests that a depressant toxin is a sodium channel opener rather than a blocker.

  1997cites this paper
• Biochemical and histopathological alterations induced in rats by Tityus serrulatus scorpion venom and its major neurotoxin tityustoxin-I.

  1997cites this paper
• A new scorpion venom toxin paralytic to insects that affects Na+ channel activation. Purification, structure, antigenicity and mode of action.

  1996cites this paper
• Isolation and characterization of TsTX-V, a new neurotoxin from Tityus serrulatus scorpion venom which delays the inactivation of Na+ channels.

  1994cites this paper
• Poneratoxin, a new toxin from an ant venom, reveals an interconversion between two gating modes of the Na channels in frog skeletal muscle fibres

  1992cites this paper
• Effects of Buthus martensii (Karsch) scorpion venom on sodium currents in rat anterior pituitary (GH3/B6) cells.

  1992cites this paper
• Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes.

  1990cites this paper
• Modification of Na channel gating by an alpha scorpion toxin from Tityus serrulatus

  1989cites this paper
• Isolation and characterization of two toxins from the Mexican scorpion Centruroides limpidus limpidus Karsch.

  1988cites this paper
• Effects of New World scorpion toxins on single-channel and whole cell cardiac sodium currents.

  1988cites this paper
• Blocking of the squid axon K+ channel by noxiustoxin: a toxin from the venom of the scorpionCentruroides noxius

  1987cites this paper
• An integrated view of the molecular toxinology of sodium channel gating in excitable cells.

  1987cites this paper
• Burst kinetics of sodium channels which lack fast inactivation in mouse neuroblastoma cells.

  1987cites this paper
• Interactions of Scorpion Toxins with the Sodium Channel

  1986cites this paper
• Polypeptide Toxins as Tools to Study Voltage‐Sensitive Na+ Channels a

  1986cites this paper
• Effects of toxins VI and VII from the scorpionCentruroides sculpturatus on the Na currents of the frog node of Ranvier

  1986cites this paper
• Toxin γ of the scorpionTityus serrulatus modifies both activation and inactivation of sodium permeability of nerve membrane

  1986cites this paper
• Tetrodotoxin-sensitive and tetrodotoxin-resistant Na+ channels differ in their sensitivity to Cd2+ and Zn2+.

  1986cites this paper
• The interaction of polypeptide neurotoxins with tetrodotoxin-resistant Na+ channels in mammalian cardiac cells. Correlation with inotropic and arrhythmic effects.

  1986cites this paper
• Purification, sequence, and pharmacological properties of sea anemone toxins from Radianthus paumotensis. A new class of sea anemone toxins acting on the sodium channel.

  1985cites this paper
• The voltage-dependent Na+ channel of insect nervous system identified by receptor sites for tetrodotoxin, and scorpion and sea anemone toxins.

  1985cites this paper
• A monoclonal immunotoxin acting on the Na+ channel, with properties similar to those of a scorpion toxin.

  1985cites this paper