Enhanced Klebsiella pneumoniae Carbapenemase Expression from a Novel Tn4401 Deletion

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Antimicrobial Agents and Chemotherapy

• Publication date

  2017-04-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/AAC.00025-17PMID 28373185PMCID PMC5444142
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Overview of Changes to the Clinical and Laboratory Standards Institute Performance Standards for Antimicrobial Susceptibility Testing, M100, 31st Edition

  2021cited by this paper
• Genetic environment of the KPC gene in Acinetobacter baumannii ST2 clone from Puerto Rico and genomic insights into its drug resistance.

  2016cited by this paper
• Multicentre evaluation of a real-time PCR assay to detect genes encoding clinically relevant carbapenemases in cultured bacteria.

  2016cited by this paper
• The Role of Epidemic Resistance Plasmids and International High-Risk Clones in the Spread of Multidrug-Resistant Enterobacteriaceae

  2015cited by this paper
• Nested Russian Doll-Like Genetic Mobility Drives Rapid Dissemination of the Carbapenem Resistance Gene blaKPC

  2015cited by this paper
• KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel

  2015cited by this paper
• Molecular epidemiology of KPC-2-producing Enterobacteriaceae (non-Klebsiella pneumoniae) isolated from Brazil.

  2015cited by this paper
• Genomic Analysis of the Emergence and Rapid Global Dissemination of the Clonal Group 258 Klebsiella pneumoniae Pandemic

  2015cited by this paper
• Klebsiella pneumoniae Carbapenemase (KPC)-Producing K. pneumoniae at a Single Institution: Insights into Endemicity from Whole-Genome Sequencing

  2015cited by this paper
• Genomically Informed Surveillance for Carbapenem-Resistant Enterobacteriaceae in a Health Care System

  2015cited by this paper
• Antibiotic resistance threats in the United States: stepping back from the brink.

  2014cited by this paper
• Development and validation of a multiplex PCR assay for identification of the epidemic ST-258/512 KPC-producing Klebsiella pneumoniae clone.

  2014cited by this paper
• Mix and match of KPC-2 encoding plasmids in Enterobacteriaceae-comparative genomics.

  2014cited by this paper
• The Resistome of Pseudomonas aeruginosa in Relationship to Phenotypic Susceptibility

  2014cited by this paper
• Characterization of KPC-2-Producing Escherichia coli, Citrobacter freundii, Enterobacter cloacae, Enterobacter aerogenes, and Klebsiella oxytoca Isolates from a Chinese Hospital

  2014cited by this paper
• Modified Hodge Test versus Indirect Carbapenemase Test: Prospective Evaluation of a Phenotypic Assay for Detection of Klebsiella pneumoniae Carbapenemase (KPC) in Enterobacteriaceae

  2013cited by this paper
• Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.

  2013cited by this paper
• KPC-4 Is Encoded within a Truncated Tn4401 in an IncL/M Plasmid, pNE1280, Isolated from Enterobacter cloacae and Serratia marcescens

  2012influential reference
• Complete Nucleotide Sequences of blaKPC-4- and blaKPC-5-Harboring IncN and IncX Plasmids from Klebsiella pneumoniae Strains Isolated in New Jersey

  2012cited by this paper
• Role of ISKpn7 and Deletions in blaKPC Gene Expression

  2012influential reference
• blaKPC RNA Expression Correlates with Two Transcriptional Start Sites but Not Always with Gene Copy Number in Four Genera of Gram-Negative Pathogens

  2011cited by this paper
• Partial Excision of blaKPC from Tn4401 in Carbapenem-Resistant Klebsiella pneumoniae

  2011cited by this paper
• Functional Characterization of Tn4401, a Tn3-Based Transposon Involved in blaKPC Gene Mobilization

  2011cited by this paper
• Molecular Dissection of an Outbreak of Carbapenem-Resistant Enterobacteriaceae Reveals Intergenus KPC Carbapenemase Transmission through a Promiscuous Plasmid

  2011cited by this paper
• Multiplex PCR for detection of acquired carbapenemase genes.

  2011cited by this paper
• Emergence of bla KPC-3-Tn4401a associated with a pKPN3/4-like plasmid within ST384 and ST388 Klebsiella pneumoniae clones in Spain.

  2010cited by this paper
• Multiplex Real-Time PCR Assay for Detection and Classification of Klebsiella pneumoniae Carbapenemase Gene (bla KPC) Variants

  2010cited by this paper
• Worldwide Diversity of Klebsiella pneumoniae That Produce β-Lactamase blaKPC-2 Gene

  2010cited by this paper
• Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae.

  2010cited by this paper
• Genetic Factors Associated with Elevated Carbapenem Resistance in KPC-Producing Klebsiella pneumoniae

  2010cited by this paper
• Genetic Organization of Transposase Regions Surrounding blaKPC Carbapenemase Genes on Plasmids from Klebsiella Strains Isolated in a New York City Hospital

  2009cited by this paper
• Novel Genetic Environment of the Carbapenem-Hydrolyzing β-Lactamase KPC-2 among Enterobacteriaceae in China

  2009cited by this paper
• Molecular Epidemiology of KPC-Producing Klebsiella pneumoniae Isolates in the United States: Clonal Expansion of Multilocus Sequence Type 258

  2009cited by this paper
• Genetic Structures at the Origin of Acquisition of the β-Lactamase blaKPC Gene

  2008influential reference
• Carbapenemases: the versatile beta-lactamases.

  2007cited by this paper
• Carbapenemases: the Versatile β-Lactamases

  2007cited by this paper
• Identification of plasmids by PCR-based replicon typing.

  2005cited by this paper
• Measuring beta-galactosidase activity in bacteria: cell growth, permeabilization, and enzyme assays in 96-well arrays.

  2002cited by this paper
• Performance standards for antimicrobial susceptibility testing

  2001cited by this paper
• Improved single and multicopy lac-based cloning vectors for protein and operon fusions.

  1987cited by this paper

• 'Omics technologies for the elucidation of the molecular mechanisms related to carbapenem-resistant and extended spectrum β-lactamase-producing Klebsiellapneumoniae.

  2025cites this paper
• Molecular characterization of a clinical ST145 Klebsiella oxytoca strain co-producing KPC-2 and IMP-96 carbapenemases

  2025cites this paper
• Potential role of avibactam in restoring susceptibility in Escherichia coli with two copies of blaKPC-3 and PBP3 mutations

  2025influential citation
• Characterization of a blaKPC-3-carrying plasmid in a clinical isolate of Klebsiella pneumoniae belonging to the emerging successful clone ST147

  2025cites this paper
• Evolution of ceftazidime–avibactam resistance driven by mutations in double-copy blaKPC-2 to blaKPC-189 during treatment of ST11 carbapenem-resistant Klebsiella pneumoniae

  2024influential citation
• Developing a framework for tracking antimicrobial resistance gene movement in a persistent environmental reservoir

  2024cites this paper
• Characterization of KPC-type drug resistance in bacteria

  2024cites this paper
• A Review of Carbapenem Resistance in Enterobacterales and Its Detection Techniques

  2023cites this paper
• Predominant transmission of KPC-2 carbapenemase in Germany by a unique IncN plasmid variant harboring a novel non-transposable element (NTE KPC -Y)

  2023cites this paper
• Plasmid genomic epidemiology of blaKPC carbapenemase-producing Enterobacterales in Canada, 2010–2021

  2023cites this paper
• Klebsiella pneumoniae carbapenemase variants: the new threat to global public health

  2023cites this paper
• Transiently silent acquired antimicrobial resistance: an emerging challenge in susceptibility testing

  2023cites this paper
• KPC-3-, GES-5-, and VIM-1-Producing Enterobacterales Isolated from Urban Ponds

  2022cites this paper
• A Comprehensive Genomic Analysis of the Emergent Klebsiella pneumoniae ST16 Lineage: Virulence, Antimicrobial Resistance and a Comparison with the Clinically Relevant ST11 Strain

  2022cites this paper
• Global spread of carbapenem-resistant Enterobacteriaceae: Epidemiological features, resistance mechanisms, detection and therapy.

  2022cites this paper
• Proteus mirabilis resistant to carbapenems isolated from a patient with a venous leg ulcer: a case report.

  2022cites this paper
• Description of a new non-Tn4401 element (NTEKPC-IIe) harbored on IncQ plasmid in Citrobacter werkmanii from recreational coastal water.

  2022cites this paper
• Epidemic HI2 Plasmids Mobilising the Carbapenemase Gene blaIMP-4 in Australian Clinical Samples Identified in Multiple Sublineages of Escherichia coli ST216 Colonising Silver Gulls

  2021cites this paper
• Replicative transposition contributes to the evolution and dissemination of KPC-2-producing plasmid in Enterobacterales

  2021cites this paper
• Molecular Analysis of blaKPC-2-Harboring Plasmids: Tn4401a Interplasmid Transposition and Tn4401a-Carrying ColRNAI Plasmid Mobilization from Klebsiella pneumoniae to Citrobacter europaeus and Morganella morganii in a Single Patient

  2021cites this paper
• Within patient genetic diversity of blaKPC harboring Klebsiellapneumoniae in a Colombian hospital and identification of a new NTEKPC platform

  2021cites this paper
• Pitfalls in genotypic antimicrobial susceptibility testing caused by low expression of blaKPC in Escherichia coli.

  2021cites this paper
• Mobile Carbapenemase Genes in Pseudomonas aeruginosa

  2021cites this paper
• Molecular Epidemiology of Carbapenemases in Enterobacteriales from Humans, Animals, Food and the Environment

  2020cites this paper
• Genomic Epidemiology of Complex, Multispecies, Plasmid-Borne blaKPC Carbapenemase in Enterobacterales in the United Kingdom from 2009 to 2014

  2020cites this paper
• Mobile genetic elements associated with carbapenemase genes in South American Enterobacterales

  2020cites this paper
• Update on Susceptibility Testing: Genotypic and Phenotypic Methods.

  2020cites this paper
• Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in Enterobacteriaceae: a Systematic Review of Current Reports

  2020influential citation
• Genomic epidemiology of complex, multi-species, plasmid-borne bla KPC 1 carbapenemase in Enterobacterales in the UK, 2009-2014

  2020cites this paper
• Genomic epidemiology of a complex, multi-species plasmid-borne blaKPC carbapenemase outbreak in Enterobacterales in the UK, 2009-2014

  2019cites this paper
• Validating the AMRFinder Tool and Resistance Gene Database by Using Antimicrobial Resistance Genotype-Phenotype Correlations in a Collection of Isolates

  2019cites this paper
• Assessing genetic diversity and similarity of 435 KPC-carrying plasmids

  2019cites this paper
• Reduced ceftazidime and ertapenem susceptibility due to production of OXA-2 in Klebsiella pneumoniae ST258.

  2019cites this paper
• Using the NCBI AMRFinder Tool to Determine Antimicrobial Resistance Genotype-Phenotype Correlations Within a Collection of NARMS Isolates

  2019cites this paper
• Genetic Factors Associated with Enhanced blaKPC Expression in Tn3/Tn4401 Chimeras

  2019cites this paper
• Pandemic spread of blaKPC-2 among Klebsiella pneumoniae ST11 in China is associated with horizontal transfer mediated by IncFII-like plasmids.

  2019cites this paper
• Comparative Analysis of blaKPC Expression in Tn4401 Transposons and the Tn3-Tn4401 Chimera

  2019influential citation
• Carbapenem-Resistant Klebsiella pneumoniae: Microbiology Key Points for Clinical Practice

  2019cites this paper
• Whole-genome sequencing resolves a polyclonal outbreak by extended-spectrum beta-lactam and carbapenem-resistant Klebsiella pneumoniae in a Portuguese tertiary-care hospital

  2019cites this paper
• Genome plasticity favours double chromosomal Tn4401b-blaKPC-2 transposon insertion in the Pseudomonas aeruginosa ST235 clone

  2019cites this paper
• KPC-2 producing ST101 Klebsiella pneumoniae from bloodstream infection in India.

  2018cites this paper
• Klebsiella pneumoniae Carbapenemase Producers in South Korea between 2013 and 2015

  2018influential citation
• Genetic Platforms of blaCTX-M in Carbapenemase-Producing Strains of K. pneumoniae Isolated in Chile

  2018cites this paper
• Enterobacter cloacae complex ST-171 Isolates Expressing KPC-4 Carbapenemase Recovered from Canine Patients in Ohio, USA

  2018cites this paper
• The efflux pump inhibitor phenylalanine-arginine β-naphthylamide (PAβN) increases resistance to carbapenems in Chilean clinical isolates of KPC-producing Klebsiella pneumoniae.

  2018cites this paper
• Transcriptional Landscape of a blaKPC-2 Plasmid and Response to Imipenem Exposure in Escherichia coli TOP10

  2018cites this paper
• Comparative genomics analysis of pTEM-2262, an MDR plasmid from Citrobacter freundii, harboring two unclassified replicons.

  2018cites this paper
• Enterobacter cloacae complex ST-171 Isolates Expressing KPC-4 Carbapenemase Recovered 1 from Canine Patients in Ohio , USA 2 3

  2018cites this paper
• TETyper: a bioinformatic pipeline for classifying variation and genetic contexts of transposable elements from short-read whole-genome sequencing data

  2018cites this paper
• A Large, Refractory Nosocomial Outbreak of Klebsiella pneumoniae Carbapenemase-Producing Escherichia coli Demonstrates Carbapenemase Gene Outbreaks Involving Sink Sites Require Novel Approaches to Infection Control

  2018cites this paper
• Enterobacter cloacae Complex Sequence Type 171 Isolates Expressing KPC-4 Carbapenemase Recovered from Canine Patients in Ohio

  2018cites this paper
• Insights into a novel Tn4401 deletion (Tn4401i) in a multidrug-resistant Klebsiella pneumoniae clinical strain belonging to the high-risk clonal group 258 producing KPC-2.

  2018cites this paper
• Mobile Genetic Elements Associated with Antimicrobial Resistance

  2018cites this paper
• [KPC: Klebsiella pneumoniae carbapenemase, main carbapenemase in Enterobacteriaceae].

  2017cites this paper
• IncX3 plasmid harboring a non-Tn4401 genetic element (NTEKPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258.

  2017cites this paper