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Concentrated Extract of Green Tea Polyphenols Enhances the Toxicity of the Elderberry Lectin Nigrin b to Mice

P. Jiménez,Patricia Cabrero,J. Tejero,M. Gayoso,M. Garrosa,D. Córdoba-Díaz,M. Córdoba-Díaz,T. Girbés

Published 2014 in Food and Nutrition Sciences

ABSTRACT

The effect of the administration of large amounts of green tea polyphenols is a matter of controversy. We explored whether a polyphenol mixture from a concentrated green tea extract (Polyphenon 60) could alter the effects on mice of the type 2 (two chains) ribosome-inactivating protein nigrin b isolated from Sambucus nigra L. Nigrin b triggers specific reversible toxic effects on the mouse intestines featured by apoptosis of mice Lieberkuhn crypt cells upon parenteral administration of sub-lethal amounts. Independent administration to mice of 30 mg/kg body weight of Polyphenon 60 by oral gavage or 10 mg/kg body weight of nigrin b administered via the intraperitoneal route (i.p.) did not affect survival. In contrast, the simultaneous treatment greatly enhanced nigrin b toxicity leading to the death of some animals. The histological analysis revealed that the most serious injury was inflicted on the small intestine crypts, which disappeared, and on the liver, which evidenced hepatotoxicity showing haemorrhagic areas. These findings raise concerns about the abuse of high concentrations of green tea polyphenols especially when the intestinal mucosa is damaged, for instance by toxins or therapeutic drugs.

PUBLICATION RECORD

  • Publication year

    2014

  • Venue

    Food and Nutrition Sciences

  • Publication date

    2014-02-26

  • Fields of study

    Biology, Medicine, Environmental Science

  • Identifiers
    DOI 10.4236/FNS.2014.55055
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

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