A high-throughput robotic sample preparation system and HPLC-MS/MS for measuring urinary anatabine, anabasine, nicotine and major nicotine metabolites.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Clinica chimica acta; international journal of clinical chemistry

• Publication date

  2014-09-25

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.cca.2014.06.012PMID 24968308PMCID PMC4516125
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Validation of a LC-MS/MS Method for Quantifying Urinary Nicotine, Six Nicotine Metabolites and the Minor Tobacco Alkaloids—Anatabine and Anabasine—in Smokers' Urine

  2014influential reference
• U.S. Department of Health & Human Services

  2014cited by this paper
• Exposure to Secondhand Smoke Outside of a Bar and a Restaurant and Tobacco Exposure Biomarkers in Nonsmokers

  2012cited by this paper
• Simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine, norcotinine and mecamylamine in human urine by liquid chromatography-tandem mass spectrometry.

  2012cited by this paper
• Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS).

  2012cited by this paper
• Exposure to different sources of second-hand smoke during pregnancy and its effect on urinary cotinine and tobacco-specific nitrosamine (NNAL) concentrations

  2012cited by this paper
• Exposure of flight attendants to pyrethroid insecticides on commercial flights: urinary metabolite levels and implications.

  2012cited by this paper
• A novel validated procedure for the determination of nicotine, eight nicotine metabolites and two minor tobacco alkaloids in human plasma or urine by solid-phase extraction coupled with liquid chromatography-electrospray ionization-tandem mass spectrometry.

  2010cited by this paper
• ICH Harmonised Tripartite Guideline

  2009cited by this paper
• Multi‐rule quality control for the age‐related eye disease study

  2008cited by this paper
• Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid chromatography-tandem mass spectrometry.

  2008cited by this paper
• The Chemical Components of Tobacco and Tobacco Smoke

  2008cited by this paper
• Simultaneous determination of multiple drugs of abuse and relevant metabolites in urine by LC-MS-MS.

  2007cited by this paper
• An improved approach for accurate quantitation of benzene, toluene, ethylbenzene, xylene, and styrene in blood.

  2006cited by this paper
• Metabolism and Disposition Kinetics of Nicotine

  2005influential reference
• Human Biomonitoring of Environmental Chemicals

  2004cited by this paper
• Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography-tandem mass spectrometry.

  2004cited by this paper
• Ionization enhancement in atmospheric pressure chemical ionization and suppression in electrospray ionization between target drugs and stable-isotope-labeled internal standards in quantitative liquid chromatography/tandem mass spectrometry.

  2003cited by this paper
• Recent extraction techniques for natural products: microwave-assisted extraction and pressurised solvent extraction.

  2002cited by this paper
• Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy.

  2002influential reference
• Acute effects of passive smoking on the coronary circulation in healthy young adults.

  2001cited by this paper
• Matrix effect in quantitative LC/MS/MS analyses of biological fluids: a method for determination of finasteride in human plasma at picogram per milliliter concentrations.

  1998cited by this paper
• Development and validation of sensitive method for determination of serum cotinine in smokers and nonsmokers by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry.

  1997cited by this paper
• Protection of Human Subjects

  1994cited by this paper
• Universal sample enrichment technique for organochlorine pesticides in environmental and biological samples using a redesigned simultaneous steam distillation-solvent extraction apparatus

  1993cited by this paper
• Association between exposure to environmental tobacco smoke and exacerbations of asthma in children.

  1993cited by this paper
• ANALYTICAL-SCALE SUPERCRITICAL FLUID EXTRACTION

  1990cited by this paper
• Quality Assurance of Chemical Measurements

  1984cited by this paper
• Cigarette smoke-induced DNA damage and lung cancer risks

  1980cited by this paper

• Simultaneous quantification of fourteen urinary tobacco biomarkers via UHPLC-Q-Orbitrap HRMS and isotope dilution.

  2026cites this paper
• Anatabine: a Substitute for the Medicinal Activity of Nicotine.

  2026cites this paper
• A Gold Nanoparticles-Based “Off–On” Sensor for Nicotine Determination in Tobacco Products

  2025cites this paper
• Nicotine and Toxicant Exposure among Individuals using both Combustible Cigarettes and E-cigarettes Based on Level of Product Use

  2025cites this paper
• ENDS use and nicotine exposure among adults who use ENDS alone or with cigarettes: The PATH Study 2013-2019.

  2025cites this paper
• Tobacco Smoke Exposure Biomarker Profiles and Healthcare Utilization Patterns Among U.S. Children

  2025influential citation
• Altered Regional Brain Activity Underlying the Higher Postoperative Analgesic Requirements in Abstinent Smokers: A Prospective Cohort Study

  2025cites this paper
• An automated liquid-liquid extraction platform for high-throughput sample preparation of urinary phthalate metabolites in human biomonitoring.

  2025cites this paper
• Computer Vision-Assisted Robotized Sampling of Volatile Organic Compounds

  2024cites this paper
• Biomarkers of Exposure to Nicotine and Selected Toxicants in Individuals Who Use Alternative Tobacco Products Sold in Japan and Canada from 2018 to 2019

  2024cites this paper
• Novel proposed cutoff values for anatabine and anabasine in differentiating smokers from non-smokers.

  2023cites this paper
• Quantitation of Ten Urinary Nicotine Metabolites, Including 4-Hydroxy-4-(3-pyridyl) Butanoic Acid, a Product of Nicotine 2'-Oxidation, and CYP2A6 Activity in Japanese Americans, Native Hawaiians, and Whites.

  2023cites this paper
• Distinguishing Exposure to Secondhand and Thirdhand Tobacco Smoke among U.S. Children Using Machine Learning: NHANES 2013-2016.

  2023cites this paper
• Improving Wastewater-Based Tobacco Use Estimates Using Anabasine.

  2023cites this paper
• Influence of half-life and smoking/nonsmoking ratio on biomarker consistency between Waves 1 and 2 of the Population Assessment of Tobacco and Health Study.

  2023cites this paper
• Urinary Nicotine Metabolites and Self-Reported Tobacco Use Among Adults in the Population Assessment of Tobacco and Health (PATH) Study, 2013-2014.

  2022cites this paper
• Application of HPLC-QQQ-MS/MS and New RP-HPLC-DAD System Utilizing the Chaotropic Effect for Determination of Nicotine and Its Major Metabolites Cotinine, and trans-3′-Hydroxycotinine in Human Plasma Samples

  2022cites this paper
• Simultaneous quantification of urinary tobacco and marijuana metabolites using solid-supported liquid-liquid extraction coupled with liquid chromatography tandem mass spectrometry.

  2022cites this paper
• Minor Tobacco Alkaloids as Biomarkers to Distinguish Combusted Tobacco Use From Electronic Nicotine Delivery Systems Use. Two New Analytical Methods

  2022cites this paper
• Anabasine and Anatabine Exposure Attributable to Cigarette Smoking: National Health and Nutrition Examination Survey (NHANES) 2013–2014

  2022cites this paper
• Nicotine Exposure in the U.S. Population: Total Urinary Nicotine Biomarkers in NHANES 2015–2016

  2022cites this paper
• Sensitive Quantification of Nicotine in Bronchoalveolar Lavage Fluid by Acetone Precipitation Combined With Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry

  2021cites this paper
• Automated Solid Phase Extraction and Polarity-Switching Tandem Mass Spectrometry Technique for High Throughput Analysis of Urine Biomarkers for 14 Tobacco-related Compounds

  2021cites this paper
• Method Development and Validation of Anabasine and Nornicotine in Human Plasma by LC-MS/MS

  2021cites this paper
• Biochemistry of nicotine metabolism and its relevance to lung cancer

  2021cites this paper
• Urinary Cotinine and Cotinine + Trans-3′-Hydroxycotinine (TNE-2) Cut-points for Distinguishing Tobacco Use from Nonuse in the United States: PATH Study (2013–2014)

  2021cites this paper
• Exposure to Nicotine and Toxicants Among Dual Users of Tobacco Cigarettes and E-Cigarettes: Population Assessment of Tobacco and Health (PATH) Study, 2013-2014.

  2021cites this paper
• Acrolein and other toxicant exposures in relation to cardiovascular disease among marijuana and tobacco smokers in a longitudinal cohort of HIV-positive and negative adults

  2021cites this paper
• Sexual identity differences in biomarkers of tobacco exposure among women in a national sample.

  2021cites this paper
• Challenges associated with quantification of selected urinary biomarkers of exposure to tobacco products.

  2020cites this paper
• Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study

  2020cites this paper
• Biomarkers of Exposure among Adult Smokeless Tobacco Users in the Population Assessment of Tobacco and Health Study (Wave 1, 2013–2014)

  2020cites this paper
• Correlation between biomarkers of exposure, effect and potential harm in the urine of electronic cigarette users

  2020cites this paper
• The Impact of Exclusive Use of Very Low Nicotine Cigarettes on Compensatory Smoking: An Inpatient Crossover Clinical Trial

  2020cites this paper
• Tobacco-Specific Nitrosamines (NNAL, NNN, NAT, and NAB) Exposures in the US Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).

  2020cites this paper
• Emerging Chemicals of Health Concern in Electronic Nicotine Delivery Systems

  2020cites this paper
• Biomarkers of Exposure among USA Adult Hookah Users: Results from Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study (2013–2014)

  2020cites this paper
• Urinary Acrylonitrile Metabolite Concentrations Before and after Smoked, Vaporized, and Oral Cannabis in Frequent and Occasional Cannabis Users

  2020cites this paper
• Long-term trends in tobacco use assessed by wastewater-based epidemiology and its relationship with consumption of nicotine containing products.

  2020cites this paper
• Differences in Exposure to Nicotine, Tobacco-Specific Nitrosamines, and Volatile Organic Compounds among Electronic Cigarette Users, Tobacco Smokers, and Dual Users from Three Countries

  2020cites this paper
• Development and Validation of a Quantification Method of Cotinine in Urine Using Two Innovative Technologies: Supported Liquid Extraction and QDa Detection

  2020cites this paper
• A Simple and High-throughput LC-MS/MS Method for Simultaneous Measurement of Nicotine, Cotinine, 3-OH cotinine, Nornicotine, and Anabasine in Urine and its Application in the General Korean Population.

  2020cites this paper
• Waterpipe tobacco smoke: Characterization of toxicants and exposure biomarkers in a cross-sectional study of waterpipe employees.

  2019cites this paper
• Concurrent Quantification of Emerging Chemicals of Health Concern in e-Cigarette Liquids by High-Performance Liquid Chromatography–Tandem Mass Spectrometry

  2019cites this paper
• Nicotine and Toxicant Exposure among Concurrent Users ("Co-users") of Tobacco and Cannabis.

  2019cites this paper
• A Laboratory-Built Fully Automated Ultrasonication Robot for Filamentous Fungi Homogenization

  2019cites this paper
• Secondhand marijuana smoke (SHMS): Exposure occurrence, biological analysis and potential health effects

  2019cites this paper
• Tobacco Use Classification by Inexpensive Urinary Cotinine Immunoassay Test Strips.

  2018cites this paper
• Simultaneous determination of tobacco minor alkaloids and tobacco-specific nitrosamines in mainstream smoke by dispersive solid-phase extraction coupled with ultra-performance liquid chromatography/tandem orbitrap mass spectrometry.

  2018cites this paper
• Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine

  2018cites this paper
• Decreased pain tolerance before surgery and increased postoperative narcotic requirements in abstinent tobacco smokers.

  2018cites this paper
• Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes

  2018cites this paper
• in long-term e-cigarette and replacement therapy

  2017cites this paper
• Measurement of urinary Benzo[a]pyrene tetrols and their relationship to other polycyclic aromatic hydrocarbon metabolites and cotinine in humans.

  2017cites this paper
• Nicotine , carcinogen and toxicant exposure in long-term e-cigarette and nicotine replacement therapy users : a cross-sectional study Running title : e-cigarettes and toxicant exposure

  2017cites this paper
• Nicotine, Carcinogen, and Toxin Exposure in Long-Term E-Cigarette and Nicotine Replacement Therapy Users

  2017cites this paper
• Temporal Trends of Secondhand Smoke Exposure: Nonsmoking Workers in the United States (NHANES 2001–2010)

  2016cites this paper
• Determination of salivary cotinine through solid phase extraction using a bead-injection lab-on-valve approach hyphenated to hydrophilic interaction liquid chromatography.

  2016cites this paper
• Quantitation of the Minor Tobacco Alkaloids Nornicotine, Anatabine, and Anabasine in Smokers' Urine by High Throughput Liquid Chromatography-Mass Spectrometry.

  2016cites this paper
• Electrodeposition of Au nanoparticles on poly(diallyldimethylammonium chloride) functionalized reduced graphene oxide sheets for voltammetric determination of nicotine in tobacco products and anti-smoking pharmaceuticals

  2016cites this paper
• Assessing exposure to tobacco-specific carcinogen NNK using its urinary metabolite NNAL measured in US population: 2011–2012

  2016cites this paper
• Urinary concentrations of PAH and VOC metabolites in marijuana users.

  2016cites this paper
• Analysis of Cannabinoids and Their Metabolites in Human Urine.

  2015cites this paper
• , carcinogen and toxicant exposure in long-term e-cigarette and nicotine replacement therapy

  year unknowncites this paper