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Psychiatric disorders associated with Cushing's syndrome.

A. Bratek,A. Koźmin-Burzyńska,E. Górniak,K. Krysta

Published 2015 in Psychiatria Danubina

ABSTRACT

BACKGROUND Cushing's syndrome is the term used to describe a set of symptoms associated with hypercortisolism, which in most cases is caused by hypophysial microadenoma over-secreting adrenocorticotropic hormone. This endocrine disorder is often associated with psychiatric comorbidities. The most important include mood disorders, psychotic disorders, cognitive dysfunctions and anxiety disorders. SUBJECT AND METHODS The aim of this article was to review the prevalence, symptoms and consequences of psychiatric disorders in the course of Cushing's syndrome. We therefore performed a literature search using the following keywords: Cushing's syndrome and psychosis, Cushing's syndrome and mental disorders, Cushing's syndrome and depression, Cushing's syndrome and anxiety. RESULTS The most prevalent psychiatric comorbidity of Cushing's syndrome is depression. Psychiatric manifestations can precede the onset of full-blown Cushing's syndrome and therefore be misdiagnosed. Despite the fact that treatment of the underlying endocrine disease in most cases alleviates psychiatric symptoms, the loss of brain volume persists. CONCLUSIONS It is important to be alert to the symptoms of hypercortisolism in psychiatric patients to avoid misdiagnosis and enable them receiving adequate treatment.

PUBLICATION RECORD

  • Publication year

    2015

  • Venue

    Psychiatria Danubina

  • Publication date

    2015-09-01

  • Fields of study

    Medicine, Psychology

  • Identifiers
    PMID 26417792
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar, PubMed

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