Phosphatase protein homologue to tensin expression and phosphatidylinositol-3 phosphate kinase mutations in colorectal cancer.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cancer Research

• Publication date

  2005-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1158/0008-5472.CAN-05-2780PMID 16322273
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Colorectal cancer: Mutations in a signalling pathway

  2005cited by this paper
• PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.

  2005cited by this paper
• Different Genetic Features Associated with Colon and Rectal Carcinogenesis

  2004cited by this paper
• High Frequency of Mutations of the PIK3CA Gene in Human Cancers

  2004cited by this paper
• PI3K-Akt pathway: Its functions and alterations in human cancer

  2004cited by this paper

• PTEN as a Novel Diagnostic and Prognostic Biomarker of Head and Neck Squamous Cell Carcinoma

  2024cites this paper
• BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21CIP1/WAF1

  2024cites this paper
• MDM2 inhibition is synthetic lethal with PTEN loss in colorectal cancer cells via the p53-dependent mechanism

  2023cites this paper
• A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3'-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer.

  2021cites this paper
• PTEN Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?

  2020cites this paper
• Treatment of Disfiguring Cutaneous Lesions in Neurofibromatosis-1 with Everolimus: A Phase II, Open-Label, Single-Arm Trial

  2018cites this paper
• BRG1 is correlated with poor prognosis in colorectal cancer.

  2017cites this paper
• A Randomized, Phase II Trial of Cetuximab With or Without PX-866, an Irreversible Oral Phosphatidylinositol 3-Kinase Inhibitor, in Patients With Metastatic Colorectal Carcinoma.

  2016cites this paper
• PTEN – clinical significance in colorectal cancer

  2016cites this paper
• Whole exome sequencing and single nucleotide polymorphism array analyses to identify germline alterations in genes associated with testosterone metabolism in a patient with androgen insensitivity syndrome and early-onset colorectal cancer

  2016cites this paper
• Antitumor effect of manumycin on colorectal cancer cells by increasing the reactive oxygen species production and blocking PI3K-AKT pathway

  2016influential citation
• Targeted Therapies For Intestinal Tumorigenesis

  2015cites this paper
• PTEN: Multiple Functions in Human Malignant Tumors

  2015cites this paper
• Phase I study of everolimus, cetuximab and irinotecan as second-line therapy in metastatic colorectal cancer.

  2015cites this paper
• Association of genetic polymorphisms in PTEN and additional interaction with alcohol consumption and smoking on colorectal cancer in Chinese population.

  2015cites this paper
• Intestinal Tumorigenesis

  2015cites this paper
• Predictive Biomarkers to Anti-EGFR Inhibitors Treatment in the Management of Metastatic Colorectal Cancer

  2014cites this paper
• Mutational profiling of kinases in glioblastoma

  2014cites this paper
• MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer

  2014cites this paper
• Sialidases and cancer: human sialidase neu3 enhances egfr activation in colorectal cancer

  2014cites this paper
• Predictive biomarkers to anti-EGF receptor inhibitors in the treatment of metastatic colorectal cancer

  2014cites this paper
• Functions and Regulation of the PTEN Gene in Colorectal Cancer

  2013cites this paper
• Phase II Study of Everolimus in Patients with Metastatic Colorectal Adenocarcinoma Previously Treated with Bevacizumab-, Fluoropyrimidine-, Oxaliplatin-, and Irinotecan-Based Regimens

  2013cites this paper
• PIK3CA and PTEN Gene and Exon Mutation-Specific Clinicopathologic and Molecular Associations in Colorectal Cancer

  2013cites this paper
• Imaging , Diagnosis , Prognosis PIK 3 CA and PTEN Gene and Exon Mutation-Speci fi c Clinicopathologic and Molecular Associations in Colorectal Cancer

  2013cites this paper
• mTOR signaling pathway and mTOR inhibitors in cancer therapy.

  2012cites this paper
• Phase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum

  2012cites this paper
• PTEN in colorectal cancer: a report on two Cowden syndrome patients

  2012cites this paper
• PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer.

  2012cites this paper
• Mammalian target of rapamycin expression in poorly differentiated endocrine carcinoma: clinical and therapeutic future challenges

  2011cites this paper
• KRAS and BRAF mutation analysis can be reliably performed on aspirated cytological specimens of metastatic colorectal carcinoma

  2011cites this paper
• Development of molecular biomarkers in individualized treatment of colorectal cancer.

  2011cites this paper
• Mechanism of EGER-related cancer drug resistance

  2011cites this paper
• PIK3CA mutations and amplification in endometrioid endometrial carcinomas: relation to other genetic defects and clinicopathologic status of the tumors.

  2011cites this paper
• PI-3-Kinase inhibitors in colorectal cancer.

  2011cites this paper
• Intestinal epithelial-specific PTEN inactivation results in tumor formation.

  2011cites this paper
• Loss of PTEN Expression in Neuroendocrine Pancreatic Tumors

  2011cites this paper
• Microsatellite instability in colorectal cancer—the stable evidence

  2010cites this paper
• Regulation of PTEN expression by the SWI/SNF chromatin-remodelling protein BRG1 in human colorectal carcinoma cells

  2010cites this paper
• Investigating the roles of RKIP and p53 in colorectal carcinoma

  2010cites this paper
• Thymidylate synthase expression and mismatch repair protein expression in colorectal cancer

  2010cites this paper
• Concomitant PI3K–AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis

  2009cites this paper
• Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant

  2009cites this paper
• Mutations and Response to Epidermal Growth Factor Receptor Inhibitors

  2009cites this paper
• Biomarkers Predicting Clinical Outcome of Epidermal Growth Factor Receptor–Targeted Therapy in Metastatic Colorectal Cancer

  2009cites this paper
• PIK3CA Gene Alterations in Human Cancers

  2009cites this paper
• PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab.

  2008cites this paper
• PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters

  2008cites this paper
• Mutations in the RAS‐MAPK, PI(3)K (phosphatidylinositol‐3‐OH kinase) signaling network correlate with poor survival in a population‐based series of colon cancers

  2008cites this paper
• Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival

  2008cites this paper
• AKT1E17K in human solid tumours

  2008cites this paper
• Biochemical and biological characterization of tumor-associated mutations of p110alpha.

  2008cites this paper
• PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients

  2007cites this paper
• Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population

  2007cites this paper
• CANCER DRUG DISCOVERY AND DEVELOPMENT

  2007cites this paper
• Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma

  2007cites this paper
• Oncotargets and Therapy Dovepress Open Access to Scientific and Medical Research Open Access Full Text Article Dovepress Multiple Roles and Therapeutic Implications of Akt Signaling in Cancer

  year unknowncites this paper