Indoor Volatile Organic Compounds and Chemical Sensitivity Reactions

Studies of unexplained symptoms observed in chemically sensitive subjects have increased the awareness of the relationship between neurological and immunological diseases due to exposure to volatile organic compounds (VOCs). However, there is no direct evidence that links exposure to low doses of VOCs and neurological and immunological dysfunction. We review animal model data to clarify the role of VOCs in neuroimmune interactions and discuss our recent studies that show a relationship between chronic exposure of C3H mice to low levels of formaldehyde and the induction of neural and immune dysfunction. We also consider the possible mechanisms by which VOC exposure can induce the symptoms presenting in patients with a multiple chemical sensitivity.

• Publication year

  2013

• Venue

  Clinical and Developmental Immunology

• Publication date

  2013-10-21

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1155/2013/623812PMID 24228055PMCID 3818819
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Olfactory Cortex

  2015cited by this paper
• Investigation of air pollution in large-scale buildings and of employees' personal exposure level

  2007cited by this paper
• Effects of low-level formaldehyde exposure on synaptic plasticity-related gene expression in the hippocampus of immunized mice.

  2007cited by this paper
• Effects of Subchronic Exposure to Low Concentrations of Toluene on the Hypothalamo-Pituitary-Adrenal Gland Axis of Female Mice

  2006cited by this paper
• Inhalation of Low-Level Formaldehyde Increases the Bcl-2/Bax Expression Ratio in the Hippocampus of Immunologically Sensitized Mice

  2006cited by this paper
• Hypothalamo-pituitary-adrenal gland axis in mice inhaling toluene prior to low-level long-term exposure to formaldehyde.

  2005cited by this paper
• Differential immunogenic and neurogenic inflammatory responses in an allergic mouse model exposed to low levels of formaldehyde.

  2004cited by this paper
• Inhalation of Low-Level Formaldehyde Enhances Nerve Growth Factor Production in the Hippocampus of Mice

  2004cited by this paper
• Nerve growth factor and substance P regulation in nasal sensory neurons after toluene diisocyanate exposure.

  2004cited by this paper
• Effect of prolonged exposure to low concentrations of formaldehyde on the corticotropin releasing hormone neurons in the hypothalamus and adrenocorticotropic hormone cells in the pituitary gland in female mice.

  2004cited by this paper
• Long-term exposure to low levels of formaldehyde increases the number of tyrosine hydroxylase-immunopositive periglomerular cells in mouse main olfactory bulb.

  2004cited by this paper
• A review of a two-phase population study of multiple chemical sensitivities.

  2003cited by this paper
• Central neurological abnormalities and multiple chemical sensitivity caused by chronic toluene exposure.

  2003cited by this paper
• Multiple feedback mechanisms activating corticotropin-releasing hormone system in the brain during stress.

  2002cited by this paper
• Cellular activation and neuronal transport of intranasally instilled benzo(a)pyrene in the olfactory system of rats.

  2002cited by this paper
• NMDA sensitization and stimulation by peroxynitrite, nitric oxide, and organic solvents as the mechanism of chemical sensitivity in multiple chemical sensitivity

  2002cited by this paper
• Does the Kindling Model of Epilepsy Contribute to Our Understanding of Multiple Chemical Sensitivity?

  2001cited by this paper
• Neurogenic inflammation in the airways.

  2001cited by this paper
• Blocking NMDA receptors in the hippocampal dentate gyrus with AP5 produces analgesia in the formalin pain test.

  2001cited by this paper
• The effects of restraint stress on the neuropathogenesis of Theiler's virus infection: I. Acute disease.

  2001cited by this paper
• Repeated Formaldehyde Effects in an Animal Model for Multiple Chemical Sensitivity

  2001cited by this paper
• Occupational asthma due to formaldehyde.

  2001cited by this paper
• The Amygdala : a functional analysis

  2000cited by this paper
• Regulation of adrenocorticotropic hormone secretion: lessons from mice deficient in corticotropin-releasing hormone.

  2000cited by this paper
• Distribution of parvalbumin, calretinin, and calbindin‐D28k immunoreactivity in the rat amygdaloid complex and colocalization with γ‐aminobutyric acid

  2000cited by this paper
• Vanilloid (capsaicin) receptors influence inflammatory sensitivity in response to particulate matter.

  2000cited by this paper
• Immunologic parameters of multiple chemical sensitivity.

  2000cited by this paper
• Central/peripheral nervous system and immune responses.

  2000cited by this paper
• The amygdala - what's happened in the last decade?

  2000cited by this paper
• Neuro‐immune interactions in the lung

  1999cited by this paper
• Olfaction and symptoms in the multiple chemical sensitivities syndrome.

  1999cited by this paper
• A critical analysis of multiple chemical sensitivities.

  1998cited by this paper
• Integrated defense system overlaps as a disease model: with examples for multiple chemical sensitivity.

  1998cited by this paper
• Olfactory cortex

  1998cited by this paper
• Testing the neural sensitization and kindling hypothesis for illness from low levels of environmental chemicals.

  1997cited by this paper
• Role of tachykinin and bradykinin receptors and mast cells in gaseous formaldehydeinduced airway microvascular leakage in rats(ラットのガス化ホルムアルデヒド誘導気道微小血管漏出におけるタキキニン、ブラヂキニン受容体及び肥満細胞の役割)

  1997cited by this paper
• Profile of patients with chemical injury and sensitivity.

  1997cited by this paper
• Rapid down‐regulation of tyrosine hydroxylase expression in the olfactory bulb of naris‐occluded adult rats

  1996cited by this paper
• Formaldehyde exposure enhances inhalative allergic sensitization in the guinea pig

  1996cited by this paper
• Low-level chemical sensitivity: current perspectives

  1996cited by this paper
• Experimental assessment of the sensitizing properties of formaldehyde.

  1996cited by this paper
• Role of tachykinin and bradykinin receptors and mast cells in gaseous formaldehyde-induced airway microvascular leakage in rats.

  1996cited by this paper
• Chemical sensitivity: symptom, syndrome or mechanism for disease?

  1996cited by this paper
• Neurogenic switching: a hypothesis for a mechanism for shifting the site of inflammation in allergy and chemical sensitivity.

  1995cited by this paper
• Behavioral evaluation of the irritant properties of formaldehyde.

  1995cited by this paper
• Irritation and odor as indicators of indoor pollution.

  1995cited by this paper
• Increased IgE antiovalbumin level in mice exposed to formaldehyde.

  1995cited by this paper
• Time-Dependent Sensitization in Animals: A Possible Model of Multiple Chemical Sensitivity in Humans

  1994cited by this paper
• Time-dependent sensitization in animals: a possible model of multiple chemical sensitivity in humans.

  1994cited by this paper
• Olfaction and Multiple Chemical Sensitivity

  1994cited by this paper
• Persistent effects of subchronic toluene exposure on spatial learning and memory, dopamine-mediated locomotor activity and dopamine D2 agonist binding in the rat.

  1993cited by this paper
• Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system.

  1993cited by this paper
• Formaldehyde-induced airway hyperreactivity in vivo and ex vivo in guinea pigs.

  1993cited by this paper
• Multiple Chemical Sensitivity: A Respiratory Disorder?

  1992cited by this paper
• An olfactory-limbic model of multiple chemical sensitivity syndrome: possible relationships to kindling and affective spectrum disorders.

  1992cited by this paper
• Stress, Feedback and Facilitation in the Hypothalamo‐Pituitary‐Adrenal Axis

  1992cited by this paper
• Subacute exposure to low concentrations of toluene affects dopamine-mediated locomotor activity in the rat.

  1991cited by this paper
• Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model

  1991cited by this paper
• Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice.

  1991cited by this paper
• Mechanisms of activation of the sensory irritant receptor by airborne chemicals.

  1991cited by this paper
• Immune activation and autoantibodies in humans with long-term inhalation exposure to formaldehyde.

  1990cited by this paper
• Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat.

  1990cited by this paper
• Clinical and immunologic evaluation of 37 workers exposed to gaseous formaldehyde.

  1990cited by this paper
• Environmental controls and lung disease : report of the ATS workshop on environmental controls and lung disease, Santa Fe, New Mexico, March 24-26, 1988

  1990cited by this paper
• Environmental Controls and Lung Disease.

  1990cited by this paper
• Occupational asthma due to formaldehyde.

  1985cited by this paper
• Transneuronal regulation of tyrosine hydroxylase expression in olfactory bulb of mouse and rat

  1983cited by this paper
• Formaldehyde asthma: challenge exposure levels and fate after five years.

  1982cited by this paper
• Formaldehyde asthma: challenge exposure levels and fate after five years.

  1982cited by this paper
• The synaptic organization of the brain: An introduction

  1974cited by this paper

• Assessment of health risks from exposure to indoor volatile organic compounds in European educational buildings

  2026cites this paper
• Fragrance chemicals in nail salons: Personal inhalation exposures and potential sources

  2024cites this paper
• Species differences in activation of TRPA1 by resin additive-related chemicals relevant to indoor air quality.

  2023cites this paper
• Inhaled Volatile Molecules-Responsive TRP Channels as Non-Olfactory Receptors

  2023cites this paper
• Volatile organic compound concentrations under two different ventilation structures and their health risks in the adhesive tape manufacturing workplace

  2023cites this paper
• Numerical studies of indoor particulate and gaseous micropollutant transport and its impact on human health in densely-occupied spaces.

  2023cites this paper
• Indoor Air Pollution and Decision-Making Behavior: An Interdisciplinary Review

  2022cites this paper
• Air quality in a hospital dental department

  2022cites this paper
• Sex-differences in the effects of indoor air pollutants and household environment on preschool child cognitive development.

  2022cites this paper
• The impact of thermal reprocessing of 3D printable polymers on their mechanical performance and airborne pollutant profiles

  2021cites this paper
• Effects of crude oil vapors on the cardiovascular flow of embryonic Gulf killifish.

  2021cites this paper
• Indoor Formaldehyde Concentration, Personal Formaldehyde Exposure and Clinical Symptoms during Anatomy Dissection Sessions, University of Medicine 1, Yangon

  2021cites this paper
• Indoor Air Quality Monitoring Systems and COVID-19

  2021cites this paper
• Pediatric Asthma Attack and Home Paint Exposure

  2021cites this paper
• Symptomatic Responses to Low‐Level Occupational and Environmental Exposures

  2021cites this paper
• Flexible IoT Gas Sensor Node for Automated Life Science Environments Using Stationary and Mobile Robots

  2021cites this paper
• Organic compound and particle emissions of additive manufacturing with photopolymer resins and chemical outgassing of manufactured resin products

  2021cites this paper
• Housing and Health: Here We Go Again

  2021cites this paper
• Environmental toxicology wars: Organ-on-a-chip for assessing the toxicity of environmental pollutants.

  2020cites this paper
• Performance Analysis of Indoor Smart Environmental Control Factors: Using Temperature to Control the Rate of Formaldehyde Emission

  2019cites this paper
• Occupational exposure to gaseous and particulate contaminants originating from additive manufacturing of liquid, powdered, and filament plastic materials and related post-processes

  2019cites this paper
• Biofiltration of volatile organic compounds using fungi and its conceptual and mathematical modeling.

  2018cites this paper
• Multiple Chemical Sensitivity as A Variant of Idiopathic Intracranial Hypertension: A Case Report

  2018cites this paper
• Lifetime Cancer Risk and Hazard Quotient of BTXs Compounds in Iranian Petrochemical and Petroleum Depot Workers

  2018cites this paper
• A Novel Wireless Wearable Volatile Organic Compound (VOC) Monitoring Device with Disposable Sensors

  2016cites this paper
• The adjuvant effect induced by di-(2-ethylhexyl) phthalate (DEHP) is mediated through oxidative stress in a mouse model of asthma.

  2014cites this paper