Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cellular and Molecular Life Sciences (CMLS)

• Publication date

  2005-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00018-005-4543-3PMID 15868100PMCID PMC11924445
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• BOK and NOXA Are Essential Mediators of p53-dependent Apoptosis*

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  2004cited by this paper
• Structural biology of the Bcl-2 family of proteins.

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• Expression of 11 members of the BCL‐2 family of apoptosis regulatory molecules during human preimplantation embryo development and fragmentation

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• Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

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• Characterization of the signal that directs Bcl-xL, but not Bcl-2, to the mitochondrial outer membrane

  2003cited by this paper
• Induction of cell death by the BH3‐only Bcl‐2 homolog Nbk/Bik is mediated by an entirely Bax‐dependent mitochondrial pathway

  2003cited by this paper
• Helix 6 of tBid is necessary but not sufficient for mitochondrial binding activity

  2003cited by this paper
• p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

  2003cited by this paper
• The Bcl‐2 family pro‐apoptotic molecule, BNIP3 regulates activation‐induced cell death of effector cytotoxic T lymphocytes

  2003cited by this paper
• CD47 and the 19 kDa Interacting Protein-3 (BNIP3) in T Cell Apoptosis*

  2003cited by this paper
• Association of Bax and Bak Homo-oligomers in Mitochondria

  2003cited by this paper
• tBID Homooligomerizes in the Mitochondrial Membrane to Induce Apoptosis*

  2002cited by this paper
• Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.

  2002cited by this paper
• BID regulation by p53 contributes to chemosensitivity

  2002cited by this paper
• Tissue-specific induction of p53 targets in vivo.

  2002cited by this paper
• Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein.

  2002cited by this paper
• The Bcl2 family: regulators of the cellular life-or-death switch

  2002cited by this paper
• Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis

  2001cited by this paper
• Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis

  2001cited by this paper
• Differential Mechanisms of Neuroprotection by 17 β-Estradiol in Apoptotic versus Necrotic Neurodegeneration

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• Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells*

  2001cited by this paper
• Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway.

  2001cited by this paper
• Regulation of p53 localization.

  2001cited by this paper
• Bcl-rambo, a Novel Bcl-2 Homologue That Induces Apoptosis via Its Unique C-terminal Extension*

  2001cited by this paper
• Regulation of p 53 localization

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• Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

  2000cited by this paper
• The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.

  2000cited by this paper
• Cardiolipin provides specificity for targeting of tBid to mitochondria

  2000cited by this paper
• BNIP3 Heterodimerizes with Bcl-2/Bcl-XL and Induces Cell Death Independent of a Bcl-2 Homology 3 (BH3) Domain at Both Mitochondrial and Nonmitochondrial Sites*

  2000cited by this paper
• Evolutionarily conserved Bok proteins in the Bcl‐2 family

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• BNIP3 and Genetic Control of Necrosis-Like Cell Death through the Mitochondrial Permeability Transition Pore

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• Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia.

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• Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.

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  1999cited by this paper
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  1999cited by this paper
• Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL *

  1998cited by this paper
• Diva, a Bcl-2 Homologue that Binds Directly to Apaf-1 and Induces BH3-independent Cell Death*

  1998cited by this paper
• p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.

  1998cited by this paper
• Redistribution of Bax from cytosol to membranes is induced by apoptotic stimuli and is an early step in the apoptotic pathway.

  1998cited by this paper
• Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis

  1997cited by this paper
• Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis.

  1997cited by this paper
• Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members.

  1997cited by this paper
• 17 beta-Estradiol prevents dysfunction of canine coronary endothelium and myocardium and reperfusion arrhythmias after brief ischemia/reperfusion.

  1996cited by this paper
• BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases.

  1996cited by this paper
• Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

  1995cited by this paper
• Chromosome‐9 loss detected by fluorescence in situ hybridization in bladder cancer

  1995cited by this paper
• Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.

  1995cited by this paper

• The endoplasmic reticulum stress - Bcl-2-related ovarian killer (BOK) pathway participates in docosahexaenoic acid-induced adipocyte apoptosis in grass carp (Ctenopharyngodon Idella).

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• The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?

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• Metazoans and Intrinsic Apoptosis: An Evolutionary Analysis of the Bcl-2 Family

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• The Mysteries around the BCL-2 Family Member BOK

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• Regulation of mitochondrial fission by ceramide-induced Bcl-2-related ovarian killer in preeclampsia

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• BOK displays cell death‐independent tumor suppressor activity in non‐small‐cell lung carcinoma

  2017cites this paper
• Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak

  2016cites this paper
• Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak

  2016influential citation
• Molecular profiles and pathogen-induced transcriptional responses of prawn B cell lymphoma-2 related ovarian killer protein (BOK).

  2015cites this paper
• MYB down-regulation enhances sensitivity of U937 myeloid leukemia cells to the histone deacetylase inhibitor LBH589 in vitro and in vivo.

  2014cites this paper
• Hypoxia-inducible regulation of placental BOK expression.

  2014cites this paper
• Regulating cell death at, on, and in membranes.

  2014cites this paper
• Intracellular localization of the BCL-2 family member BOK and functional implications

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• BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice

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• The cloning of hBok, Bcl2-L12 and ADAMTS-16 and the functional research into their regulation in physio logy of the ovary and other reproductive tissues

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