Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2004-04-09

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.BBRC.2004.02.108PMID 15033459
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cloning and functional expression of the mouse homologue of p47phox

  2004cited by this paper
• Akt Phosphorylates p47phox and Mediates Respiratory Burst Activity in Human Neutrophils1

  2003cited by this paper
• Chemoattractant receptor-stimulated F-actin polymerization in the human neutrophil is signaled by 2 distinct pathways.

  2003cited by this paper
• A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase.

  2003cited by this paper
• Extracellular Signal-regulated Kinase 1/2 is Involved in the Activation of NADPH Oxidase Induced by FMLP Receptor but not by Complement Receptor 3 in Rat Neutrophils

  2003cited by this paper
• Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase

  2003cited by this paper
• Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation.

  2002cited by this paper
• Relationship between p38 mitogen-activated protein kinase and small GTPase Rac for the activation of NADPH oxidase in bovine neutrophils.

  2002cited by this paper
• Chemotactic Factor-induced Recruitment and Activation of Tec Family Kinases in Human Neutrophils

  2002cited by this paper
• P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.

  2002cited by this paper
• The neutrophil NADPH oxidase.

  2002cited by this paper
• Protein kinase C isotypes and their specific functions: prologue.

  2002cited by this paper
• Four Tyrosine Residues in Phospholipase C-γ2, Identified as Btk-dependent Phosphorylation Sites, Are Required for B Cell Antigen Receptor-coupled Calcium Signaling*

  2001cited by this paper
• Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis.

  2001cited by this paper
• Regulation of human eosinophil NADPH oxidase activity: A central role for PKCδ

  2001cited by this paper
• Phosphorylation of the leucocyte NADPH oxidase subunit p47(phox) by casein kinase 2: conformation-dependent phosphorylation and modulation of oxidase activity.

  2001cited by this paper
• Protein Kinase C ζ Phosphorylates a Subset of Selective Sites of the NADPH Oxidase Component p47phox and Participates in Formyl Peptide-Mediated Neutrophil Respiratory Burst

  2001cited by this paper
• Ten years of protein kinase B signalling: a hard Akt to follow.

  2001cited by this paper
• Molecular cloning and identification of bottle-nosed dolphin p40(phox), p47(phox) and p67(phox).

  2001cited by this paper
• A motif-based profile scanning approach for genome-wide prediction of signaling pathways

  2001cited by this paper
• ESR detection of intraphagosomal superoxide in polymorphonuclear leukocytes using 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide

  2001cited by this paper
• Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

  2000cited by this paper
• Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction.

  2000cited by this paper
• Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

  2000cited by this paper
• Granulocyte-Macrophage Colony-Stimulating Factor Delays Neutrophil Constitutive Apoptosis Through Phosphoinositide 3-Kinase and Extracellular Signal-Regulated Kinase Pathways1

  2000cited by this paper
• Cloning and expression of bovine p47‐phoxand p67‐phox: comparison with the human and murine homologs

  2000cited by this paper
• Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation

  2000cited by this paper
• Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.

  2000cited by this paper
• Deactivation of neutrophil NADPH oxidase by actin-depolymerizing agents in a cell-free system.

  2000cited by this paper
• 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth.

  2000cited by this paper
• FMLP-induced formation of F-actin in HL60 cells is dependent on PI3-K but not on intracellular Ca2+, PKC, ERK or p38 MAPK

  2000cited by this paper
• Roles of p38 MAPK, PKC and PI3‐K in the signaling pathways of NADPH oxidase activation and phagocytosis in bovine polymorphonuclear leukocytes

  2000cited by this paper
• Phagocytes and oxidative stress.

  2000cited by this paper
• Protein kinase C-beta contributes to NADPH oxidase activation in neutrophils.

  2000cited by this paper
• Phosphoinositide 3-Kinase-dependent and -independent Activation of the Small GTPase Rac2 in Human Neutrophils*

  1999cited by this paper
• NADPH oxidase: an update.

  1999cited by this paper
• Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte-macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production.

  1999cited by this paper
• NADPH oxidase activation and assembly during phagocytosis.

  1999cited by this paper
• Mechanism for Phosphorylation-induced Activation of the Phagocyte NADPH Oxidase Protein p47 phox

  1999cited by this paper
• Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils.

  1999cited by this paper
• Priming of Human Neutrophil Respiratory Burst by Granulocyte/Macrophage Colony-stimulating Factor (GM-CSF) Involves Partial Phosphorylation of p47 phox *

  1999cited by this paper
• Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav.

  1998cited by this paper
• Selective Role for β-Protein Kinase C in Signaling for O⨪2 Generation but Not Degranulation or Adherence in Differentiated HL60 Cells*

  1998cited by this paper
• Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

  1998cited by this paper
• Activation of p47 PHOX , a Cytosolic Subunit of the Leukocyte NADPH Oxidase

  1998cited by this paper
• Activation of phospholipase Cγ by PI 3‐kinase‐induced PH domain‐mediated membrane targeting

  1998cited by this paper
• Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate*

  1998cited by this paper
• Activation of the Leukocyte NADPH Oxidase by Phorbol Ester Requires the Phosphorylation of p47 PHOX on Serine 303 or 304*

  1998cited by this paper
• Bacterial phagocytosis activates extracellular signal‐regulated kinase and p38 mitogen‐activated protein kinase cascades in human neutrophils

  1998cited by this paper
• The leukocyte NADPH oxidase subunit p47PHOX: the role of the cysteine residues.

  1998cited by this paper
• Phosphatidic Acid-mediated Phosphorylation of the NADPH Oxidase Component p47-phox

  1997cited by this paper
• G-Protein-coupled Receptors and Fcγ-receptors Mediate Activation of Akt/Protein Kinase B in Human Phagocytes*

  1997cited by this paper
• Intranuclear translocation of phospholipase C beta2 during HL-60 myeloid differentiation.

  1997cited by this paper
• Phosphorylation of the respiratory burst oxidase subunit p47phox as determined by two-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A, and a mitogen-activated protein kinase.

  1996cited by this paper
• Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK.

  1996cited by this paper
• Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors.

  1995cited by this paper
• Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase.

  1995cited by this paper
• The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

  1994cited by this paper
• Cytosolic [Ca2+] homeostasis and tyrosine phosphorylation of phospholipase C gamma 2 in HL60 granulocytes.

  1993cited by this paper
• Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

  1991cited by this paper

• NADPH Oxidases in Cancer Therapy-Induced Cardiotoxicity: Mechanisms and Therapeutic Approaches

  2025cites this paper
• MAP kinases in regulation of NOX activity stimulated through two types of formyl peptide receptors in murine bone marrow granulocytes.

  2021cites this paper
• Investigation of the effects of indoxyl sulfate, a uremic toxin, on the intracellular oxidation level and phagocytic activity using an HL-60-differentiated human macrophage cell model

  2020cites this paper
• Chronic restraint stress increases angiotensin II potency in the rat carotid: role of cyclooxygenases and reactive oxygen species

  2017cites this paper
• LysoPCs induce Hck‐ and PKCδ‐mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils

  2017cites this paper
• University of Groningen Neutrophil functions in patients with myelodysplasia

  2017cites this paper
• The role of oxidative stress and NADPH oxidase in the pathogenesis of atherosclerosis.

  2017cites this paper
• Regulation of NADPH oxidases in skeletal muscle.

  2016cites this paper
• Anti-TNF certolizumab pegol induces antioxidant response in human monocytes via reverse signaling

  2016cites this paper
• Regulation of Nox enzymes expression in vascular pathophysiology: Focusing on transcription factors and epigenetic mechanisms

  2015cites this paper
• NOX Modifiers—Just a Step Away from Application in the Therapy of Airway Inflammation?

  2015cites this paper
• A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver

  2015cites this paper
• Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides.

  2014cites this paper
• Enhanced Vascular PI3K/Akt-NOX Signaling Underlies the Peripheral NMDAR-mediated Pressor Response in Conscious Rats

  2014cites this paper
• Induction of hepatoma carcinoma cell apoptosis through activation of the JNK-nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-ROS self-driven death signal circuit.

  2014cites this paper
• The Role of Chloride Channels in Regulation of Pulmonary Artery Smooth Muscle Cell Proliferation

  2013cites this paper
• against Klebsiella pneumoniae through the activation of NADPH Leukotrienes enhance the bactericidal activity of alveolar macrophages

  2013cites this paper
• Macrophage phosphoinositide 3-kinase p110delta regulates intestinal homeostasis by directing adaptive immunity and enhancing microbial clearance

  2013influential citation
• Neutrophil Extracellular Traps Microcrystals Induce Formation of Calcium Pyrophosphate Dihydrate Pseudogout-Associated Inflammatory

  2013cites this paper
• Molecular mechanisms of fMLP-induced superoxide generation and degranulation in mouse neutrophils.

  2013cites this paper
• Pseudogout-Associated Inflammatory Calcium Pyrophosphate Dihydrate Microcrystals Induce Formation of Neutrophil Extracellular Traps

  2013cites this paper
• Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2

  2012cites this paper
• Role of Phospholipid Metabolism and G Protein in the Action Induced by Clostridium Perfringens Alpha-Toxin

  2012cites this paper
• Nox enzymes and oxidative stress in atherosclerosis.

  2012cites this paper
• Molecular Mechanisms of N-Formyl-Methionyl-Leucyl-Phenylalanine-Induced Superoxide Generation and Degranulation in Mouse Neutrophils: Phospholipase D Is Dispensable

  2012cites this paper
• Evaluation of pharmacological properties of Danshen compounds by computational and biochemical approaches

  2012cites this paper
• Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS.

  2012cites this paper
• Theophylline in Chronic Obstructive Pulmonary Disease

  2012cites this paper
• Role of Tyrosine Kinase A Receptor (TrkA) on Pathogenicity of Clostridium perfringens Alpha-Toxin

  2012cites this paper
• Interactions of L. monocytogenes with Host Cellular Defenses

  2012cites this paper
• Vascular Biology of Reactive Oxygen Species and NADPH Oxidases: Role in Atherogenesis

  2012cites this paper
• 5-Hydroxy-7-methoxyflavone inhibits N-formyl-L-methionyl-L-leucyl-L-phenylalanine-induced superoxide anion production by specific modulate membrane localization of Tec with a PI3K independent mechanism in human neutrophils.

  2012cites this paper
• Heat-induced inhibition of superoxide dismutase and accumulation of reactive oxygen species leads to HT-22 neuronal cell death

  2011cites this paper
• Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells

  2011cites this paper
• PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fcγ-receptor-stimulated ROS production in neutrophils

  2011cites this paper
• 5‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐3,7‐dimethoxy‐4H‐chromen‐4‐one (MSF‐2) suppresses fMLP‐mediated respiratory burst in human neutrophils by inhibiting phosphatidylinositol 3‐kinase activity

  2011cites this paper
• TLR2 enhances NADPH oxidase activity and killing of Staphylococcus aureus by PMN.

  2011cites this paper
• Theophylline

  2010cites this paper
• Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase

  2010cites this paper
• PKC-delta controls the fMLF-induced overproduction of superoxide by neutrophils.

  2010cites this paper
• The many roles of NOX2 NADPH oxidase-derived ROS in immunity

  2010cites this paper
• Role of Phosphoinositide 3-Kinase &agr;, Protein Kinase C, and L-Type Ca2+ Channels in Mediating the Complex Actions of Angiotensin II on Mouse Cardiac Contractility

  2010cites this paper
• NADPH oxidase-derived reactive oxygen species: involvement in vascular physiology and pathology

  2010cites this paper
• Protective effects of apocynin, an inhibitor of NADPH oxidase activity, in splanchnic artery occlusion and reperfusion

  2010cites this paper
• Chapter 50 – Theophylline

  2009cites this paper
• New potential targets to modulate neutrophil function in inflammation.

  2009cites this paper
• Effect of nitric oxide donors on NADPH oxidase signaling pathway in human neutrophils in vitro.

  2009cites this paper
• Effects of allopurinol on ischemia and reperfusion in rabbit livers.

  2009cites this paper
• NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology

  2009cites this paper
• Effects of Grepafloxacin on the Function of Human Polymorphonuclear Leukocytes and the Phosphorylation of p38 Mitogen-Activated Protein Kinase

  2009cites this paper
• Heat stress and ischemia/reperfusion cause oxidative stress via NADPH oxidase in hypothalamic neurons

  2009cites this paper
• Inhibition of ROS production in peripheral blood mononuclear cells from type 2 diabetic patients by autologous plasma depends on Akt/PKB signaling pathway.

  2008cites this paper
• Potential Adverse Effects of Bronchodilators in the Treatment of Airways Obstruction in Older People

  2008cites this paper
• Protective effects of apocynin and allopurinol on ischemia/reperfusion-induced liver injury in mice.

  2008cites this paper
• Myeloid cell differentiation in response to calcitriol for expression CD11b and CD14 is regulated by myeloid zinc finger‐1 protein downstream of phosphatidylinositol 3‐kinase

  2008cites this paper
• Volume-sensitive NADPH oxidase activity and taurine efflux in NIH3T3 mouse fibroblasts.

  2008cites this paper
• Rac and PI3 Kinase Mediate Endothelial Cell–Reactive Oxygen Species Generation During Normoxic Lung Ischemia

  2008cites this paper
• A possible physiological role of Abeta as a crosslinker

  2008cites this paper
• Monocyte p110α phosphatidylinositol 3‐kinase regulates phagocytosis, the phagocyte oxidase, and cytokine production

  2007cites this paper
• Monocyte p110alpha phosphatidylinositol 3-kinase regulates phagocytosis, the phagocyte oxidase, and cytokine production.

  2007cites this paper
• Age-related impairment of GM-CSF-induced signalling in neutrophils: role of SHP-1 and SOCS proteins.

  2007cites this paper
• Blockade of Class IA Phosphoinositide 3-Kinase in Neutrophils Prevents NADPH Oxidase Activation- and Adhesion-dependent Inflammation*

  2007cites this paper
• Clinical immunology Intracellular calcium ions kinetics and chemiluminescent activity in human neutrophils

  2007cites this paper
• 1α,25‐Dihydroxycholecalciferol activates binding of CREB to a CRE site in the CD14 promoter and drives promoter activity in a phosphatidylinositol‐3 kinase‐dependent manner

  2007cites this paper
• The Effects of Macronutrient Composition on Oxidative Stress and Inflammation in Overweight and Obese Humans

  2007cites this paper
• Insulin generates free radicals in human fibroblasts ex vivo by a protein kinase C-dependent mechanism, which is inhibited by pravastatin.

  2006cites this paper
• Roles of calcium-calmodulin in superoxide production and chemotaxis in FMLP-stimulated rat neutrophils

  2006cites this paper
• Neutrophils from p40phox−/− mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing

  2006cites this paper
• Activation of phosphoinositide 3-kinase and Src family kinase is required for respiratory burst in rat neutrophils stimulated with artocarpol A.

  2006cites this paper
• Pro-atherogenic effect of interleukin-4 in endothelial cells: modulation of oxidative stress, nitric oxide and monocyte chemoattractant protein-1 expression.

  2006cites this paper
• Involvement of protein kinase Cδ in the activation of NADPH oxidase and the phagocytosis of neutrophils

  2006cites this paper
• "Charakterisierung PI3Kγ-assoziierter Proteinkomplexe im Immunsystem"

  2006cites this paper
• Neisseria gonorrhoeae PLD directly interacts with Akt kinase upon infection of primary, human, cervical epithelial cells

  2006cites this paper
• Signal Transduction Mechanism Involved in Clostridium perfringens Alpha-Toxin-Induced Superoxide Anion Generation in Rabbit Neutrophils

  2006cites this paper
• Gram-Negative Bacteria NADPH Oxidase Function and Killing of Cutting Edge : MyD 88 Controls Phagocyte

  2005cites this paper
• Cutting Edge: MyD88 Controls Phagocyte NADPH Oxidase Function and Killing of Gram-Negative Bacteria1

  2005cites this paper
• The Synthetic Chemoattractant Peptide WKYMVm Induces Superoxide Production by Human Eosinophils via the Phosphoinositide 3-Kinase-Mediated Activation of ERK1/2

  2005cites this paper
• A commercial mixture of the brominated flame retardant pentabrominated diphenyl ether (DE-71) induces respiratory burst in human neutrophil granulocytes in vitro.

  2005cites this paper
• The essential role of phosphoinositide 3-kinases (PI3Ks) in regulating pro-inflammatory responses and the progression of cancer.

  2005cites this paper
• Neutrophil functions in patients with myelodysplasia: implications of impaired

  2005cites this paper
• Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase.

  2005cites this paper
• Cutting Edge : MyD 88 Controls Phagocyte NADPH Oxidase Function and Killing of Gram-Negative Bacteria 1

  2005cites this paper
• Pivotal role of NOX‐2‐containing NADPH oxidase in early ischemic preconditioning

  2005cites this paper
• Immunohistochemical study of p47Phox and gp91Phox distributions in rat brain.

  2005cites this paper
• HIV-1 Nef regulates the release of superoxide anions from human macrophages.

  2005cites this paper
• Gram-Negative Bacteria NADPH Oxidase Function and Killing of Cutting Edge: MyD88 Controls Phagocyte

  2005cites this paper
• Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signaling.

  2005cites this paper