Transcriptional regulation of transforming growth factor beta1 by glucose: investigation into the role of the hexosamine biosynthesis pathway.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  American Journal of the Medical Sciences

• Publication date

  2000-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0002-9629(15)40711-6PMID 10746823
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of glycated proteins on the matrix of glomerular epithelial cells.

  1998cited by this paper
• High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells.

  1998cited by this paper
• Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility

  1997cited by this paper
• Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance.

  1996cited by this paper
• Regulation of Glycogen Synthase and Protein Phosphatase-1 by Hexosamines

  1996cited by this paper
• Regulation of Glycogen Synthase by Glucose, Glucosamine, and Glutamine:Fructose-6-Phosphate Amidotransferase

  1995cited by this paper
• Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

  1995cited by this paper
• In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats.

  1995cited by this paper
• Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta.

  1994cited by this paper
• Mechanisms of Glucose-Enhanced Extracellular Matrix Accumulation in Rat Glomerular Mesangial Cells

  1994cited by this paper
• Transforming growth factor-beta and the glomerular extracellular matrix in renal pathology.

  1994cited by this paper
• Renal tubular basement membrane and collagen type IV in diabetes mellitus.

  1993cited by this paper
• Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.

  1993cited by this paper
• The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.

  1993cited by this paper
• Effect of High Glucose on Type IV Collagen Production by Cultured Glomerular Epithelial, Endothelial, and Mesangial Cells

  1993cited by this paper
• Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

  1993cited by this paper
• Regulation of Insulin-Stimulated Glycogen Synthase Activity by Overexpression of Glutamine: Fructose-6-Phosphate Amidotransferase in Rat-1 Fibroblasts

  1993cited by this paper
• Glucose regulation of transforming growth factor-alpha expression is mediated by products of the hexosamine biosynthesis pathway.

  1993cited by this paper
• Carbohydrate regulation of the rat L-type pyruvate kinase gene requires two nuclear factors: LF-A1 and a member of the c-myc family.

  1993cited by this paper
• The pathogenesis of atherosclerosis: a perspective for the 1990s

  1993cited by this paper
• TGF-beta: regulation of extracellular matrix.

  1992cited by this paper
• Transforming growth factor-beta in disease: the dark side of tissue repair.

  1992cited by this paper
• Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells.

  1992cited by this paper
• Elevated glucose stimulates TGF-beta gene expression and bioactivity in proximal tubule.

  1992cited by this paper
• Glucose toxicity.

  1992cited by this paper
• High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta.

  1992cited by this paper
• TGF-β: Regulation of extracellular matrix

  1992cited by this paper
• High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β

  1992cited by this paper
• Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation.

  1991cited by this paper
• Localization of the carbohydrate response element of the rat L-type pyruvate kinase gene.

  1991cited by this paper
• Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.

  1991cited by this paper
• Glucose Toxicity

  1990cited by this paper
• High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells.

  1990cited by this paper
• Characterization of the promoter region of the human transforming growth factor-beta 1 gene.

  1989cited by this paper
• Diabetic Glomerulopathy: Structural Characteristics of the Early and Advanced Stages

  1983cited by this paper

• O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) modification: Emerging pathogenesis and a therapeutic target of diabetic nephropathy

  2024cites this paper
• Renoprotective Effect of Liraglutide Is Mediated via the Inhibition of TGF-Beta 1 in an LLC-PK1 Cell Model of Diabetic Nephropathy

  2022cites this paper
• Molecular Mechanisms Linking Empagliflozin to Renal Protection in the LLC-PK1 Model of Diabetic Nephropathy

  2022cites this paper
• Iron and the Pathophysiology of Diabetes

  2022cites this paper
• TGF-β and Diabetic Nephropathy: Lessons Learned Over the Past 20 Years.

  2020cites this paper
• Upregulation of miRNA-1228-3p alleviates TGF-β-induced fibrosis in renal tubular epithelial cells.

  2020cites this paper
• Subchronic toxicity evaluation of glucosamine and glucosamine in combination with chondroitin sulfate in obese Zucker rats.

  2020cites this paper
• RETRACTED ARTICLE: Diminution of microRNA-98 alleviates renal fibrosis in diabetic nephropathy by elevating Nedd4L and inactivating TGF-β/Smad2/3 pathway

  2020cites this paper
• The American Journal of the Medical Sciences-A Repository of the History of American Medicine.

  2019cites this paper
• Adrenergic stimulation of HK-2 proximal tubular cells in hyperglycaemic conditions

  2018influential citation
• Full Review New developments concerning the proximal tubule in diabetic nephropathy: in vitro models and mechanisms

  2015cites this paper
• New developments concerning the proximal tubule in diabetic nephropathy: in vitro models and mechanisms.

  2015cites this paper
• Regulation Of Stim1 By O-Glcnacylation In Cardiomyocytes

  2013cites this paper
• The research for extracting effective components process of Stigma maydis and Silkworm chrysalis and their hypoglycemic effect

  2011cites this paper
• Oral glucosamine increases expression of transforming growth factor β1 (TGFβ1) and connective tissue growth factor (CTGF) mRNA in rat cartilage and kidney: implications for human efficacy and toxicity.

  2011cites this paper
• Expression profiles of podocytes exposed to high glucose reveal new insights into early diabetic glomerulopathy

  2010cites this paper
• O-GlcNAcylation: a novel post-translational mechanism to alter vascular cellular signaling in health and disease: focus on hypertension.

  2009cites this paper
• Novel Aspects of the Cardiac Renin–Angiotensin System

  2009cites this paper
• Identifizierung neuer E2F-Zielgene in der Wachstumskontrolle und Tumorprogression

  2008cites this paper
• Increased vascular O-GlcNAcylation augments reactivity to constrictor stimuli - VASOACTIVE PEPTIDE SYMPOSIUM.

  2008cites this paper
• Effects of hexosamine biosynthesis on an in vitro model of cardiac ischemia

  2008cites this paper
• Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells

  2007cites this paper
• Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system.

  2007influential citation
• Dietary nitrite inhibits early glomerular injury in streptozotocin-induced diabetic nephropathy in rats.

  2007cites this paper
• Hexosamine induction of oxidative stress, hypertrophy and laminin expression in renal mesangial cells: effect of the anti‐oxidant α‐lipoic acid

  2007cites this paper
• Diabetes-induced alterations in renal medullary microcirculation and metabolism.

  2007cites this paper
• Glucose enhances mesangial cell apoptosis

  2006cites this paper
• An analysis of high glucose and glucosamine-induced gene expression and oxidative stress in renal mesangial cells

  2006cites this paper
• Transforming growth factor-β1 regulation of laminin γ1 and fibronectin expression and survival of mouse mesangial cells

  2005cites this paper
• Transforming growth factor-beta1 regulation of laminin gamma1 and fibronectin expression and survival of mouse mesangial cells.

  2005cites this paper
• Glucosamine induces rapid desensitization of glucose transport in isolated adipocytes by increasing GlcN-6-P levels.

  2005cites this paper
• Hexosamines and TGF-beta1 use similar signaling pathways to mediate matrix protein synthesis in mesangial cells.

  2004cites this paper
• Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.

  2004cites this paper
• Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy.

  2004cites this paper
• Weight loss reduces tissue factor in morbidly obese patients.

  2003cites this paper
• High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells.

  2003cites this paper
• P38 mitogen-activated protein kinase mediates hexosamine-induced TGFβ1 mRNA expression in human mesangial cells

  2003cites this paper
• Overexpression of the Complementary DNA for Human Glutamine:Fructose-6-Phosphate Amidotransferase in Mesangial Cells Enhances Glucose-Induced Fibronectin Synthesis and Transcription Factor Cyclic Adenosine Monophosphate-Responsive Element Binding Phosphorylation

  2003cites this paper
• Insulin Resistance of Glycogen Synthase Mediated byO-Linked N-Acetylglucosamine*

  2003cites this paper
• Role of Hexosamine Biosynthesis in Glucose-mediated Up-regulation of Lipogenic Enzyme mRNA Levels

  2003cites this paper
• P38 mitogen-activated protein kinase mediates hexosamine-induced TGFbeta1 mRNA expression in human mesangial cells.

  2003cites this paper
• GLUT2 is a high affinity glucosamine transporter

  2002cites this paper
• Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway.

  2002cites this paper
• Role of TGF-beta1 in the development of pancreatic fibrosis in Otsuka Long-Evans Tokushima Fatty rats.

  2002cites this paper
• Hypothesis: can glucose-insulin-potassium regimen in combination with polyunsaturated fatty acids suppress lupus and other inflammatory conditions?

  2001cites this paper
• Role of PKC and TGF-beta receptor in glucose-induced proliferation of smooth muscle cells.

  2001cites this paper
• Glucose-induced insulin resistance of phosphatidylinositol 3'-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway.

  2001cites this paper
• Genomic multi-level nutrient-sensing pathways.

  2001cites this paper
• Nutritional regulation of gene expression

  2001cites this paper
• Is there hope for preventing or slowing the progression of chronic renal disease? More support for the role of growth factors.

  2001cites this paper
• Hexosamines as mediators of nutrient sensing: relevance to obesity, insulin resistance, and diabetes

  2001cites this paper
• The role of mesothelial cell biology in peritoneal fibrosis on CAPD

  2001cites this paper
• Hexosamine-induced fibronectin protein synthesis in mesangial cells is associated with increases in cAMP responsive element binding (CREB) phosphorylation and nuclear CREB: the involvement of protein kinases A and C.

  2001cites this paper
• Overexpression of GFAT activates PAI-1 promoter in mesangial cells.

  2000cites this paper
• Regulation of Glutamine: Fructose-6-Phosphate Amidotransferase Activity by High Glucose and Transforming Growth Factor Beta in Rat Mesangial Cells

  2000cites this paper
• Hexosamine regulation of glucose-mediated laminin synthesis in mesangial cells involves protein kinases A and C.

  2000cites this paper
• Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply.

  2000cites this paper