Monocytes in metabolic disorders--opportunities for flow cytometry contributions.

Chronic inflammation has arised as a major underlying cause of atherosclerosis, obesity and diabetes. It is mediated by cells of innate immune system like macrophages but also by their antecedents, circulating monocytes. Roles of monocyte subsets and different markers of monocyte activation in the context of metabolic disorders have been reviewed. Applying cell based approach through flow cytometry in this field has resulted with new understanding of pathophysiologic mechanisms. Possible implications of these insights in diagnosis, prognosis and revealing of therapeutic targets in metabolic disorders remain a challenge for future.

• Publication year

  2010

• Venue

  Collegium Antropologicum

• Publication date

  2010-03-10

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 20432766
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice.

  2009cited by this paper
• CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival.

  2009cited by this paper
• Reactive oxygen species production is increased in the peripheral blood monocytes of obese patients.

  2009cited by this paper
• Risk factor correlates of platelet and leukocyte markers assessed by flow cytometry in a population-based sample.

  2009cited by this paper
• Innate Immunity and Adipocyte Function: Ligand‐specific Activation of Multiple Toll‐like Receptors Modulates Cytokine, Adipokine, and Chemokine Secretion in Adipocytes

  2009cited by this paper
• Reactive oxygen species generation in peripheral blood monocytes and oxidized LDL are increased in hyperlipidemic patients.

  2009cited by this paper
• Leukocyte Activation by Triglyceride-Rich Lipoproteins

  2008cited by this paper
• Atherosclerosis Risk in Communities (ARIC) Carotid MRI flow cytometry study of monocyte and platelet markers: intraindividual variability and reliability.

  2008cited by this paper
• High Glucose Induces Toll-Like Receptor Expression in Human Monocytes

  2008cited by this paper
• CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators.

  2007cited by this paper
• Chemokine Fractalkine Mediates Leukocyte Recruitment to Inflammatory Endothelial Cells in Flowing Whole Blood: A Critical Role for P-Selectin Expressed on Activated Platelets

  2007cited by this paper
• Free radicals and antioxidants in normal physiological functions and human disease.

  2007cited by this paper
• Integrin Expression and H2O2 Production in Circulating and Splenic Leukocytes of Obese Rats

  2007cited by this paper
• Increased expression of Toll like receptor 4 on peripheral‐blood mononuclear cells in patients with coronary arteriosclerosis disease

  2006cited by this paper
• Migratory fate and differentiation of blood monocyte subsets.

  2006cited by this paper
• Multiple roles of Toll-like receptor signaling in atherosclerosis

  2006cited by this paper
• Preventing cardiovascular disease and diabetes: a call to action from the American Diabetes Association and the American Heart Association.

  2006cited by this paper
• Carotid artery intima-media thickness and reactive oxygen species formation by monocytes in hypertensive patients

  2006cited by this paper
• Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

  2006cited by this paper
• Adipose Tissue Metabolism and CD11b Expression on Monocytes in Obese Hypertensives

  2005cited by this paper
• Elevated Concentrations of Nonesterified Fatty Acids Increase Monocyte Expression of CD11b and Adhesion to Endothelial Cells

  2005cited by this paper
• Expansion of Circulating Toll-Like Receptor 4–Positive Monocytes in Patients With Acute Coronary Syndrome

  2005cited by this paper
• Expression of Fractalkine (CX3CL1) and its Receptor, CX3CR1, Is Elevated in Coronary Artery Disease and Is Reduced During Statin Therapy

  2005cited by this paper
• Thematic review series: The Immune System and Atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesis Published, JLR Papers in Press, January 16, 2005. DOI 10.1194/jlr.R400015-JLR200

  2005cited by this paper
• Toll-like receptors: linking innate and adaptive immunity.

  2005cited by this paper
• Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity.

  2005cited by this paper
• Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.

  2004cited by this paper
• Endogenous ligands of Toll‐like receptors

  2004cited by this paper
• TLR Signaling: An Emerging Bridge from Innate Immunity to Atherogenesis1

  2004cited by this paper
• Activation of leukocytes by postprandial lipemia in healthy volunteers.

  2004cited by this paper
• Leptin stimulates the oxidative burst in control monocytes but attenuates the oxidative burst in monocytes from HIV‐infected patients

  2003cited by this paper
• Lipoprotein oxidation and plasma vitamin E in nondiabetic normotensive obese patients.

  2003cited by this paper
• Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans.

  2003cited by this paper
• Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes

  2003cited by this paper
• Adiposity Elevates Plasma MCP-1 Levels Leading to the Increased CD11b-positive Monocytes in Mice*

  2003cited by this paper
• Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis.

  2003cited by this paper
• Prediction of cardiovascular risk using soluble cell adhesion molecules.

  2002cited by this paper
• Oxidative Stress in Leukocytes Is a Possible Link Between Blood Pressure, Blood Glucose, and C-Reacting Protein

  2002cited by this paper
• Monocyte and Neutrophil Adhesion Molecule Expression During Acute Hyperglycemia and After Antioxidant Treatment in Type 2 Diabetes and Control Patients

  2002cited by this paper
• Toll-like receptor 4 polymorphisms and atherogenesis.

  2002cited by this paper
• Effect of Surgically-Induced Weight Loss on Leukocyte Indicators of Chronic Inflammation in Morbid Obesity

  2002cited by this paper
• Expression of Toll-Like Receptors in Human Atherosclerotic Lesions: A Possible Pathway for Plaque Activation

  2002cited by this paper
• Effect of simvastatin on monocyte adhesion molecule expression in patients with hypercholesterolemia.

  2001cited by this paper
• Toll-Like Receptor-4 Is Expressed by Macrophages in Murine and Human Lipid-Rich Atherosclerotic Plaques and Upregulated by Oxidized LDL

  2001cited by this paper
• Human leptin stimulates proliferation and activation of human circulating monocytes.

  1999cited by this paper
• Clinical and angiographic correlates of leukocyte activation in unstable angina.

  1995cited by this paper

• Cell‐ and tissue‐specific epigenetic changes associated with chronic inflammation in insulin resistance and type 2 diabetes mellitus

  2018cites this paper
• Monocytes and macrophages in flow: an ESCCA initiative on advanced analyses of monocyte lineage using flow cytometry

  2017cites this paper
• Bioenergetic analysis of human peripheral blood mononuclear cells

  2015cites this paper
• A Cytofluorometric Study of Membrane Rafts in Human Monocyte Subsets in Atherosclerosis

  2014cites this paper
• Association of monocyte CCR2 expression with obesity and insulin resistance in postmenopausal women.

  2013cites this paper
• Integrating Biomolecular and Clinical Data for Cancer Research: Concepts and Challenges

  2012cites this paper
• Macrophages and Inflammation

  2012cites this paper
• CD14dimCD16+ and CD14+CD16+ Monocytes in Obesity and During Weight Loss: Relationships With Fat Mass and Subclinical Atherosclerosis

  2011cites this paper
• Flow cytometric analysis of glyoxalase‐1 expression in human leukocytes

  2011cites this paper