Structure-Activity Analysis of Flavonoids: Direct and Indirect Antioxidant, and Antiinflammatory Potencies and Toxicities

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Nutrition and Cancer

• Publication date

  2013-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1080/01635581.2013.809127PMID 24087992
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibitory effects of dietary flavonoids on purified hepatic NADH-cytochrome b5 reductase: structure-activity relationships.

  2012influential reference
• When NRF2 Talks, Who's Listening?

  2010cited by this paper
• NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector.

  2010cited by this paper
• Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.

  2009cited by this paper
• Methylation of Dietary Flavones Increases Their Metabolic Stability and Chemopreventive Effects

  2009cited by this paper
• Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles

  2008cited by this paper
• Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line.

  2008cited by this paper
• Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols.

  2008cited by this paper
• Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones.

  2007cited by this paper
• Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants.

  2007influential reference
• Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.

  2007cited by this paper
• Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.

  2006cited by this paper
• Methylated Flavonoids Have Greatly Improved Intestinal Absorption and Metabolic Stability

  2006cited by this paper
• Topoisomerase II inhibition and high yield of endoreduplication induced by the flavonoids luteolin and quercetin.

  2006cited by this paper
• Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cells.

  2006cited by this paper
• Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish.

  2006cited by this paper
• Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel.

  2006cited by this paper
• Pro-oxidant activity of flavonoids induces EpRE-mediated gene expression.

  2006cited by this paper
• The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics

  2005cited by this paper
• Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.

  2005cited by this paper
• Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids.

  2005cited by this paper
• Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1).

  2004cited by this paper
• Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene

  2004cited by this paper
• HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS

  2004cited by this paper
• Absorption and metabolism of flavonoids.

  2004cited by this paper
• Resveratrol inhibits benzo[a]pyrene–DNA adduct formation in human bronchial epithelial cells

  2004cited by this paper
• The "Prochaska" microtiter plate bioassay for inducers of NQO1.

  2004cited by this paper
• A comparative study on the effects of 2,3,7,8,-tetrachlorodibenzo-p-dioxin polychlorinated biphenyl126 and estrogen in human bronchial epithelial cells.

  2004cited by this paper
• Study of the collision-induced radical cleavage of flavonoid glycosides using negative electrospray ionization tandem quadrupole mass spectrometry.

  2003cited by this paper
• Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors.

  2003cited by this paper
• Metabolism of tea flavonoids in the gastrointestinal tract.

  2003cited by this paper
• Antiproliferative activities of citrus flavonoids against six human cancer cell lines.

  2002cited by this paper
• A Brief Account On The Wild Piper (Piperaceae) Of The Crocker Range, Sabah

  2002cited by this paper
• Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): a potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes.

  2002cited by this paper
• Inhibition of cancer growth by resveratrol is related to its low bioavailability.

  2002cited by this paper
• Controls of EGF‐induced morphological transformation of human bronchial epithelial cells

  2001cited by this paper
• Transport and Metabolism of the Tea Flavonoid (–)-Epicatechin by the Human Intestinal Cell Line Caco-2

  2001cited by this paper
• Flavonoid antioxidants.

  2001cited by this paper
• Biological properties of citrus flavonoids pertaining to cancer and inflammation.

  2001cited by this paper
• Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: The indirect antioxidant effects of sulforaphane

  2001cited by this paper
• Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

  2001influential reference
• Lung carcinogenesis: Resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells

  2001cited by this paper
• Composition of flavonoids in fresh herbs and calculation of flavonoid intake by use of herbs in traditional Danish dishes

  2001cited by this paper
• Human airway epithelial cell lines for in vitro drug transport and metabolism studies.

  2000cited by this paper
• Flavonoids as antioxidants.

  2000influential reference
• Intake of Flavonoids and Lung Cancer.

  2000cited by this paper
• Intake of flavonoids and lung cancer.

  2000cited by this paper
• Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes.

  1999cited by this paper
• Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages.

  1998cited by this paper
• On the occurrence of methylated and methoxylated flavonoids in Leptospermum scoparium

  1998cited by this paper
• Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes.

  1997cited by this paper
• Induction of the anticarcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids.

  1997cited by this paper
• Dietary flavonoids and the risk of lung cancer and other malignant neoplasms.

  1997cited by this paper
• Flavonoid intake and coronary mortality in Finland: a cohort study

  1996cited by this paper
• Constituents from the leaves of Virola michelli

  1996cited by this paper
• Human bronchoepithelial cells in vitro as a tool for detection of genotoxic activity of airborne particulates

  1996cited by this paper
• Polyphenols as cancer chemopreventive agents

  1995cited by this paper
• A tetrazolium-based colorimetric MTT assay to quantitate human monocyte mediated cytotoxicity against leukemic cells from cell lines and patients with acute myeloid leukemia.

  1994cited by this paper
• The electrophile counterattack response: protection against neoplasia and toxicity.

  1993cited by this paper
• Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.

  1988cited by this paper
• Sesquiterpene lactones and other constituents of Arnica acaulis

  1988cited by this paper
• Measurement of protein using bicinchoninic acid.

  1985cited by this paper
• Lignoids from the fruit of three Virola species

  1985cited by this paper

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• Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders

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  2023cites this paper
• Natural Products and Biological Activities of Plants from Genus Morus: 2011-2023.

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• Intracellular Redox Behavior of Quercetin and Resveratrol Singly and in Mixtures

  2023cites this paper
• Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants.

  2023cites this paper
• Comprehensive quality evaluation of Compound Bismuth Aluminate Tablets by multiple fingerprint profiles combined with quantitative analysis and antioxidant activity

  2022cites this paper
• Flavonoids as Sirtuin Modulators.

  2022cites this paper
• The Chemistry and the Anti-Inflammatory Activity of Polymethoxyflavonoids from Citrus Genus

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• Construction of an MLR-QSAR Model Based on Dietary Flavonoids and Screening of Natural α-Glucosidase Inhibitors

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• Potential therapeutic use of plant flavonoids in AD and PD

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• Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease

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  2022cites this paper
• Prophylactic Effects of Purple Shoot Green Tea on Cytokine Immunomodulation through Scavenging Free Radicals and NO in LPS-Stimulated Macrophages

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  2022cites this paper
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• The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective.

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