Stimulation of the Labellar Sugar Receptor of the Fleshfly by Mono- and Disaccharides

Responses of the labellar sugar receptor of the fleshfly, Boettcherisca peregrina, were studied over a wide range of concentrations of several sugars (sucrose, maltose, glucose, fructose, and mannose) in single solutions and in mixtures. The results suggest (a) that the receptor sites are not completely differentiated for glucose and for fructose combination, (b) that the receptor site is composed of two subunits. Such suggestions are based on the classical model, where the response is proportional to the number of the sites, two subunits of each site being simultaneously occupied with one molecule of disaccharides or two molecules of monosaccharides. It is shown, however, that an allosteric model gives a somewhat better interpretation of the experimental results.

• Publication year

  1968

• Venue

  The Journal of General Physiology

• Publication date

  1968-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1085/JGP.52.4.559PMID 19873633PMCID 2225817
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stimulation of the Salt Receptor of the Blowfly

  1966cited by this paper
• ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.

  1965cited by this paper
• CHEMICAL STRUCTURE AND STIMULATION BY CARBOHYDRATES

  1963cited by this paper
• Allosteric Effects in Hemoglobin

  1963cited by this paper
• Stimulation of a Primary Taste Receptor by Salts

  1962cited by this paper
• Depression of Taste Sensitivity to Specific Sugars by Their Presence during Development

  1961cited by this paper
• Initiation of spike potentials in contact chemosensory hairs of insects. III. D.C. stimulation and generator potential of labellar chemoreceptor of calliphora.

  1959cited by this paper
• SOME FACTORS CONTROLLING THE INGESTION OF CARBOHYDRATES BY THE BLOWFLY

  1956cited by this paper
• A THEORY OF TASTE STIMULATION

  1954cited by this paper
• A comparison of nutritive values and taste thresholds of carbohydrates for the blowfly.

  1950cited by this paper
• The Determination of Enzyme Dissociation Constants

  1934cited by this paper

• An Electrophysiological Study of the Oral Plate Sensory Organs of the Honey Bee (Apis mellifera L.)

  2021cites this paper
• Dynamics of feeding responses in Pieris brassicae Linn. as a function of chemosensory input : a behavioural, ultrastructural and electrophysiological study

  2012cites this paper
• Multiple pathways from three types of sugar receptor sites to metabotropic transduction pathways of the blowfly: study by the whole cell-clamp experiments.

  2011cites this paper
• Insect odor and taste receptors.

  2006cites this paper
• Trehalose – The Insect ‘Blood’ Sugar

  2003cites this paper
• THE STEREOSPECIFICITY OF THE INOSITOL RECEPTOR OF THE SILKWORM BOMBYX MORI

  2002cites this paper
• An artificial sweetener stimulates the sweet taste in insect: dual effects of glycyrrhizin in Phormia regina.

  2001cites this paper
• Effects of age and blood sugar levels on the proboscis extension of the blow fly Phormia regina.

  2001cites this paper
• Transduction Ion Channels Directly Gated by Sugars on the Insect Taste Cell

  2000cites this paper
• Evolution of gustatory sensitivity in Yponomeuta caterpillars: sensitivity to the stereo-isomers dulcitol and sorbitol is localised in a single sensory cell

  1999cites this paper
• Sugar cell responses to lactose and sucrose in labellar and tarsal taste hairs of Musca domestica

  1998cites this paper
• Ingestion of sugar diets correlates with spike activity in labellar chemosensilla of the flesh‐fly, Neobellieria (= Sarcophaga ) bullata

  1998cites this paper
• Amino acids as taste stimuli for tsetse flies

  1998cites this paper
• Effects of alkali metal cations on the labellar water receptor cell of the fleshfly, Boettcherisca peregrina.

  1997cites this paper
• Quantification of electroantennogram responses of the primary rhinaria ofAcyrthosiphon pisum (Harris) to C4-C8 primary alcohols and aldehydes

  1994cites this paper
• Two types of sugar-binding protein in the labellum of the fly. Putative taste receptor molecules for sweetness

  1993cites this paper
• Chemosensory physiology in an age of transition.

  1990cites this paper
• The labellar sugar receptor ofDrosophila

  1989influential citation
• The chemistry and biochemistry of the sweetness of sugars.

  1987cites this paper
• Destruction and reorganization of the receptor membrane in labellar chemosensory cells of the blowfly. Recovery of responses to sugar after destruction

  1986cites this paper
• Irreversible inhibition of the labellar sugar receptor of the blowfly, Phormia regina, by periodate-activated starch

  1985cites this paper
• Impulse frequency and action potential amplitude in labellar chemosensory neurones of Drosophila melanogaster

  1984cites this paper
• Competition of polysaccharides with sugars for the pyranose and the furanose sites in the labellar sugar receptor cell of the blowfly, Phormia regina

  1983cites this paper
• Discrepancy between the affinities of certain inhibitors for the membrane-bound α-glucosidases and those for the sugar receptor of flies

  1982cites this paper
• Reaction spectra of sugar receptors in different taste hairs of the fly

  1982cites this paper
• 8 – Biochemical Aspects of Sugar Reception in Insects

  1981cites this paper
• 7 – Comparative Study of Sweet Taste Specificity

  1981cites this paper
• Co-operative response of chemically excitable membrane. III. Three-state model.

  1980cites this paper
• Differences in feeding response to sugars between adults and larvae in Drosophila melanogaster.

  1980cites this paper
• Cooperative response of chemically excitable membrane. II. Two-state models and their limitations.

  1980cites this paper
• Physiology of the maxillary sugar sensitive cell in the red turnip beetle,Entomoscelis americana

  1979cites this paper
• The Design of Synthetic Sweeteners

  1979cites this paper
• Co-operative response of chemically excitable membrane. I. Formulation: unified theory of co-operativity.

  1978cites this paper
• The stimulating effect of fatty acids and amino acid derivatives on the labellar sugar receptor of the fleshfly

  1978cites this paper
• Chapter 2 – BIOPHYSICS AND CHEMISTRY OF TASTE

  1978cites this paper
• The specific receptor site for aliphatic carboxylate anion in the labellar sugar receptor of the fleshfly

  1978cites this paper
• Properties of membrane-bound alpha-glucosidases: possible sugar receptor protein of the blowfly, Phormia regina.

  1977cites this paper
• SENSORY AFFECT AND MOTIVATION *

  1977cites this paper
• Stereospecificity for oligosaccharides of two receptor sites in a labellar sugar receptor of the fleshfly.

  1976cites this paper
• Gustatory hairs on the mosquito, Culiseta inornata.

  1976cites this paper
• Electrophysiological responses of galeal contact chemoreceptors of Apis mellifera to selected sugars and electroylytes.

  1976cites this paper
• The peripheral inhibition of the tarsal sugar receptor by sodium chloride in the proboscis extension response of the blowfly,Phormia regina M.

  1976cites this paper
• Stimulation of the gerbil's gustatory receptors by monosaccharides.

  1976cites this paper
• The dynamics of learning in the honey bee (Apis mellifica carnica)

  1975cites this paper
• Chromatographic isolation of α-glucosidases from the taste hair rich tarsi of the flyProtophormia terraenovae. Their possible role as sugar receptor proteins

  1975cites this paper
• Separation of two receptor sites in a single labellar sugar receptor of the flesh-fly by treatment with p-chloromercuribenzoate.

  1974cites this paper
• Autosomal recessive mutation in sugar response of Drosophila

  1974cites this paper
• α-Glucosidases as Sugar Receptor Proteins in Flies

  1974cites this paper
• BEHAVIORAL AND ELECTRICAL RESPONSES TO SUGARS IN DROSOPHILA MELANOGASTER

  1974cites this paper
• Behavioral Responses of Phormia regina (Meigen) to Labellar Stimulation with Amino Acids

  1973cites this paper
• Electrophysiological studies of gustation in lepidopterous larvae

  1973cites this paper
• Isozymes of -glucosidase in the proboscis and legs of flies.

  1972cites this paper
• Stimulation of labellar sugar receptor of the fleshfly by glucosides

  1972cites this paper
• Orientation distribution of globular protein molecules in a two-dimensional lattice: computer simulation.

  1972cites this paper
• The Effects of Temperature on the Labellar Chemoreceptors of the Blowfly

  1972cites this paper
• Electrophysiological studies of gustation in lepidopterous larvae

  1971cites this paper
• Zur Reizwirksamkeit von Monosacchariden bei der Fliege Phormia terraenovae

  1971cites this paper
• Sugar receptor specificity in the fleshfly, Sarcophaga bullata.

  1971cites this paper
• SUGAR RECEPTOR SPECIFICITY IN THE FLESHFLY, SARCOPHAGA

  1971cites this paper
• Riechen in Wasser und in Luft bei Dytiscus marginalis L.

  1971cites this paper
• Molekulare Grundlagen der chemischen Sinne bei Insekten

  1971cites this paper
• The stereospecificity of the inositol receptor of the silkworm Bombyx mori.

  1971cites this paper
• Responses of Olfactory and Gustatory Receptor Cells in Insects

  1970cites this paper
• Molecular structure and conformation in taste perception

  1970cites this paper
• The Effects of Amino Acids on the Labellar Hair Chemosensory Cells of the Fly

  1970cites this paper
• Feeding Behavior of the Blowfly

  1969cites this paper
• The Effects of pH on the Labellar Sugar Receptor of the Fleshfly

  1969cites this paper