Synthesis and Characterization of Novel Acyl-Glycine Inhibitors of GlyT2.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  ACS Chemical Neuroscience

• Publication date

  2017-06-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acschemneuro.7b00105PMID 28574249
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations

  2016cited by this paper
• Glycine transporter2 inhibitors: Getting the balance right.

  2016cited by this paper
• The pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor

  2016cited by this paper
• Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain

  2016cited by this paper
• Crystal Structure of the Human Cannabinoid Receptor CB1.

  2016cited by this paper
• A sliding selectivity scale for lipid binding to membrane proteins.

  2016cited by this paper
• Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.

  2015cited by this paper
• Putative binding sites for arachidonic acid on the human cardiac Kv1.5 channel

  2015cited by this paper
• Phosphatidic acid modulation of Kv channel voltage sensor function

  2014cited by this paper
• Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain

  2013cited by this paper
• X-ray structure of dopamine transporter elucidates antidepressant mechanism

  2013cited by this paper
• Oleoyl‐l‐carnitine inhibits glycine transport by GlyT2

  2013cited by this paper
• Structural evidence for functional lipid interactions in the betaine transporter BetP

  2013cited by this paper
• Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β2 subunit of GABAA receptors?

  2013cited by this paper
• Antiproliferative and antimigratory actions of synthetic long chain n-3 monounsaturated fatty acids in breast cancer cells that overexpress cyclooxygenase-2.

  2012cited by this paper
• N‐arachidonyl‐glycine modulates synaptic transmission in superficial dorsal horn

  2010cited by this paper
• Facile and Stereoselective Synthesis of (Z)-15-Octadecenoic Acid and (Z)-16-Nonadecenoic Acid: Monounsaturated Omega-3 Fatty Acids

  2010cited by this paper
• A Lipid Pathway for Ligand Binding Is Necessary for a Cannabinoid G Protein-coupled Receptor*

  2010cited by this paper
• The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways

  2009cited by this paper
• Extracellular Loops 2 and 4 of GLYT2 Are Required for N-Arachidonylglycine Inhibition of Glycine Transport*

  2009cited by this paper
• Spinal Antiallodynia Action of Glycine Transporter Inhibitors in Neuropathic Pain Models in Mice

  2008cited by this paper
• Membrane lipids: where they are and how they behave

  2008cited by this paper
• Actions of N-arachidonyl-glycine in a rat neuropathic pain model.

  2008cited by this paper
• Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation.

  2008cited by this paper
• Actions of N-arachidonyl-glycine in a rat inflammatory pain model

  2007cited by this paper
• Molecular Basis for Substrate Discrimination by Glycine Transporters*

  2007cited by this paper
• N‐Arachidonyl‐glycine inhibits the glycine transporter, GLYT2a

  2006cited by this paper
• Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice

  2005cited by this paper
• Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality.

  2003cited by this paper
• Effects of oleic acid and its congeners, elaidic and stearic acids, on the structural properties of phosphatidylethanolamine membranes Published, JLR Papers in Press, December 16, 2002. DOI 10.1194/jlr.M200356-JLR200

  2003cited by this paper
• Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2.

  2002cited by this paper
• Identification of a New Class of Molecules, the Arachidonyl Amino Acids, and Characterization of One Member That Inhibits Pain*

  2001cited by this paper
• Neuronal and glial glycine transporters have different stoichiometries.

  2000cited by this paper
• Structural requirements for arachidonylethanolamide interaction with CB1 and CB2 cannabinoid receptors: pharmacology of the carbonyl and ethanolamide groups.

  1998cited by this paper
• Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions.

  1998cited by this paper
• Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability.

  1998cited by this paper
• Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor.

  1997cited by this paper
• Structure-activity analysis of anandamide analogs: relationship to a cannabinoid pharmacophore.

  1996cited by this paper
• Glycine transporters are differentially expressed among CNS cells

  1995cited by this paper
• Role of carnitine and carnitine palmitoyltransferase as integral components of the pathway for membrane phospholipid fatty acid turnover in intact human erythrocytes.

  1992cited by this paper

• “Sowing in Science Brings a Rich Harvest for the People.” Life and Work of S. A. Fokin

  2024cites this paper
• Synthesis and Structure-Activity Relationship Studies of C(13)-Desmethylene-(-)-Zampanolide Analogs.

  2023cites this paper
• The life and activities of S.A. Fokin

  2023cites this paper
• Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2.

  2023cites this paper
• Positive Allosteric Modulators of Glycine Receptors and Their Potential Use in Pain Therapies

  2022cites this paper
• Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2

  2022cites this paper
• Analysis of Binding Determinants for Different Classes of Competitive and Noncompetitive Inhibitors of Glycine Transporters

  2022cites this paper
• Inhibition of Glycine Re-Uptake: A Potential Approach for Treating Pain by Augmenting Glycine-Mediated Spinal Neurotransmission and Blunting Central Nociceptive Signaling

  2021influential citation
• Investigating the lipid fingerprint of SLC6 neurotransmitter transporters: a comparison of dDAT, hDAT, hSERT, and GlyT2.

  2021cites this paper
• The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavity

  2021cites this paper
• Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model

  2021cites this paper
• Lipid fingerprints are similar between SLC6 transporters in the neuronal membrane

  2021cites this paper
• Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle

  2021cites this paper
• Glycine Transporter 2: Mechanism and Allosteric Modulation

  2021cites this paper
• A System for Assessing Dual Action Modulators of Glycine Transporters and Glycine Receptors

  2020influential citation
• Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy

  2020cites this paper
• Identification of N-acyl amino acids that are positive allosteric modulators of glycine receptors.

  2020cites this paper
• MS Binding Assays for Glycine Transporter 2 (GlyT2) Employing Org25543 as Reporter Ligand

  2020cites this paper
• The inhibitory activity of GlyT2 targeting bioactive lipid analgesics are influenced by formation of a deep lipid cavity

  2020cites this paper
• Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain.

  2019cites this paper
• Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics

  2019cites this paper
• Is protein structure enough? A review of the role of lipids in SLC6 transporter function.

  2019cites this paper
• Bioenzymatic and Chemical Derivatization of Renewable Fatty Acids

  2019cites this paper
• Glycine transporter inhibitors: a new avenue for managing neuropathic pain.

  2019cites this paper
• Carbon Chain Length Modulates MDA‐MB‐231 Breast Cancer Cell Killing Mechanisms by Mitochondrially Targeted Aryl−Urea Fatty Acids

  2019cites this paper
• Activity of novel lipid glycine transporter inhibitors on synaptic signalling in the dorsal horn of the spinal cord

  2018cites this paper
• Dual-Targeted Supramolecular Vesicles Based on the Complex of Galactose Capped Pillar[5]Arene and Triphenylphosphonium Derivative for Drug Delivery

  2018cites this paper
• Lipid-Based Inhibitors Act Directly on GlyT2.

  2018cites this paper
• The GlyT1 Inhibitor Bitopertin Ameliorates Allodynia and Hyperalgesia in Animal Models of Neuropathic and Inflammatory Pain

  2018cites this paper
• N-FATTY ACYLGLYCINES: UNDERAPPRECIATED ENDOCANNABINOID-LIKE FATTY ACID AMIDES?

  2017cites this paper